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An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag Short title: Controlled bioconjugation via O-glycan engineering Murray, Thomas, V; Kozakowska-McDonnell, Kasia; Tibbles, Adam; Taylor, Annabel; Higazi, Daniel; Rossy, Emmanuel; Rossi, Alessandra; Genapathy, Sivaneswary; Tamburrino, Giulia; Rath, Nicola; Tigue, Natalie; Lindo, Vivian; Vaughan, Tristan; Papworth, Monika A. 分享 收藏
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Inducing protein aggregation by extensional flow Dobson, John; Kumar, Amit; Willis, Leon F.; Tuma, Roman; Higazi, Daniel R.; Turner, Richard; Lowe, David C.; Ashcroft, Alison E.; Radford, Sheena E.; Kapur, Nikil; Brockwell, David J. 分享 收藏
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues Phillips, Jonathan J.; Buchanan, Andrew; Andrews, John; Chodorge, Matthieu; Sridharan, Sudharsan; Mitchell, Laura; Burmeister, Nicole; Kippen, Alistair D.; Vaughan, Tristan J.; Higazi, Daniel R.; Lowe, David 分享 收藏
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential Tigue, Natalie J.; Bamber, Lisa; Andrews, John; Ireland, Samantha; Hair, James; Carter, Edward; Sridharan, Sudharsan; Jovanovic, Jelena; Rees, D. Gareth; Springall, Jeremy S.; Solier, Emilie; Li, Yi-Ming; Chodorge, Matthieu; Perez-Martinez, David; Higazi, Daniel R.; Oberst, Michael; Kennedy, Maureen; Black, Chelsea M.; Yan, Li; Schwickart, Martin; Maguire, Shaun; Cann, Jennifer A.; de Haan, Lolke; Young, Lesley L.; Vaughan, Tristan; Wilkinson, Robert W.; Stewart, Ross 分享 收藏
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo Dobson, Claire L.; Devine, Paul W. A.; Phillips, Jonathan J.; Higazi, Daniel R.; Lloyd, Christopher; Popovic, Bojana; Arnold, Joanne; Buchanan, Andrew; Lewis, Arthur; Goodman, Joanne; van der Walle, Christopher F.; Thornton, Peter; Vinall, Lisa; Lowne, David; Aagaard, Anna; Olsson, Lise-Lotte; Wollberg, Anna Ridderstad; Welsh, Fraser; Karamanos, Theodoros K.; Pashley, Clare L.; Iadanza, Matthew G.; Ranson, Neil A.; Ashcroft, Alison E.; Kippen, Alistair D.; Vaughan, Tristan J.; Radford, Sheena E.; Lowe, David C. 分享 收藏
The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan Tsui, Ping; Higazi, Daniel R.; Wu, Yanli; Dunmore, Rebecca; Solier, Emilie; Kasali, Toyin; Bond, Nicholas J.; Huntington, Catherine; Carruthers, Alan; Hood, John; Borrok, M. Jack; Barnes, Arnita; Rickert, Keith; Phipps, Sandrina; Shirinian, Lena; Zhu, Jie; Bowen, Michael A.; Dall'Acqua, William; Murray, Lynne A. 分享 收藏
LATE-BREAKING ABSTRACT: Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation Cohen, Suzanne; Scott, Ian; Majithiya, Jayesh; Rapley, Laura; Kemp, Benjamin; Bond, Nicholas; Sims, Dorothy; Brightling, Christopher; Butler, Robin; Higazi, Daniel; Corkill, Dominic; May, Richard; Mustelin, Tomas; Sleeman, Matthew 分享 收藏
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation Cohen, E. Suzanne u; Scott, Ian C.; Majithiya, Jayesh B.; Rapley, Laura; Kemp, Benjamin P.; England, Elizabeth; Rees, D. Gareth; Overed-Sayer, Catherine L.; Woods, Joanne; Bond, Nicholas J.; Veyssier, Christel Seguy; Embrey, Kevin J.; Sims, Dorothy A.; Snaith, Michael R.; Vousden, Katherine A.; Strain, Martin D.; Chan, Denice T. Y.; Carmen, Sara; Huntington, Catherine E.; Flavell, Liz; Xu, Jianqing; Popovic, Bojana; Brightling, Christopher E.; Vaughan, Tristan J.; Butler, Robin; Lowe, David C.; Higazi, Daniel R.; Corkill, Dominic J.; May, Richard D.; Sleeman, Matthew A.; Mustelin, Tomas 分享 收藏
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase Klein, Tobias; Vajpai, Navratna; Phillips, Jonathan J.; Davies, Gareth; Holdgate, Geoffrey A.; Phillips, Chris; Tucker, Julie A.; Norman, Richard A.; Scott, Andrew D.; Higazi, Daniel R.; Lowe, David; Thompson, Gary S.; Breeze, Alexander L. 分享 收藏
Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab Spooner, Jennifer; Keen, Jenny; Nayyar, Kalpana; Birkett, Neil; Bond, Nicholas; Bannister, David; Tigue, Natalie; Higazi, Daniel; Kemp, Benjamin; Vaughan, Tristan; Kippen, Alistair; Buchanan, Andrew 分享 收藏
Endothelin-1-Stimulated InsP3-Induced Ca2+ Release Is a Nexus for Hypertrophic Signaling in Cardiac Myocytes Endothelin-1-Stimulated InsP3-Induced Ca2释放是心肌细胞肥大信号传导的联系 Higazi, Daniel R.; Fearnley, Claire J.; Drawnel, Faye M.; Talasila, Amarnath; Corps, Elaine M.; Ritter, Oliver; McDonald, Fraser; Mikoshiba, Katsuhiko; Bootman, Martin D.; Roderick, H. Llewelyn 分享 收藏
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