未登录 Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor Rosenquist, Asa; Samuelsson, Bertil; Johansson, Per-Ola; Cummings, Maxwell D.; Lenz, Oliver; Raboisson, Pierre; Simmen, Kenny; Vendeville, Sandrine; de Kock, Herman; Nilsson, Magnus; Horvath, Andras; Kalmeijer, Ronald; de la Rosa, Guy; Beumont-Mauviel, Maria 分享 收藏
Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase Jonckers, Tim H. M.; Vandyck, Koen; Vandekerckhove, Leen; Hu, Lili; Tahri, Abdellah; Van Hoof, Steven; Lin, Tse-I; Vijgen, Leen; Berke, Jan Martin; Lachau-Durand, Sophie; Stoops, Bart; Leclercq, Laurent; Fanning, Gregory; Samuelsson, Bertil; Nilsson, Magnus; Rosenquist, Asa; Simmen, Kenny; Raboisson, Pierre 分享 收藏
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Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors Wu, Xiongyu; Ohrngren, Per; Joshi, Advait A.; Trejos, Alejandro; Persson, Magnus; Arvela, Riina K.; Wallberg, Hans; Vrang, Lotta; Rosenquist, Asa; Samuelsson, Bertil B.; Unge, Johan; Larhed, Mats 分享 收藏
Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase Berke, Jan Martin; Vijgen, Leen; Lachau-Durand, Sophie; Powdrill, Megan H.; Rawe, Svea; Sjuvarsson, Elena; Eriksson, Staffan; Goette, Matthias; Fransen, Els; Dehertogh, Pascale; Van den Eynde, Christel; Leclercq, Laurent; Jonckers, Tim H. M.; Raboisson, Pierre; Nilsson, Magnus; Samuelsson, Bertil; Rosenquist, Asa; Fanning, Gregory C.; Lin, Tse-I 分享 收藏
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2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase Jonckers, Tim H. M.; Lin, Tse-I; Buyck, Christophe; Lachau-Durand, Sophie; Vandyek, Koen; Van Hoof, Steven; Vandekerckhove, Leen A. M.; Hu, Lili; Berke, Jan Martin; Vijgen, Leen; Dillen, Lieve L. A.; Cummings, Maxwell D.; de Kock, Herman; Nilsson, Magnus; Sund, Christian; Rydegard, Christina; Samuelsson, Bertil; Rosenquist, Asa; Fanning, Gregory; Van Emelen, Kristof; Simmen, Kenneth; Raboisson, Pierre 分享 收藏
Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core Wangsell, Fredrik; Gustafsson, Karin; Kvarnstrom, Ingemar; Borkakoti, Neera; Edlund, Michael; Jansson, Katarina; Lindberg, Jimmy; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil 分享 收藏
Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target Cummings, Maxwell D.; Lindberg, Jimmy; Lin, Tse-I; de Kock, Herman; Lenz, Oliver; Lilja, Elisabet; Fellander, Sara; Baraznenok, Vera; Nystrom, Susanne; Nilsson, Magnus; Vrang, Lotta; Edlund, Michael; Rosenquist, Asa; Samuelsson, Bertil; Raboisson, Pierre; Simmen, Kenneth 分享 收藏
Design and Synthesis of Potent and Selective BACE-1 Inhibitors Bjorklund, Catarina; Oscarson, Stefan; Benkestock, Kurt; Borkakoti, Neera; Jansson, Katarina; Lindberg, Jimmy; Vrang, Lotta; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil 分享 收藏
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HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells Mahalingam, A. K.; Axelsson, Linda; Ekegren, Jenny K.; Wannberg, Johan; Kihlstrom, Jacob; Unge, Torsten; Wallberg, Hans; Samuelsson, Bertil; Larhed, Mats; Hallberg, Anders 分享 收藏
In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor Lin, Tse-I; Lenz, Oliver; Fanning, Gregory; Verbinnen, Thierry; Delouvroy, Frederic; Scholliers, Annick; Vermeiren, Katrien; Rosenquist, Asa; Edlund, Michael; Samuelsson, Bertil; Vrang, Lotta; de Kock, Herman; Wigerinck, Piet; Raboisson, Pierre; Simmen, Kenneth 分享 收藏
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity Ayesa, Susana; Lindquist, Charlotta; Agback, Tatiana; Benkestock, Kurt; Classon, Bjoern; Henderson, Ian; Hewitt, Ellen; Jansson, Katarina; Kallin, Anders; Sheppard, Dave; Samuelsson, Bertil 分享 收藏
Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues Back, Marcus; Nyhlen, Jonas; Kvarnstrom, Ingemar; Appelgren, Sara; Borkakoti, Neera; Jansson, Katarina; Lindberg, Jimmy; Nystrom, Susanne; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil 分享 收藏
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic(vol 51, pg 1054, 2008) Wu, Xiongyu; Ohrngren, Per; Ekegren, Jenny K.; Unge, Johan; Unge, Torsten; Wallberg, Hans; Samuelsson, Bertil; Hallberg, Anders; Larhed, Mats 分享 收藏
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