John C. Vederas - Publications, H-index & Citations

John C. Vederas

university of alberta

76H指数

524论文数

2.4W被引数

收录论文 179

发表时间

Synthesis of β-Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25 β-巯基化氨基酸的合成：朝向套索肽Microcin J25的全化学合成研究

ChemBioChem

IF2.8

2026-09-20

OAAI

Yu-Ting Hsiao; Bethan L. Heard; Ilia Perov; Marco J. van Belkum; Sorina Chiorean; Kaitlyn Towle; Isaac Antwi; John C. Vederas

2-Substituted oxazolyl and thiazolyl amino acids are suitable P1 surrogates for new SARS-CoV-2 main protease inhibitors 2-取代的噁唑基和噻唑基氨基酸是新型SARS-CoV-2主蛋白酶抑制剂的适宜P1替代基

org. biomol. chem.

IF0

2026-06-03

OAAI

Zijie Liu; Tayla J. Van Oers; Conrad Fischer; Anna Nguyen; Johnson Chew; John C. Vederas

Screening apelin analogues and a small molecule agonist as effective cardiovascular therapeutics against reperfusion injury 筛选阿皮林类似物和小分子激动剂作为防治再灌注损伤的有效心血管治疗药物

RSC Med. Chem.

IF0

2025-12-20

OAAI

Anjalee Wijewardane; Kleinberg X. Fernandez; Anran Zhang; Conrad Fischer; Dineth P. Nagahawatta; Xavier Iturrioz; Charlotte Avet; Bethan L. Heard; Catherine Llorens-Cortes; Gavin Y. Oudit; Michel Bouvier; John C. Vederas

Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design 结构洞察揭示了耐尼马特雷韦的SARS-CoV-2 Mpro L50F/E166A/L167F三重突变体-抑制剂复合物的策略，为下一代冠状病毒抑制剂设计提供了指导。

RSC Med. Chem.

IF3.6

2025-08-16

OAAI

Conrad Fischer; Jimmy Lu; Marco J. van Belkum; Sydney Demmon; Pu Chen; Chaoxiang Wang; Tayla J. Van Oers; Tess Lamer; M. Joanne Lemieux; John C. Vederas

Cofactor-Independent Amino Acid Epimerases with Catalytic Serines Instead of Cysteines 辅因子独立型丝氨酸取代半胱氨酸的氨基酸表异构酶

Journal of Molecular Biology

IF4.5

2025-08-06

OAAI

Tess Lamer; Marco J. van Belkum; Pu Chen; Ilia Perov; Bethan L. Heard; Anjalee Wijewardane; M. Joanne Lemieux; John C. Vederas

SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro

CELL REPORTS

IF6.9

2024-12-01

OAAI

Grin, Peter M.; Baid, Kaushal; de Jesus, Hugo C. R.; Kozarac, Nedim; Bell, Peter A.; Jiang, Steven Z.; Kappelhoff, Reinhild; Butler, Georgina S.; Leborgne, Nathan G. F.; Pan, Christina; Pablos, Isabel; Machado, Yoan; Vederas, John C.; Kim, Hugh; Benarafa, Charaf; Banerjee, Arinjay; Overall, Christopher M.

Discovery, characterization, and structure of a cofactor-independent histidine racemase from the oral pathogen Fusobacterium nucleatum

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-11-01

OAAI

Lamer, Tess; Chen, Pu; Venter, Marie J.; van Belkum, Marco J.; Wijewardane, Anjalee; Wu, Chenggang; Lemieux, M. Joanne; Vederas, John C.

A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV

JACS AU

IF8.7

2024-07-30

OAAI

Chen, Pu; Van Oers, Tayla J.; Arutyunova, Elena; Fischer, Conrad; Wang, Chaoxiang; Lamer, Tess; van Belkum, Marco J.; Young, Howard S.; Vederas, John C.; Lemieux, M. Joanne

Lactococcus lactis mutants resistant to lactococcin A and garvicin Q reveal missense mutations in the sugar transport domain of the mannose phosphotransferase system

MICROBIOLOGY SPECTRUM

IF3.8

2024-01-11

OAAI

van Belkum, Marco J.; Aleksandrzak-Piekarczyk, Tamara; Lamer, Tess; Vederas, John C.

Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo (vol 14, 5654, 2023)

NATURE COMMUNICATIONS

IF15.7

2023-11-21

OAAI

Wong, Jeffrey Y. K.; Ekanayake, Arunika I.; Kharchenko, Serhii; Kirberger, Steven E.; Qiu, Ryan; Kelich, Payam; Sarkar, Susmita; Li, Jiaqian; Fernandez, Kleinberg X.; Alvizo-Paez, Edgar R.; Miao, Jiayuan; Kalhor-Monfared, Shiva; John, J. Dwyer; Kang, Hongsuk; Choi, Hwanho; Nuss, John M.; Vederas, John C.; Lin, Yu-Shan; Macauley, Matthew S.; Vukovic, Lela; Pomerantz, William C. K.; Derda, Ratmir

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

ACS BIO & MED CHEM AU

IF4.3

2023-11-15

OAAI

Arutyunova, Elena; Belovodskiy, Alexandr; Chen, Pu; Khan, Muhammad Bashir; Joyce, Michael; Saffran, Holly; Lu, Jimmy; Turner, Zoe; Bai, Bing; Lamer, Tess; Young, Howard S.; Vederas, John C.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Nieman, James A.

Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo 与白蛋白结合并在体内表现出延长循环的全氟芳基大环的遗传编码发现

NATURE COMMUNICATIONS

IF15.7

2023-09-13

OAAI

Wong, Jeffrey Y. K.; Ekanayake, Arunika I.; Kharchenko, Serhii; Kirberger, Steven E.; Qiu, Ryan; Kelich, Payam; Sarkar, Susmita; Li, Jianqian; Fernandez, Kleinberg X.; Alvizo-Paez, Edgar R.; Miao, Jiayuan; Kalhor-Monfared, Shiva; John, J. Dwyer; Kang, Hongsuk; Choi, Hwanho; Nuss, John M.; Vederas, John C.; Lin, Yu-Shan; Macauley, Matthew S.; Vukovic, Lela; Pomerantz, William C. K.; Derda, Ratmir

Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir

ORGANIC LETTERS

IF5

2023-07-31

PREAI

Van Oers, Tayla J.; Piercey, Alexia; Belovodskiy, Alexandr; Reiz, Beïla; Donnelly, Bethan L.; Vuong, Wayne; Lemieux, M. Joanne; Nieman, James A.; Auclair, Karine; Vederas, John C.

Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population 球孢白僵菌作为山松甲虫种群生物防治剂的基因组毒力特征

BMC GENOMICS

IF3.7

2023-07-10

OAAI

Li, Janet X.; Fernandez, Kleinberg X.; Ritland, Carol; Jancsik, Sharon; Engelhardt, Daniel B.; Coombe, Lauren; Warren, Rene L.; van Belkum, Marco J.; Carroll, Allan L.; Vederas, John C.; Bohlmann, Joerg; Birol, Inanc

Simplified cloning and isolation of peptides from sandwiched SUMO-peptide-intein fusion proteins

BMC BIOTECHNOLOGY

IF3.4

2023-04-05

OAAI

Lamer, Tess; Vederas, John C.

Beauveria bassiana exhibits strong virulence against Dendroctonus ponderosae in greenhouse and field experiments 在温室和田间试验中，球孢白僵菌对美国黄柏具有很强的毒力

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IF4.3

2023-04-05

PREAI

Fernandez, Kleinberg X.; Pokorny, Stanley; Ishangulyeva, Guncha; Ullah, Aziz; Todorova, Silvia I.; Erbilgin, Nadir; Carroll, Allan L.; Vederas, John C.

SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

ACS CENTRAL SCIENCE

IF10.4

2023-03-21

OAAI

Chen, Sizhu Amelia; Arutyunova, Elena; Lu, Jimmy; Khan, Muhammad Bashir; Rut, Wioletta; Zmudzinski, Mikolaj; Shahbaz, Shima; Iyyathurai, Jegan; Moussa, Eman W.; Turner, Zoe; Bai, Bing; Lamer, Tess; Nieman, James A.; Vederas, John C.; Julien, Olivier; Drag, Marcin; Elahi, Shokrollah; Young, Howard S.; Lemieux, M. Joanne

Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition

FRONTIERS IN CHEMISTRY

IF4.2

2022-02-24

OAAI

Lu, Jimmy; Chen, Sizhu Amelia; Khan, Muhammad Bashir; Brassard, Raelynn; Arutyunova, Elena; Lamer, Tess; Vuong, Wayne; Fischer, Conrad; Young, Howard S.; Vederas, John C.; Lemieux, M. Joanne

Cytochrome P450-Catalyzed Biosynthesis of a Dihydrofuran Neoclerodane in Magic Mint (Salvia divinorum)

ACS CATALYSIS

IF13.1

2021-12-28

OAAI

Kwon, Moonhyuk; Utomo, Joseph C.; Park, Keunwan; Pascoe, Cameron A.; Chiorean, Sorina; Ngo, Iris; Pelot, Kyle A.; Pan, Cheol-Ho; Kim, Seon-Won; Zerbe, Philipp; Vederas, John C.; Ro, Dae-Kyun

Draft genome sequence of Staphylococcus agnetis 4244, a strain with gene clusters encoding distinct post-translationally modified antimicrobial peptides

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE

IF3.2

2021-12-01

OAAI

Francisco, Marcia Silva; Varella Coelho, Marcus Livio; de Souza Duarte, Andreza Freitas; Towle, Kaitlyn M.; Chiorean, Sorina; Almeida, Gabriela Silva; van Belkum, Marco J.; Nes, Ingolf F.; Vederas, John C.; de Freire Bastos, Maria do Carmo

研究方向