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收藏The Current State of Biotransformation Science - Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends
Savaryn, John P.; Coe, Kevin; Cerny, Matthew A.; Colizza, Kevin; Moliner, Patricia; King, Lloyd; Ma, Bin; Atherton, Jim; Auclair, Adam; Cancilla, Mark T.; Eno, Marsha; Jurva, Ulrik; Yue, Qin; Zhu, Sean Xiaochun; Freiberger, Elyse; Zhong, Guo; Barlock, Ben; Nachtigall, Jonny; Laboureur, Laurent; Pusalkar, Sandeepraj; Guo, Runcong; Niehues, Michael; Hauri, Simon; Carreras, Ester Tor; Maurer, Christine; Prakash, Chandra; Jenkins, Gary J. 分享 收藏 Leveraging High-Resolution Ion Mobility-Mass Spectrometry for Cyclic Peptide Soft Spot IdentificationFawaz, Maria; Sun, Congliang; Feng, Yu; Qirjollari, Athanasia; Josien, Hubert; Debord, Daniel; Simone, Ashli; Williamson, David L.; Pearson, Kara; Gonzalez, Raymond J.; Vasicek, Lisa; Cancilla, Mark T.; Wang, Weixun; Spellman, Daniel S.; Kedia, Komal 分享 收藏 分享 收藏 分享 收藏 Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization使用纳米喷雾解吸电喷雾电离对组织中的双氯芬酸及其代谢物进行质谱成像Sanchez, Daniela Mesa; Brown, Hilary M.; Yin, Ruichuan; Chen, Bingming; Vavrek, Marissa; Cancilla, Mark T.; Zhong, Wendy; Shyong, BaoJen; Zhang, Nanyan Rena; Li, Fangbiao; Laskin, Julia 分享 收藏 分享 收藏 Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitorsHopkins, Brian T.; Bame, Eris; Bell, Noah; Bohnert, Tonika; Bowden-Verhoek, Jon K.; Bui, Minna; Cancilla, Mark T.; Conlon, Patrick; Cullen, Patrick; Erlanson, Daniel A.; Fan, Junfa; Fuchs-Knotts, Tarra; Hansen, Stig; Heumann, Stacey; Jenkins, Tracy J.; Gua, Chuck; Liu, Ying; Liu, YuTing; Lulla, Mukush; Marcotte, Douglas; Marx, Isaac; McDowell, Bob; Mertsching, Elisabeth; Negrou, Ella; Romanowski, Michael J.; Scott, Daniel; Silvian, Laura; Yang, Wenjin; Zhong, Min 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA ThioesterShang, Jackie; Tschirret-Guth, Richard; Cancilla, Mark; Samuel, Koppara; Chen, Cling; Chobanian, Harry R.; Thomas, Ann; Tong, Wei; Josien, Hubert; Buevich, Alexei V.; Mitra, Kaushik 分享 收藏 Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated DissociationNiyonsaba, Edouard; Easton, McKay W.; Feng, Erlu; Yu, Zaikuan; Zhang, Zhoupeng; Sheng, Huaming; Kong, John; Easterling, Leah F.; Milton, Jacob; Chobanian, Harry R.; Deprez, Nicholas R.; Cancilla, Mark T.; Kilaz, Gozdem; Kenttamaa, Hilkka I. 分享 收藏 Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screensHopkins, Brian T.; Bame, Eris; Bell, Noah; Bohnert, Tonika; Bowden-Verhoek, Jon K.; Bui, Minna; Cancilla, Mark T.; Conlon, Patrick; Cullen, Patrick; Erlanson, Daniel A.; Fan, Junfa; Fuchs-Knotts, Tarra; Hansen, Stig; Heumann, Stacey; Jenkins, Tracy J.; Marcotte, Douglas; McDowell, Bob; Mertsching, Elisabeth; Negrou, Ella; Otipoby, Kevin L.; Poreci, Urjana; Romanowski, Michael J.; Scott, Daniel; Silvian, Laura; Yang, Wenjin; Zhong, Min 分享 收藏 Modeling the Kinetics of Lipid-Nanoparticle-Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2Mihaila, Radu; Ruhela, Dipali; Galinski, Beverly; Card, Ananda; Cancilla, Mark; Shadel, Timothy; Kang, Jing; Tep, Samnang; Wei, Jie; Haas, R. Matthew; Caldwell, Jeremy; Flanagan, W. Michael; Kuklin, Nelly; Cherkaev, Elena; Ason, Brandon 分享 收藏 Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune CellsBrandish, Philip E.; Palmieri, Anthony; Antonenko, Svetlana; Beaumont, Maribel; Benso, Lia; Cancilla, Mark; Cheng, Mangeng; Fayadat-Dilman, Laurence; Feng, Guo; Figueroa, Isabel; Firdos, Juhi; Garbaccio, Robert; Garvin-Queen, Laura; Gately, Dennis; Geda, Prasanthi; Haines, Christopher; Hseih, SuChun; Hodges, Douglas; Kern, Jeffrey; Knudsen, Nickolas; Kwasnjuk, Kristen; Liang, Linda; Ma, Huiping; Manibusan, Anthony; Miller, Paul L.; Moy, Lily Y.; Qu, Yujie; Shah, Sanjiv; Shin, John S.; Stivers, Peter; Sun, Ying; Tomazela, Daniela; Woo, Hyun Chong; Zaller, Dennis; Zhang, Shuli; Zhang, Yiwei; Zielstorff, Mark 分享 收藏 Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug ConjugatesKern, Jeffrey C.; Cancilla, Mark; Dooney, Deborah; Kwasnjuk, Kristen; Zhang, Rena; Beaumont, Maribel; Figueroa, Isabel; Hsieh, SuChun; Liang, Linda; Tomazela, Daniela; Zhang, Jeffrey; Brandish, Philip E.; Palmieri, Anthony; Stivers, Peter; Cheng, Mangeng; Feng, Guo; Geda, Prasanthi; Shah, Sanjiv; Beck, Andrew; Bresson, Damien; Firdos, Juhi; Gately, Dennis; Knudsen, Nick; Manibusan, Anthony; Schultz, Peter G.; Sun, Ying; Garbaccio, Robert M. 分享 收藏 分享 收藏 RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in MiceWei, Jie; Jones, Jeffrey; Kang, Jing; Card, Ananda; Krimm, Michael; Hancock, Paula; Pei, Yi; Ason, Brandon; Payson, Elmer; Dubinina, Natalya; Cancilla, Mark; Stroh, Mark; Burchard, Julja; Sachs, Alan B.; Hochman, Jerome H.; Flanagan, W. Michael; Kuklin, Nelly A. 分享 收藏 Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivoKenski, Denise M.; Cooper, Abby J.; Li, Jenny J.; Willingham, Aarron T.; Haringsma, Henry J.; Young, Tracy A.; Kuklin, Nelly A.; Jones, Jeffrey J.; Cancilla, Mark T.; McMasters, Daniel R.; Mathur, Melina; Sachs, Alan B.; Flanagan, W. Michael 分享 收藏 
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