未登录 Generation of Leads for γ-Secretase Modulation Mandal, Mihirbaran; Buevich, Alexei; Caldwell, John P.; Hyde, Lynn; Huang, Xianhai; Liu, Xiaoxiang; McKittrick, Brian; Mazzola, Robert D.; Pissarnitski, Dmitri; Palani, Anandan; Zhang, Lili; Parker, Eric; Xiao, Li; Rindgen, Diane; Zhu, Zhaoning 分享 收藏
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety Mandal, Mihirbaran; Mitra, Kaushik; Grotz, Diane; Lin, Xinjie; Palamanda, Jairam; Kumari, Pramila; Buevich, Alexei; Caldwell, John P.; Chen, Xia; Cox, Kathleen; Favreau, Leonard; Hyde, Lynn; Kennedy, Matthew E.; Kuvelkar, Reshma; Liu, Xiaoxian; Mazzola, Robert D.; Parker, Eric; Rindgen, Diane; Sherer, Edward; Wang, Hongwu; Zhu, Zhaoning; Stamford, Andrew W.; Cumming, Jared N. 分享 收藏
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators Zhao, Zhiqiang; Pissarnitski, Dmitri A.; Huang, Xianhai; Palani, Anandan; Zhu, Zhaoning; Greenlee, William J.; Hyde, Lynn A.; Song, Lixin; Terracina, Giuseppe; Zhang, Lili; Parker, Eric M. 分享 收藏
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage Villarreal, Stephanie; Zhao, Fuqiang; Hyde, Lynn A.; Holder, Daniel; Forest, Thomas; Sondey, Marie; Chen, Xia; Sur, Cyrille; Parker, Eric M.; Kennedy, Matthew E. 分享 收藏
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice Hastings, Nicholas B.; Wang, Xiaohai; Song, Lixin; Butts, Brent D.; Grotz, Diane; Hargreaves, Richard; Hess, J. Fred; Hong, Kwok-Lam Karen; Huang, Cathy Ruey-Ruey; Hyde, Lynn; Laverty, Maureen; Lee, Julie; Levitan, Diane; Lu, Sherry X.; Maguire, Maureen; Mahadomrongkul, Veeravan; McEachern, Ernest J.; Ouyang, Xuesong; Rosahl, Thomas W.; Selnick, Harold; Stanton, Michaela; Terracina, Giuseppe; Vocadlo, David J.; Wang, Ganfeng; Duffy, Joseph L.; Parker, Eric M.; Zhang, Lili 分享 收藏
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity Scott, Jack D.; DeMong, Duane E.; Greshock, Thomas J.; Basu, Kallol; Dai, Xing; Harris, Joel; Hruza, Alan; Li, Sarah W.; Lin, Sue-Ing; Liu, Hong; Macala, Megan K.; Hu, Zhiyong; Mei, Hong; Zhang, Honglu; Walsh, Paul; Poirier, Marc; Shi, Zhi-Cai; Xiao, Li; Agnihotri, Gautam; Baptista, Marco A. S.; Columbus, John; Fell, Matthew J.; Hyde, Lynn A.; Kuvelkar, Reshma; Lin, Yinghui; Mirescu, Christian; Morrow, John A.; Yin, Zhizhang; Zhang, Xiaoping; Zhou, Xiaoping; Chang, Ronald K.; Embrey, Mark W.; Sanders, John M.; Tiscia, Heather E.; Drolet, Robert E.; Kern, Jonathan T.; Sur, Sylvie M.; Renger, John J.; Bilodeau, Mark T.; Kennedy, Matthew E.; Parker, Eric M.; Stamford, Andrew W.; Nargund, Ravi; McCauley, John A.; Miller, Michael W. 分享 收藏
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease Scott, Jack D.; Li, Sarah W.; Brunskill, Andrew P. J.; Chen, Xia; Cox, Kathleen; Cumming, Oared N.; Forman, Mark; Gilbert, Eric J.; Hodgson, Robert A.; Hyde, Lynn A.; Jiang, Qin; Iserloh, Ulrich; Kazakevich, Irina; Kuvelkar, Reshma; Mei, Hong; Meredith, John; Misiaszek, Jeffrey; Orth, Peter; Rossiter, Lana M.; Slater, Meagan; Stone, Julie; Strickland, Corey O.; Voigt, Johannes H.; Wang, Ganfeng; Wang, Hongwu; Wu, Yusheng; Greenlee, William J.; Parker, Eric M.; Kennedy, Matthew E.; Stamford, Andrew W. 分享 收藏
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients Kennedy, Matthew E.; Stamford, Andrew W.; Chen, Xia; Cox, Kathleen; Cumming, Jared N.; Dockendorf, Marissa F.; Egan, Michael; Ereshefsky, Larry; Hodgson, Robert A.; Hyde, Lynn A.; Jhee, Stanford; Kleijn, Huub J.; Kuvelkar, Reshma; Li, Wei; Mattson, Britta A.; Mei, Hong; Palcza, John; Scott, Jack D.; Tanen, Michael; Troyer, Matthew D.; Tseng, Jack L.; Stone, Julie A.; Parker, Eric M.; Forman, Mark S. 分享 收藏
Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors 取代的4-吗啉N-芳基磺酰胺作为 γ-分泌酶抑制剂 Zhao, Zhiqiang; Pissarnitski, Dmitri A.; Josien, Hubert B.; Bara, Thomas A.; Clader, John W.; Li, Hongmei; McBriar, Mark D.; Rajagopalan, Murali; Xu, Ruo; Terracina, Giuseppe; Hyde, Lynn; Song, Lixin; Zhang, Lili; Parker, Eric M.; Osterman, Rebecca; Buevich, Alexei V. 分享 收藏
