Ralph Hirschmann - Publications, H-index & Citations

Design, Synthesis, and Structural Analysis of D,L-Mixed Polypyrrolinones. 2. Macrocyclic Hexapyrrolinones

IF5

2010-06-02

OAAI

Smith, Amos B., III; Wang, Wenyong; Charnley, Adam K.; Carroll, Patrick J.; Kenesky, Craig S.; Hirschmann, Ralph

The β-D-Glucose Scaffold as a β-Turn Mimetic

IF5

2010-06-02

OAAI

Smith, Amos B., III; Xiong, Hui; Charnley, Adam K.; Brenner, Meinrad; Mesaros, Eugen F.; Kenesky, Craig S.; Di Costanzo, Luigi; Christianson, David W.; Hirschmann, Ralph

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2009-07-22

OAAI

Hirschmann, Ralph F.; Nicolaou, K. C.; Angeles, Angie R.; Chen, Jason S.; Smith, Amos B., III

Catechol:: A minimal scaffold for non-peptide peptidomimetics of the i+1 and i+2 positions of the β-turn of somatostatin

Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor

IF5

2006-09-02

PREAI

Mowery, Brendan P.; Prasad, Vidya; Kenesky, Craig S.; Angeles, Angie R.; Taylor, Laurie L.; Feng, Jin-Jye; Chen, Wen-Long; Lin, Atsui; Cheng, Fong-Chi; Smith, Amos B., III; Hirschmann, Ralph

Replacement of Phe6, Phe7, and Phe11 of d-Trp8-somatostatin-14 with l-pyrazinylalanine.: Predicted and observed effects on binding affinities at hSST2 and hSST4.: An unexpected effect of the chirality of Trp8 on NMR spectra in methanol

IF5

2006-03-29

PREAI

Foister, S; Taylor, LL; Feng, JJ; Chen, WL; Lin, A; Cheng, FC; Smith, AB; Hirschmann, R

Synthesis and binding affinities of novel SRIF-mimicking β-D-glucosides satisfying the requirement for a π-cloud at C1

IF6.8

2005-05-21

PREAI

Neelamkavil, S; Arison, B; Birzin, E; Feng, JJ; Chen, KH; Lin, A; Cheng, FC; Taylor, L; Thornton, ER; Smith, AB; Hirschmann, R

Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics

IF5

2005-02-23

PREAI

Angeles, AR; Neagu, I; Birzin, ET; Thornton, ER; Smith, AB; Hirschmann, R

Novel chimeric scaffolds to extend the exploration of receptor space:: Hybrid β-D-glucose-benzoheterodiazepine structures for broad screening.: Effect of amide alkylation on the course of cyclization reactions

IF5

2005-01-08

PREAI

Smith, AB; Charnley, AK; Mesaros, EF; Kikuchi, O; Wang, WY; Benowitz, A; Chu, CL; Feng, JJ; Chen, KH; Lin, A; Cheng, FC; Taylor, L; Hirschmann, R

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2003-12-19

PREAI

Abrous, L; Jokiel, PA; Friedrich, SR; Hynes, J; Smith, AB; Hirschmann, R

Effects of Heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors

IF6.8

2003-04-15

PREAI

Prasad, V; Birzin, ET; McVaugh, CT; van Rijn, RD; Rohrer, SP; Chicchi, G; Underwood, DJ; Thornton, ER; Smith, AB; Hirschmann, R

SYNTHESIS OF CORTISONE-21 PHOSPHATE

IF6.8

2003-04-09

PREAI

Smith, AB; Cantin, LD; Pasternak, A; Guise-Zawacki, L; Yao, WQ; Charnley, AK; Barbosa, J; Sprengeler, PA; Hirschmann, R; Munshi, S; Olsen, DB; Schleif, WA; Kuo, LC

DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT

IF15.6

2002-05-01

PREAI

CUTLER, FA; CONBERE, JP; LUKES, RM; FISHER, JF; MERTEL, HE; HIRSCHMANN, R; CHEMERDA, JM; SARETT, LH; PFISTER, K

PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORT

IF6.8

2002-05-01

PREAI

SMITH, AB; HIRSCHMANN, R; PASTERNAK, A; AKAISHI, R; GUZMAN, MC; JONES, DR; KEENAN, TP; SPRENGELER, PA; DARKE, PL; EMINI, EA; HOLLOWAY, MK; SCHLEIF, WA

NONPEPTIDAL PEPTIDOMIMETICS WITH A BETA-D-GLUCOSE SCAFFOLDING - A PARTIAL SOMATOSTATIN AGONIST BEARING A CLOSE STRUCTURAL RELATIONSHIP TO A POTENT, SELECTIVE SUBSTANCE-P ANTAGONIST

IF15.6

2002-05-01

PREAI

SMITH, AB; HIRSCHMANN, R; PASTERNAK, A; GUZMAN, MC; YOKOYAMA, A; SPRENGELER, PA; DARKE, PL; EMINI, EA; SCHLEIF, WA

THE 1ST DESIGN AND SYNTHESIS OF A STEROIDAL PEPTIDOMIMETIC - THE POTENTIAL VALUE OF PEPTIDOMIMETICS IN ELUCIDATING THE BIOACTIVE CONFORMATION OF PEPTIDE LIGANDS

IF15.6

2002-05-01

437

PREAI

HIRSCHMANN, R; NICOLAOU, KC; PIETRANICO, S; SALVINO, J; LEAHY, EM; SPRENGELER, PA; FURST, G; SMITH, AB; STRADER, CD; CASCIERI, MA; CANDELORE, MR; DONALDSON, C; VALE, W; MAECHLER, L

GENERAL SYNTHESIS OF 4,5-UNSATURATED 2-OXASTEROIDS - SYNTHESIS OF 2-OXACORTISOL

IF15.6

2002-05-01

109

PREAI

HIRSCHMANN, R; SPRENGELER, PA; KAWASAKI, T; LEAHY, JW; SHAKESPEARE, WC; SMITH, AB