David W. Christianson - Publications, H-index & Citations

David W. Christianson

University of Pennsylvania

83H指数

613论文数

2.4W被引数

收录论文 143

发表时间

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions 改进的蛋白质半合成技术使硫酰胺对β-折叠相互作用的破坏的生物物理研究成为可能

Biochemistry

IF3

2026-09-01

PREAI

Evan S. K. Yanagawa; Kristen E. Fiore; Denver Y. Francis; Aiden Lesneski; Yanan Chang; Benjamin W. Roose; David W. Christianson; Kohei Sato; E. James Petersson

Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor 鉴定组蛋白去乙酰化酶6抑制剂的机制性结合模式

Nature Communications

IF15.7

2026-06-05

OAAI

Daniel A. Rodrigues; Yu Wang; Juana Goulart Stollmaier; Graeme P. Sullivan; Cian D’Arcy; Aisling Y. Coughlan; Andrew Roe; Linda Bíró; Paris R. Watson; Jeremy D. Osko; Brendan Twamley; Kieran Wynne; Gerard Cagney; Péter Buglyó; Yanli Liu; Darren M. Griffith; David W. Christianson; Tríona Ní Chonghaile

Covalent Binding of the Boronic Acid-Based Inhibitor GSK4394835A to Phosphodiesterase 3B, a Drug Target for Cardiovascular Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-12-01

PREAI

Eaton, Samuel A.; Christianson, David W.

Structure and Mechanism of Avermitilol Synthase, a Sesquiterpene Cyclase That Generates a Highly Strained 6-6-3 Tricyclic Alcohol 阿维菌醇合酶的结构与机制，一种能生成高度张力的6-6-3三环醇的倍半萜环化酶

BIOCHEMISTRY

IF3

2025-12-01

PREAI

Gaynes, Matthew N.; Osika, Kristin R.; Christianson, David W.

Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate Is Subject to Redox Modulation 硒氰酸盐对组蛋白去乙酰化酶6的机制性抑制受氧化还原调节

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-02-17

PREAI

Stollmaier, Juana Goulart; Czarnecki, Briana Abigail R.; Christianson, David W.

Engineering substrate channeling in a bifunctional terpene synthase

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-10-04

OAAI

Wenger, Eliott S.; Schultz, Kollin; Marmorstein, Ronen; Christianson, David W.

Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-09-05

PREAI

Stollmaier, Juana Goulart; Watson, Paris R.; Christianson, David W.

Stimulation of caudal inferior and middle frontal gyri disrupts planning during spoken interaction

CURRENT BIOLOGY

IF7.5

2024-06-01

PREAI

Castellucci, Gregg A.; Kovach, Christopher K.; Tabasi, Farhad; Christianson, David; Greenlee, Jeremy D. W.; Long, Michael A.

Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2024-03-26

PREAI

Christianson, David W.

Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2024-03-01

PREAI

Gaynes, Matthew N.; Ronnebaum, Trey A.; Schultz, Kollin; Faylo, Jacque L.; Marmorstein, Ronen; Christianson, David W.

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-10-30

OAAI

Sinatra, Laura; Vogelmann, Anja; Friedrich, Florian; Tararina, Margarita A.; Neuwirt, Emilia; Colcerasa, Arianna; Koenig, Philipp; Toy, Lara; Yesiloglu, Talha Z.; Hilscher, Sebastian; Gaitzsch, Lena; Papenkordt, Niklas; Zhai, Shiyang; Zhang, Lin; Romier, Christophe; Einsle, Oliver; Sippl, Wolfgang; Schutkowski, Mike; Gross, Olaf; Bendas, Gerd; Christianson, David W.; Hansen, Finn K.; Jung, Manfred; Schiedel, Matthias

Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-10-02

OAAI

Ko''nig, Beate; Watson, Paris R.; Ressing, Nina; Cragin, Abigail D.; Scha''ker-Hu''bner, Linda; Christianson, David W.; Hansen, Finn K.

Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-10-01

OAAI

Watson, Paris R.; Stollmaier, Juana Goulart; Christianson, David W.

Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-11-09

OAAI

Ressing, Nina; Schliehe-Diecks, Julian; Watson, Paris R.; Soennichsen, Melf; Cragin, Abigail D.; Schoeler, Andrea; Yang, Jing; Schaeker-Huebner, Linda; Borkhardt, Arndt; Christianson, David W.; Bhatia, Sanil; Hansen, Finn K.

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout br

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-10-06

OAAI

Steimbach, Raphael R.; Herbst-Gervasoni, Corey J.; Lechner, Severin; Stewart, Tracy Murray; Klinke, Glynis; Ridinger, Johannes; Geraldy, Magalie N. E.; Tihanyi, Gergely; Foley, Jackson R.; Uhrig, Ulrike; Kuster, Bernhard; Poschet, Gernot; Casero, Robert A., Jr.; Medard, Guillaume; Oehme, Ina; Christianson, David W.; Gunkel, Nikolas; Miller, Aubry K.

Structural Analysis of a Non-canonical Terpene Synthase

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Tararina, Margarita A.; Yee, Danielle A.; Tang, Yi; Christianson, David W.

A Novel Zinc Binding Group for HDAC6 Inhibition

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Cragin, Abigail; Watson, Paris R.; Konig, Beate; Hansen, Finn K.; Christianson, David W.

Aromatic C-F Interactions Influence Binding Mode of Inhibitors in HDAC6

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Watson, Paris R.; Hooker, Jacob; Christianson, David W.

Assembly-line catalysis in bifunctional terpene synthases: (+)-Copalyl diphosphate synthase from fungal Penicillium species

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Ronnebaum, Trey A.; Eaton, Samuel A.; Brackhahn, Emily A. E.; Faylo, Jacque L.; Gupta, Kushol; Christianson, David W.

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-04-01

OAAI

Zeyen, Patrik; Zeyn, Yanira; Herp, Daniel; Mahmoudi, Fereshteh; Yesiloglu, Talha Z.; Erdmann, Frank; Schmidt, Matthias; Robaa, Dina; Romier, Christophe; Ridinger, Johannes; Herbst-Gervasoni, Corey J.; Christianson, David W.; Oehme, Ina; Jung, Manfred; Kraemer, Oliver H.; Sippl, Wolfgang

研究方向