未登录Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease
Tong, X.; Arasappan, A.; Bennett, F.; Chase, R.; Feld, B.; Guo, Z.; Hart, A.; Madison, V.; Malcolm, B.; Pichardo, J.; Prongay, A.; Ralston, R.; Skelton, A.; Xia, E.; Zhang, R.; Njoroge, F. G. .png)
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收藏Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease InhibitorArasappan, Ashok; Bennett, Frank; Bogen, Stephane L.; Venkatraman, Srikanth; Blackman, Melissa; Chen, Kevin X.; Hendrata, Siska; Huang, Yuhua; Huelgas, Regina M.; Nair, Latha; Padilla, Angela I.; Pan, Weidong; Pike, Russell; Pinto, Patrick; Ruan, Sumei; Sannigrahi, Mousumi; Velazquez, Francisco; Vibulbhan, Bancha; Wu, Wanli; Yang, Weiying; Saksena, Anil K.; Girijavallabhan, Viyyoor; Shih, Neng-Yang; Kong, Jianshe; Meng, Tao; Jin, Yan; Wong, Jesse; McNamara, Paul; Prongay, Andrew; Madison, Vincent; Piwinski, John J.; Cheng, Kuo-Chi; Morrison, Richard; Malcolm, Bruce; Tong, Xiao; Ralston, Robert; Njoroge, F. George 分享 收藏 PRECLINICAL CHARACTERIZATION OF SCH 900518, A NOVEL MECHANISM-BASED INHIBITOR OF HCV NS3 PROTEASETong, X.; Arasappan, A.; Bennett, F.; Chase, R.; Feld, B.; Guo, Z.; Hart, A.; Madison, V.; Malcolm, B.; Pichardo, J.; Prongay, A.; Ralston, R.; Skelton, A.; Xia, E.; Njoroge, F. G. 分享 收藏 Discovery of the HCVNS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II.: Key steps in structure-based optimizationProngay, Andrew J.; Guo, Zhuyan; Yao, Nanhua; Pichardo, John; Fischmann, Thierry; Strickland, Corey; Myers, Joseph, Jr.; Weber, Patricia C.; Beyer, Brian M.; Ingram, Richard; Hong, Zhi; Prosise, Winifred W.; Ramanathan, Lata; Taremi, S. Shane; Yarosh-Tomaine, Taisa; Zhang, Rumin; Senior, Mary; Yang, Rong-Sheng; Malcolm, Bruce; Arasappan, Ashok; Bennett, Frank; Bogen, Stephane L.; Chen, Kevin; Jao, Edwin; Liu, Yi-Tsung; Lovey, Raymond G.; Saksena, Anil K.; Venkatraman, Srikanth; Girijavallabhan, Viyyoor; Njoroge, F. George; Madison, Vincent 分享 收藏 Discovery of (1R, 5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:: A potential therapeutic agent for the treatment of hepatitis C infectionVenkatraman, Srikanth; Bogen, Stephane L.; Arasappan, Ashok; Bennett, Frank; Chen, Kevin; Jao, Edwin; Liu, Yi-Tsung; Lovey, Raymond; Hendrata, Siska; Huang, Yuhua; Pan, Weidong; Parekh, Tejal; Pinto, Patrick; Popov, Veljko; Pike, Russel; Ruan, Sumei; Santhanam, Bama; Vibulbhan, Bancha; Wu, Wanli; Yang, Weiying; Kong, Jianshe; Liang, Xiang; Wong, Jesse; Liu, Rong; Butkiewicz, Nancy; Chase, Robert; Hart, Andrea; Agrawal, Sony; Ingravallo, Paul; Pichardo, John; Kong, Rong; Baroudy, Bahige; Malcolm, Bruce; Guo, Zhuyan; Prongay, Andrew; Madison, Vincent; Broske, Lisa; Cui, Xiaoming; Cheng, Kuo-Chi; Hsieh, Yunsheng; Brisson, Jean-Marc; Prelusky, Danial; Korfmacher, Walter; White, Ronald; Bogdanowich-Knipp, Susan; Pavlovsky, Anastasia; Bradley, Prudence; Saksena, Anil K.; Ganguly, Ashit; Piwinski, John; Girijavallabhan, Viyyoor; Njoroge, F. George 分享 收藏 SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cellsMalcolm, BA; Liu, R; Lahser, F; Agrawal, S; Belanger, B; Butkiewicz, N; Chase, R; Gheyas, F; Hart, A; Hesk, D; Ingravallo, P; Jiang, C; Kong, R; Lu, J; Pichardo, J; Prongay, A; Skelton, A; Tong, X; Venkatraman, S; Xia, E; Girijavallabhan, V; Njoroge, FG 分享 收藏 Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor - Reduced rna replication fitness and partial rescue by second-site mutationsYi, MK; Tong, X; Skelton, A; Chase, R; Chen, T; Prongay, A; Bogen, SL; Saksena, AK; Njoroge, FG; Veselenak, RL; Pyles, RB; Bourne, N; Malcolm, BA; Lemon, SM 分享 收藏 分享 收藏 Binding affinities and geometries of various metal ligands in peptide deformylase inhibitorsMadison, V; Duca, J; Bennett, F; Bohanon, S; Cooper, A; Chu, M; Desai, J; Girijavallabhan, V; Hare, R; Hruza, A; Hendrata, S; Huang, Y; Kravec, C; Malcolm, B; McCormick, J; Miesel, L; Ramanathan, L; Reichert, R; Saksena, A; Wang, J; Weber, PC; Zhu, H; Fischmann, T 分享 收藏 分享 收藏 分享 收藏 分享 收藏 In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketoneMorris, TS; Frormann, S; Shechosky, S; Lowe, C; Lall, MS; GaussMuller, V; Purcell, RH; Emerson, SU; Vederas, JC; Malcolm, BA 分享 收藏 分享 收藏 
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