Edward Darżynkiewicz - Publications, H-index & Citations

Edward Darżynkiewicz

University of Warsaw

49H指数

313论文数

8.1K被引数

收录论文 63

发表时间

Hammerhead ribozymes directed against mRNA of an essential gene inhibit Escherichia coli growth and enhance tetracycline efficacy 锤头状核酶靶向作用于必需基因的mRNA，能够抑制大肠杆菌的生长并增强四环素的疗效。

Frontiers in Microbiology

IF4.5

2025-10-03

OAAI

Joanna Miszkiewicz-Golec; Ksenia Maximowa; Maciej Łukaszewicz; Dariusz Bartosik; Edward Darżynkiewicz†; Joanna Trylska

RNA

IF5

2024-07-15

OAAI

Geng, Jingping; Chrabaszczewska, Magdalena; Kurpiejewski, Karol; Stankiewicz-Drogon, Anna; Jankowska-Anyszka, Marzena; Darzynkiewicz, Edward; Grzela, Renata

miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels

SCIENTIFIC REPORTS

IF3.9

2024-02-20

OAAI

Nagaraj, Siranjeevi; Stankiewicz-Drogon, Anna; Darzynkiewicz, Edward; Wojda, Urszula; Grzela, Renata

The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2024-02-06

OAAI

Kurpiejewski, Karol; Stankiewicz-Drogon, Anna; Piecyk, Karolina; Rajkowska, Eliza; Skrzypczyk, Paulina; Geng, Jingping; Darzynkiewicz, Edward; Grzela, Renata; Jankowska-Anyszka, Marzena

Mesenchymal stem cell engineering by ARCA analog-capped mRNA

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-09-01

OAAI

Andrzejewska, Anna; Grzela, Renata; Stankiewicz-Drogon, Anna; Rogujski, Piotr; Nagaraj, Siranjeevi; Darzynkiewicz, Edward; Lukomska, Barbara; Janowski, Miroslaw

The Nematode Eukaryotic Translation Initiation Factor 4E/G Complex Works with a trans-Spliced Leader Stem-Loop To Enable Efficient Translation of Trimethylguanosine-Capped RNAs

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Wallace, Adam; Filbin, Megan E.; Veo, Bethany; McFarland, Craig; Stepinski, Janusz; Jankowska-Anyszka, Marzena; Darzynkiewicz, Edward; Davis, Richard E.

N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering N2修饰的二核苷酸帽类似物是mRNA工程的有效工具

RNA

IF5

2022-11-23

OAAI

Grzela, Renata; Piecyk, Karolina; Stankiewicz-Drogon, Anna; Pietrow, Paulina; Lukaszewicz, Maciej; Kurpiejewski, Karol; Darzynkiewicz, Edward; Jankowska-Anyszka, Marzena

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

NUCLEIC ACIDS RESEARCH

IF13.1

2021-06-14

OAAI

Galloway, Alison; Kaskar, Aneesa; Ditsova, Dimitrinka; Atrih, Abdelmadjid; Yoshikawa, Harunori; Gomez-Moreira, Carolina; Suska, Olga; Warminski, Marcin; Grzela, Renata; Lamond, Angus, I; Darzynkiewicz, Edward; Jemielity, Jacek; Cowling, Victoria H.

Effect of the His-Tag Location on Decapping Scavenger Enzymes and Their Hydrolytic Activity toward Cap Analogs

ACS OMEGA

IF4.3

2020-05-06

OAAI

Ferenc-Mrozek, Aleksandra; Bojarska, Elzbieta; Stepinski, Janusz; Darzynkiewicz, Edward; Lukaszewicz, Maciej

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

RNA

IF5

2019-10-28

OAAI

Miedziak, Beata; Dobiezynska, Anna; Darzynkiewicz, Zbigniew M.; Bartkowska, Julia; Miszkiewicz, Joanna; Kowalska, Joanna; Warminski, Marcin; Tyras, Michal; Trylska, Joanna; Jemielity, Jacek; Darzynkiewicz, Edward; Grzela, Renata

