Christian Loc’h - Publications, H-index & Citations

Christian Loc’h

Royal Prince Alfred Hospital

39H指数

211论文数

4.6K被引数

收录论文 47

发表时间

Biochemical and cell-based assay platforms for development of RAF inhibitors against human cancers

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Wu, Jianghong; Wan, Yong; Liang, Shuguang; Gallagher, Peter; Liang, Li; Loch, Christian; Ma, Haiching

Screening the entire kinase-directed, FDA-approved pharmacopeia against the largest collection of wild-type and mutant kinases reveals many opportunities for drug repurposing and targeted therapy

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Loch, Christian M.; Liang, Shuguang; Wu, Jianghong; Eason, Mia; Goupil, Alison; Acinapura, Anthony; Purcell, Jamie; Dominguez, Maia

Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions 泛素连接酶CHFR通过泛素化介导的VE-钙粘蛋白降解破坏内皮细胞粘附连接

NATURE COMMUNICATIONS

IF15.7

2023-10-18

OAAI

Tiruppathi, Chinnaswamy; Wang, Dong-Mei; Ansari, Mohammad Owais; Bano, Shabana; Tsukasaki, Yoshikazu; Mukhopadhyay, Amitabha; Joshi, Jagdish C.; Loch, Christian; Niessen, Hans W. M.; Malik, Asrar B.

Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining

NUCLEIC ACIDS RESEARCH

IF13.1

2022-04-14

OAAI

Cabello-Lobato, Maria Jose; Jenner, Matthew; Cisneros-Aguirre, Metztli; Bruninghoff, Kira; Sandy, Zac; da Costa, Isabelle C.; Jowitt, Thomas A.; Loch, Christian M.; Jackson, Stephen P.; Wu, Qian; Mootz, Henning D.; Stark, Jeremy M.; Cliff, Matthew J.; Schmidt, Christine K.

Synthesis and pharmacological evaluation of [18F]PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human single nucleotide polymorphism rs6971

RSC MEDICINAL CHEMISTRY

IF3.6

2021-01-01

OAAI

Mattner, Filomena; Katsifis, Andrew; Bourdier, Thomas; Loc'h, Christian; Berghofer, Paula; Fookes, Christopher; Hung, Tzong-Tyng; Jackson, Timothy; Henderson, David; Pham, Tien; Lee, Brendan J.; Shepherd, Rachael; Greguric, Ivan; Wyatt, Naomi; Le, Thanh; Poon, Jackson; Power, Carl; Fulham, Michael

The newly established bovine endometrial gland cell line (BEGC) forms gland acini in vitro and is only IFNτ- responsive (MAPK42/ 44 activation) after E2 and P4-pre-incubation

PLACENTA

IF2.5

2018-07-01

PREAI

Haeger, Jan-Dirk; Loch, Christian; Pfarrer, Christiane

IFNτ mediates chemotaxis, motility, metabolism and CK18 downregulation in bovine trophoblast cells in vitro via STAT1 and MAPK42/44 signaling

PLACENTA

IF2.5

2018-04-01

PREAI

Loch, C.; Haeger, J. -D.; Pfarrer, C.

Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia

BRITISH JOURNAL OF PSYCHIATRY

IF7.6

2018-01-02

147

OAAI

Xiberas, X; Martinot, JL; Mallet, L; Artiges, E; Loc'h, C; Mazière, B; Paillère-Martinot, ML

INVIVO ASSAY FOR NEUROLEPTIC RECEPTOR-BINDING IN THE STRIATUM - POSITRON TOMOGRAPHY IN HUMANS

BRITISH JOURNAL OF PSYCHIATRY

IF7.6

2018-01-02

PREAI

CAMBON, H; BARON, JC; BOULENGER, JP; LOCH, C; ZARIFIAN, E; MAZIERE, B

CENTRAL D-2 RECEPTORS AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA

BRITISH JOURNAL OF PSYCHIATRY

IF7.6

2018-01-02

PREAI

MARTINOT, JL; PAILLEREMARTINOT, ML; LOCH, C; LECRUBIER, Y; DAOCASTELLANA, MH; AUBIN, F; ALLILAIRE, JF; MAZOYER, B; MAZIERE, B; SYROTA, A

