Peter Charlton - Publications, H-index & Citations

Peter Charlton

vertex pharmaceuticals

37H指数

124论文数

5.7K被引数

收录论文 24

发表时间

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (vol 14, pg 298, 2016)

CELL REPORTS

IF6.9

2016-12-01

OAAI

Sanjiv, Kumar; Hagenkort, Anna; Calderon-Montano, Jose Manuel; Koolmeister, Tobias; Reaper, Philip M.; Mortusewicz, Oliver; Jacques, Sylvain A.; Kuiper, Raoul V.; Schultz, Niklas; Scobie, Martin; Charlton, Peter A.; Pollard, John R.; Berglund, Ulrika Warpman; Altun, Mikael; Helleday, Thomas

A Novel Method for Studying the Pharmacokinetics of [14C]Umeclidinium After Application to the Axilla or Palm of Healthy Male Subjects

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2016-06-15

OAAI

Dumitrescu, T. Pene; Santos, L. L.; Hughes, S. C.; Pereira, A. I.; Young, G. C.; Hussey, E.; Charlton, P.; Baptiste-Brown, S.; Stuart, J. S.; Vincent, V.; van Marle, S. P.; Schmith, V. D.

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

CELL REPORTS

IF6.9

2016-01-01

OAAI

The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells

EUROPEAN JOURNAL OF CANCER

IF7.1

2014-11-01

PREAI

Sanjiv, K.; Hagenkort, A.; Reaper, P. M.; Koolmeister, T.; Mortusewicz, O.; Schultz, N.; Scobie, M.; Berglund, U. W.; Charlton, P. A.; Pollard, J. R.; Helleday, T.

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

CANCER BIOLOGY & THERAPY

IF4.6

2014-10-27

223

OAAI

Prevo, Remko; Fokas, Emmanouil; Reaper, Philip M.; Charlton, Peter A.; Pollard, John R.; McKenna, W. Gillies; Muschel, Ruth J.; Brunner, Thomas B.

Comprehensive preclinical evaluation of VE-822, the first ATR-targeted drug candidate: a novel approach to transforming the efficacy of DNA damaging agents.

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Boucher, Diane; Charlton, Peter; Charrier, Jean-Damien; Furey, Brinley; Gu, Yong; Hall, Amy; Hare, Brian; Li, Howard; Milton, Sean; Murphy, Cheryl; Reaper, Philip; Takemoto, Darin; Udagawa, Taturo; Wang, Yuxin; Wood, Mark; Pollard, John

A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

ONCOGENESIS

IF6.4

2013-03-25

OAAI

Falcon, S. C.; Hudson, C. S.; Huang, Y.; Mortimore, M.; Golec, J. M.; Charlton, P. A.; Weber, P.; Sundaram, H.

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

CELL DEATH & DISEASE

IF9.6

2012-12-06

350

OAAI

Fokas, E.; Prevo, R.; Pollard, J. R.; Reaper, P. M.; Charlton, P. A.; Cornelissen, B.; Vallis, K. A.; Hammond, E. M.; Olcina, M. M.; McKenna, W. Gillies; Muschel, R. J.; Brunner, T. B.

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

BRITISH JOURNAL OF CANCER

IF6.8

2012-06-19

154

OAAI

Pires, I. M.; Olcina, M. M.; Anbalagan, S.; Pollard, J. R.; Reaper, P. M.; Charlton, P. A.; McKenna, W. G.; Hammond, E. M.

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

NATURE CHEMICAL BIOLOGY

IF13.7

2011-04-13

588

PREAI

Reaper, Philip M.; Griffiths, Matthew R.; Long, Joanna M.; Charrier, Jean-Damien; MacCormick, Somhairle; Charlton, Peter A.; Golec, Julian M. C.; Pollard, John R.

A role for CXCR4 signalling in the regulation of normal and malignant breast stem cell activity

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Ablett, Matthew; Kojima, Yasushi; Charlton, Peter; Orimo, Akira; Clarke, Robert

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis 泛半胱天冬酶抑制对已建立的脂肪变性和非酒精性脂肪性肝炎动物模型的影响

JOURNAL OF HEPATOLOGY

IF33

2010-09-01

138

PREAI

Anstee, Quentin M.; Concas, Danilo; Kudo, Hiromi; Levene, Adam; Pollard, John; Charlton, Peter; Thomas, Howard C.; Thursz, Mark R.; Goldin, Robert D.

Pan-Caspase Inhibitor VX-166 Reduces Fibrosis in an Animal Model of Nonalcoholic Steatohepatitis

HEPATOLOGY

IF15.8

2009-11-01

213

PREAI

Witek, Rafal P.; Stone, W. Carl; Karaca, F. Gamze; Syn, Wing-Kin; Pereira, Thiago A.; Agboola, Kolade M.; Omenetti, Alessia; Jung, Youngmi; Teaberry, Vanessa; Choi, Steve S.; Guy, Cynthia D.; Pollard, John; Charlton, Peter; Diehl, Anna Mae

VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

CRITICAL CARE

IF9.3

2009-09-09

OAAI

Weber, Peter; Wang, Ping; Maddens, Stephane; Wang, Paul S. H.; Wu, Rongqian; Miksa, Michael; Dong, Weifeng; Mortimore, Michael; Golec, Julian M. C.; Charlton, Peter

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-01-29

269

OAAI

Martin, C; Berridge, G; Mistry, P; Higgins, C; Charlton, P; Callaghan, R

Structural basis for potent inhibition of the Aurora kinases and a T3151 multi-drug resistant mutant form of Abl kinase by VX-680

CANCER LETTERS

IF10.1

2007-06-01

104

PREAI

Cheetham, G. M. T.; Charlton, P. A.; Golec, J. M. C.; Pollard, J. R.

Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-02-07

PREAI

Wang, SM; Wan, NC; Harrison, J; Miller, W; Chuckowree, I; Sohal, S; Hancox, TC; Baker, S; Folkes, A; Wilson, F; Thompson, D; Cocks, S; Farmer, H; Boyce, A; Freathy, C; Broadbridge, J; Scott, J; Depledge, P; Faint, R; Mistry, P; Charlton, P

Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1

BIOCHEMICAL JOURNAL

IF4.3

2003-08-01

OAAI

Einholm, AP; Pedersen, KE; Wind, T; Kulig, P; Overgaard, MT; Jensen, JK; Bodker, JS; Christensen, A; Charlton, P; Andreasen, PA

Dicationic bis(9-methylphenazine-1-carboxamides): Relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2001-03-28

PREAI

Gamage, SA; Spicer, JA; Finlay, GJ; Stewart, AJ; Charlton, P; Baguley, BC; Denny, WA