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

CELL CYCLE

IF3.4

2018-08-17

OAAI

Kocmik, Ilona; Piecyk, Karolina; Rudzinska, Magdalena; Niedzwiecka, Anna; Darzynkiewicz, Edward; Grzela, Renata; Jankowska-Anyszka, Marzena

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides

RNA

IF5

2018-02-26

OAAI

Grzela, Renata; Nasilowska, Karolina; Lukaszewicz, Maciej; Tyras, Michal; Stepinski, Janusz; Jankowska-Anyszka, Marzena; Bojarska, Elzbieta; Darzynkiewicz, Edward

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

NUCLEIC ACIDS RESEARCH

IF13.1

2017-06-28

OAAI

Rydzik, Anna M.; Warminski, Marcin; Sikorski, Pawel J.; Baranowski, Marek R.; Walczak, Sylwia; Kowalska, Joanna; Zuberek, Joanna; Lukaszewicz, Maciej; Nowak, Elzbieta; Claridge, Timothy D. W.; Darzynkiewicz, Edward; Nowotny, Marcin; Jemielity, Jacek

Amino-Functionalized 5′ Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA

BIOCONJUGATE CHEMISTRY

IF3.9

2017-06-27

PREAI

Warminski, Marcin; Sikorski, Pawel J.; Warminska, Zofia; Lukaszewicz, Maciej; Kropiwnicka, Anna; Zuberek, Joanna; Darzynkiewicz, Edward; Kowalska, Joanna; Jemielity, Jacek

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

NUCLEIC ACIDS RESEARCH

IF13.1

2016-10-07

OAAI

Strenkowska, Malwina; Grzela, Renata; Majewski, Maciej; Wnek, Katarzyna; Kowalska, Joanna; Lukaszewicz, Maciej; Zuberek, Joanna; Darzynkiewicz, Edward; Kuhn, Andreas N.; Sahin, Ugur; Jemielity, Jacek

Phosphate-modified analogues of m7GTP and m7Gppppm7G-Synthesis and biochemical properties

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-09-01

PREAI

Ziemniak, Marcin; Kowalska, Joanna; Lukaszewicz, Maciej; Zuberek, Joanna; Wnek, Katarzyna; Darzynkiewicz, Edward; Jemielity, Jacek

How to find the optimal partner-studies of snurportin 1 interactions with U snRNA 5′ TMG-cap analogues containing modified 2-amino group of 7-methylguanosine

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-08-01

PREAI

Piecyk, Karolina; Niedzwiecka, Anna; Ferenc-Mrozek, Aleksandra; Lukaszewicz, Maciej; Darzynkiewicz, Edward; Jankowska-Anyszka, Marzena

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

NUCLEIC ACIDS RESEARCH

IF13.1

2014-08-22

OAAI

Kowalska, Joanna; Wypijewska del Nogal, Anna; Darzynkiewicz, Zbigniew M.; Buck, Janina; Nicola, Corina; Kuhn, Andreas N.; Lukaszewicz, Maciej; Zuberek, Joanna; Strenkowska, Malwina; Ziemniak, Marcin; Maciejczyk, Maciej; Bojarska, Elzbieta; Rhoads, Robert E.; Darzynkiewicz, Edward; Sahin, Ugur; Jemielity, Jacek

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors

RNA

IF5

2014-08-22

OAAI

Piecyk, Karolina; Lukaszewicz, Maciej; Darzynkiewicz, Edward; Jankowska-Anyszka, Marzena

eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei

RNA

IF5

2014-06-24

OAAI

Freire, Eden R.; Vashisht, Ajay A.; Malvezzi, Amaranta M.; Zuberek, Joanna; Langousis, Gerasimos; Saada, Edwin A.; Nascimento, Janaina De F.; Stepinski, Janusz; Darzynkiewicz, Edward; Hill, Kent; Neto, Osvaldo P. De Melo; Wohlschlegel, James A.; Sturm, Nancy R.; Campbell, David A.

研究方向