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates Mandal, Mihirbaran; Wu, Yusheng; Misiaszek, Jeffrey; Li, Guoqing; Buevich, Alexei; Caldwell, John P.; Liu, Xiaoxiang; Mazzola, Robert D.; Orth, Peter; Strickland, Corey; Voigt, Johannes; Wang, Hongwu; Zhu, Zhaoning; Chen, Xia; Grzelak, Michael; Hyde, Lynn A.; Kuvelkar, Reshma; Leach, Prescott T.; Terracina, Giuseppe; Zhang, Lili; Zhang, Qi; Michener, Maria S.; Smith, Brad; Cox, Kathleen; Grotz, Diane; Favreau, Leonard; Mitra, Kaushik; Kazakevich, Irina; McKittrick, Brian A.; Greenlee, William; Kennedy, Matthew E.; Parker, Eric M.; Cumming, Jared N.; Stamford, Andrew W. 分享 收藏
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibitions Fell, Matthew J.; Mirescu, Christian; Basu, Kallol; Cheewatrakoolpong, Boonlert; DeMong, Duane E.; Ellis, J. Michael; Hyde, Lynn A.; Lin, Yinghui; Markgraf, Carrie G.; Mei, Hong; Miller, Michael; Poulet, Frederique M.; Scott, Jack D.; Smith, Michelle D.; Yin, Zhizhang; Zhou, Xiaoping; Parker, Eric M.; Kennedy, Matthew E.; Morrow, John A. 分享 收藏
Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors Zhao, Zhiqiang; Pissarnitski, Dmitri A.; Josien, Hubert B.; Wu, Wen-Lian; Xu, Ruo; Li, Hongmei; Clader, John W.; Burnett, Duane A.; Terracina, Giuseppe; Hyde, Lynn; Lee, Julie; Song, Lixin; Zhang, Lili; Parker, Eric M. 分享 收藏
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology tau病理模型rTg4510小鼠中tau翻译后修饰的分析 Song, Lixin; Lu, Sherry X.; Ouyang, Xuesong; Melchor, Jerry; Lee, Julie; Terracina, Giuseppe; Wang, Xiaohai; Hyde, Lynn; Hess, J. Fred; Parker, Eric M.; Zhang, Lili 分享 收藏
Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior Hodgson, Robert A.; Mullins, Deborra; Lu, Sherry X.; Guzzi, Mario; Zhang, Xiaoping; Bleickardt, Carina J.; Scott, Jack D.; Miller, Michael W.; Stamford, Andrew W.; Parker, Eric M.; Varty, Geoffrey B. 分享 收藏
Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice 选择性腺苷A2A受体拮抗剂SCH 412348对MitoPark小鼠帕金森病表型的影响 Smith, Karen M.; Browne, Susan E.; Jayaraman, Srinivasan; Bleickardt, Carina J.; Hodge, Lisa M.; Lis, Edward; Yao, Leon; Rittle, Sunday L.; Innocent, Nathalie; Mullins, Deborra E.; Boykow, George; Reynolds, Ian J.; Hill, David; Parker, Eric M.; Hodgson, Robert A. 分享 收藏
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Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation Mandal, Mihirbaran; Zhu, Zhaoning; Cumming, Jared N.; Liu, Xiaoxiang; Strickland, Corey; Mazzola, Robert D.; Caldwell, John P.; Leach, Prescott; Grzelak, Michael; Hyde, Lynn; Zhang, Qi; Terracina, Giuseppe; Zhang, Lili; Chen, Xia; Kuvelkar, Reshma; Kennedy, Matthew E.; Favreau, Leonard; Cox, Kathleen; Orth, Peter; Buevich, Alexei; Voig, Johannes; Wang, Hongwu; Kazakevich, Irina; McKittrick, Brian A.; Greenlee, William; Parker, Eric M.; Stamford, Andrew W. 分享 收藏
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction Stamford, Andrew W.; Scott, Jack D.; Li, Sarah W.; Babu, Suresh; Tadesse, Dawit; Hunter, Rachael; Wu, Yusheng; Misiaszek, Jeffrey; Cumming, Jared N.; Gilbert, Eric J.; Huang, Chunli; McKittrick, Brian A.; Hong, Liwu; Guo, Tao; Zhu, Zhaoning; Strickland, Corey; Orth, Peter; Voigt, Johannes H.; Kennedy, Matthew E.; Chen, Xia; Kuvelkar, Reshma; Hodgson, Robert; Hyde, Lynn A.; Cox, Kathleen; Favreau, Leonard; Parker, Eric M.; Greenlee, William J. 分享 收藏
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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease 发现SCH 900229，一种有效的早老素1选择性 γ-分泌酶抑制剂，用于治疗阿尔茨海默氏病 Wu, Wen-Lian; Domalski, Martin; Burnett, Duane A.; Josien, Hubert; Bara, Thomas; Rajagopalan, Murali; Xu, Ruo; Clader, John; Greenlee, William J.; Brunskill, Andrew; Hyde, Lynn A.; Del Vecchio, Robert A.; Cohen-Williams, Mary E.; Song, Lixin; Lee, Julie; Terracina, Giuseppe; Zhang, Qi; Nomeir, Amin; Parker, Eric M.; Zhang, Lili 分享 收藏
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