未登录 A phase 1 study of abemaciclib, a CDK 4/6 inhibitor, with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) Cash, Thomas; Aguilera, Dolly; He, Zhulin; Schink, Melissa; Sykes, Amanda; Pitou, Celine; Connelly, Erin; Eaton, Bree; Esiashvili, Natia; Mangum, Ross; Macy, Margaret E.; Castellino, Robert C.; Fangusaro, Jason; MacDonald, Tobey J.; Wetmore, Cynthia; Hoffman, Lindsey 分享 收藏
Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor Upadhyaya, Santhosh A.; Campagne, Olivia; Billups, Catherine A.; Orr, Brent A.; Onar-Thomas, Arzu; Tatevossian, Ruth G.; Mostafavi, Roya; Myers, Jason R.; Vinitsky, Anna; Moreira, Daniel C.; Lindsay, Holly B.; Kilburn, Lindsay; Baxter, Patricia; Smith, Amy; Crawford, John R.; Partap, Sonia; Bendel, Anne E.; Aguilera, Dolly G.; Nichols, Kim E.; Rampersaud, Evadnie; Ellison, David W.; Klimo, Paul, Jr.; Patay, Zoltan; Robinson, Giles W.; Broniscer, Alberto; Stewart, Clinton F.; Wetmore, Cynthia; Gajjar, Amar 分享 收藏
Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor Arunachalam, Sasi; Szlachta, Karol; Brady, Samuel W.; Ma, Xiaotu; Ju, Bensheng; Shaner, Bridget; Mulder, Heather L.; Easton, John; Raphael, Benjamin J.; Myers, Matthew; Tinkle, Christopher; Allen, Sariah J.; Orr, Brent A.; Wetmore, Cynthia J.; Baker, Suzanne J.; Zhang, Jinghui 分享 收藏
First in human phase 1 dose escalation and expansion study of the safety and pharmacokinetics of the oral CDK7 inhibitor XL102 as a single-agent and in combination therapy in patients with inoperable locally advanced or metastatic solid tumors, including breast cancer Patnaik, Amita; Barve, Minal; Bhave, Manali; Subbiah, Vivek; Atwal, Sumandeep; Sharma, Keerti; Scheffold, Christian; Wetmore, Cynthia; Shapiro, Geoffrey 分享 收藏
Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG Tinkle, Christopher L.; Broniscer, Alberto; Chiang, Jason; Campagne, Olivia; Huang, Jie; Orr, Brent A.; Li, Xiaoyu; Patay, Zoltan; Zhang, Jinghui; Baker, Suzanne J.; Merchant, Thomas E.; Jain, Vinay; Onar-Thomas, Arzu; Stewart, Clinton F.; Wetmore, Cynthia; Gajjar, Amar 分享 收藏
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma He, Chen; Xu, Ke; Zhu, Xiaoyan; Dunphy, Paige S.; Gudenas, Brian; Lin, Wenwei; Twarog, Nathaniel; Hover, Laura D.; Kwon, Chang-Hyuk; Kasper, Lawryn H.; Zhang, Junyuan; Li, Xiaoyu; Dalton, James; Jonchere, Barbara; Mercer, Kimberly S.; Currier, Duane G.; Caufield, William; Wang, Yingzhe; Xie, Jia; Broniscer, Alberto; Wetmore, Cynthia; Upadhyaya, Santhosh A.; Qaddoumi, Ibrahim; Klimo, Paul; Boop, Frederick; Gajjar, Amar; Zhang, Jinghui; Orr, Brent A.; Robinson, Giles W.; Monje, Michelle; Freeman, Burgess B., III; Roussel, Martine F.; Northcott, Paul A.; Chen, Taosheng; Rankovic, Zoran; Wu, Gang; Chiang, Jason; Tinkle, Christopher L.; Shelat, Anang A.; Baker, Suzanne J. 分享 收藏
Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors Wongthida, Phonphimon; Schuelke, Matthew R.; Driscoll, Christopher B.; Kottke, Timothy; Thompson, Jill M.; Tonne, Jason; Stone, Cathy; Huff, Amanda L.; Wetmore, Cynthia; Davies, James A.; Parker, Alan L.; Evgin, Laura; Vile, Richard G. 分享 收藏
Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features Sloan, Emily A.; Hilz, Stephanie; Gupta, Rohit; Cadwell, Cathryn; Ramani, Biswarathan; Hofmann, Jeffrey; Kline, Cassie N.; Banerjee, Anu; Reddy, Alyssa; Bush, Nancy Ann Oberheim; Chang, Susan; Braunstein, Steve; Chang, Edward F.; Raffel, Corey; Gupta, Nalin; Sun, Peter P.; Kim, John Y. H.; Moes, Gregory; Alva, Elizabeth; Li, Rong; Bruggers, Carol S.; Alashari, Mouied; Wetmore, Cynthia; Garg, Shipra; Dishop, Megan; Van Ziffle, Jessica; Onodera, Courtney; Devine, Patrick; Grenert, James P.; Lee, Julieann C.; Phillips, Joanna J.; Pekmezci, Melike; Tihan, Tarik; Bollen, Andrew W.; Berger, Mitchel S.; Costello, Joseph F.; Perry, Arie; Solomon, David A. 分享 收藏