THE ESTIMATED DENSITY OF D2 STRIATAL RECEPTORS IN SCHIZOPHRENIA - A STUDY WITH POSITRON EMISSION TOMOGRAPHY AND BR-76 BROMOLISURIDE

BRITISH JOURNAL OF PSYCHIATRY

IF7.6

2018-01-02

109

PREAI

MARTINOT, JL; PAILLEREMARTINOT, ML; LOCH, C; HARDY, P; POIRIER, MF; MAZOYER, B; BEAUFILS, B; MAZIERE, B; ALLILAIRE, JF; SYROTA, A

BOVINE INTERFERON TAU (IFNτ) INDUCES MOTILITY, METABOLISM AND CHEMOTAXIS OF BOVINE TROPHOBLAST CELLS BY ACTIVATING SEVERAL INTERFERON ASSOCIATED SIGNALLING PATHWAYS AND RECEPTORS

PLACENTA

IF2.5

2017-09-01

PREAI

Loch, Christian; Haeger, Jan-Dirk; Pfarrer, Christiane

ISOLATION OF A PERMANENT BOVINE ENDOMETRIAL GLAND CELL LINE (BEGC) WHICH RETAIN THEIR EPITHELIAL PHENOTYPE IN VITRO

PLACENTA

IF2.5

2017-09-01

PREAI

Haeger, Jan-Dirk; Loch, Christian; Pfarrer, Christiane

Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [18F]PBR102 and [18F]PBR111

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2016-10-04

PREAI

Eberl, S.; Katsifis, A.; Peyronneau, M. A.; Wen, L.; Henderson, D.; Loc'h, C.; Greguric, I.; Verschuer, J.; Pham, T.; Lam, P.; Mattner, F.; Mohamed, A.; Fulham, M. J.

Comparison of in vivo binding properties of the 18-kDa translocator protein (TSPO) ligands [18F]PBR102 and [18F]PBR111 in a model of excitotoxin-induced neuroinflammation

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2014-09-18

PREAI

Callaghan, P. D.; Wimberley, C. A.; Rahardjo, G. L.; Berghofer, P. J.; Pham, T. Q.; Jackson, T.; Zahra, D.; Bourdier, T.; Wyatt, N.; Greguric, I.; Howell, N. R.; Siegele, R.; Pastuovic, Z.; Mattner, F.; Loc'h, C.; Gregoire, M. C.; Katsifis, A.

Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102

NUCLEAR MEDICINE AND BIOLOGY

IF3

2012-07-01

PREAI

Verschuer, Jordan D.; Towson, Jocelyn; Eberl, Stefan; Katsifis, Andrew; Henderson, David; Lam, Peter; Wen, Lingfeng; Loc'h, Christian; Mattner, Filomena; Thomson, Sally; Mohamed, Armin; Fulham, Michael J.

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy

EJNMMI RESEARCH

IF3

2012-01-01

OAAI

Dedeurwaerdere, Stefanie; Callaghan, Paul D.; Pham, Tien; Rahardjo, Gita L.; Amhaoul, Halima; Berghofer, Paula; Quinlivan, Mitchell; Mattner, Filomena; Loc'h, Christian; Katsifis, Andrew; Gregoire, Marie-Claude

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1 泛素化和USP8-dependent去泛素化在质膜KCa3.1的内吞作用和溶酶体靶向中的作用

FASEB JOURNAL

IF4.2

2011-08-09

OAAI

Balut, Corina M.; Loch, Christian M.; Devor, Daniel C.

A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma

NUCLEAR MEDICINE AND BIOLOGY

IF3

2011-01-01

PREAI

Katsifis, Andrew; Loc'h, Christian; Henderson, David; Bourdier, Thomas; Pham, Tien; Greguric, Ivan; Lam, Peter; Callaghan, Paul; Mattner, Filomena; Eberl, Stefan; Fulham, Michael

Use of a Single-Chain Antibody Library for Ovarian Cancer Biomarker Discovery

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2010-07-01

OAAI

Ramirez, Arturo B.; Loch, Christian M.; Zhang, Yuzheng; Liu, Yan; Wang, Xiaohong; Wayner, Elizabeth A.; Sargent, Jonathon E.; Sibani, Sahar; Hainsworth, Eugenie; Mendoza, Eliseo A.; Eugene, Ralph; LaBaer, Joshua; Urban, Nicole D.; McIntosh, Martin W.; Lampe, Paul D.

研究方向