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy Driscoll, Christopher B.; Schuelke, Matthew R.; Kottke, Timothy; Thompson, Jill M.; Wongthida, Phonphimon; Tonne, Jason M.; Huff, Amanda L.; Miller, Amber; Shim, Kevin G.; Molan, Amy; Wetmore, Cynthia; Selby, Peter; Samson, Adel; Harrington, Kevin; Pandha, Hardev; Melcher, Alan; Pulido, Jose S.; Harris, Reuben; Evgin, Laura; Vile, Richard G. 分享 收藏
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells Montoya, Justin J.; Turnidge, Megan A.; Wai, Daniel H.; Patel, Apurvi R.; Lee, David W.; Gokhale, Vijay; Hurley, Laurence H.; Arceci, Robert J.; Wetmore, Cynthia; Azorsa, David O. 分享 收藏
Phase 1 study of abemaciclib in children with recurrent and refractory solid tumors including malignant brain tumors Cash, Thomas; Aguilera, Dolly; Macy, Margaret E.; Hoffman, Lindsey; Dorris, Kathleen; McCracken, Courtney; Hanberry, Bradley; Castellino, Robert; MacDonald, Tobey; Wetmore, Cynthia 分享 收藏
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H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo (vol 137, pg 637, 2019) Silveira, Andre B.; Kasper, Lawryn H.; Fan, Yiping; Jin, Hongjian; Wu, Gang; Shaw, Timothy I.; Zhu, Xiaoyan; Larson, Jon D.; Easton, John; Shao, Ying; Yergeau, Donald A.; Rosencrance, Celeste; Boggs, Kristy; Rusch, Michael C.; Ding, Liang; Zhang, Junyuan; Finkelstein, David; Noyes, Rachel M.; Russell, Brent L.; Xu, Beisi; Broniscer, Alberto; Wetmore, Cynthia; Pounds, Stanley B.; Ellison, David W.; Zhang, Jinghui; Baker, Suzanne J. 分享 收藏
H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo Silveira, Andre B.; Kasper, Lawryn H.; Fan, Yiping; Jin, Hongjian; Wu, Gang; Shaw, Timothy I.; Zhu, Xiaoyan; Larson, Jon D.; Easton, John; Shao, Ying; Yergeau, Donald A.; Rosencrance, Celeste; Boggs, Kristy; Rusch, Michael C.; Ding, Liang; Zhang, Junyuan; Finkelstein, David; Noyes, Rachel M.; Russell, Brent L.; Xu, Beisi; Broniscer, Alberto; Wetmore, Cynthia; Pounds, Stanley B.; Ellison, David W.; Zhang, Jinghui; Baker, Suzanne J. 分享 收藏
Phase 1 study of the EZH2 inhibitor, tazemetostat, in children with relapsed or refractory INI1-negative tumors including rhabdoid tumors, epithelioid sarcoma, chordoma, and synovial sarcoma Chi, Susan; Fouladi, Maryam; Shukla, Neerav; Bourdeaut, Franck; Margol, Ashley; Makin, Guy; McCowage, Geoff; Wetmore, Cynthia; Macy, Margaret; Laetsch, Ted; Hargrave, Darren; Pinto, Navin; Yi, Joanna; Ebb, Dave; Robinson, Giles; Roche, Maria; Suttle, Benjamin; Clawson, Alicia; Ho, Peter; Rodstrom, Jill; Daigle, Scott; Nysom, Karsten 分享 收藏
STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions Desai, Ami V.; Brodeur, Garrett M.; Foster, Jennifer; Shusterman, Suzanne; Sabnis, Amit J.; Macy, Magaret; Wetmore, Cynthia; Basu, Ellen; Hornby, Zachary; Esquibel, Vanessa; Maneval, Edna Chow; Multani, Pratik S.; Fox, Elizabeth 分享 收藏
An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN) 贝伐单抗和拉帕替尼治疗儿童复发性或难治性室管膜瘤的开放标签、两阶段、II期研究: 室管膜瘤研究网络协作性研究 (CERN) DeWire, Mariko; Fouladi, Maryam; Turner, David C.; Wetmore, Cynthia; Hawkins, Cynthia; Jacobs, Carmen; Yuan, Ying; Liu, Diane; Goldman, Stewart; Fisher, Paul; Rytting, Michael; Bouffet, Eric; Khakoo, Yasmin; Hwang, Eugene I.; Foreman, Nicholas; Stewart, Clinton F.; Gilbert, Mark R.; Gilbertson, Richard; Gajjar, Amar 分享 收藏
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A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors: a pediatric brain tumor consortium study 在难治性原发性中枢神经系统肿瘤的儿科患者中，恩扎妥林的1期和药代动力学研究: 儿科脑肿瘤联盟研究 Kilburn, Lindsay B.; Kocak, Mehmet; Decker, Rodney L.; Wetmore, Cynthia; Chintagumpala, Murali; Su, Jack; Goldman, Stewart; Banerjee, Anuradha; Gilbertson, Richard; Fouladi, Maryam; Kun, Larry; Boyett, James M.; Blaney, Susan M. 分享 收藏
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