未登录 Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ Li, Guisheng; Tan, Zhulin; Xu, Yibo; Sidhu, Kanwar P. S.; Qu, Bo; Herbage, Melissa A.; Eriksson, Magnus C.; Zeng, Xingzhong; Busacca, Carl A.; Desrosiers, Jean-Nicolas; Hampel, Thomas; Niemeier, Oliver; Reichel, Carsten; Dang, Mai Thi Quynh; Schoerer, Marvin; Kemmer, Dirk; Eick, Melanie; Werle, Holger; Kim, Soojin; Li, Zhibin; Venkatraman, Shankar; Jia, Lanqi; Claremon, David A.; Fuchs, Klaus; Heine, Niklas; Byrne, Denis; Narayanan, Bikshandarkoil; Sarvestani, Max; Johnson, Joe; Premasiri, Ajith; Nummy, Larry J.; Lorenz, Jon C.; Haddad, Nizar; Gonnella, Nina C.; Pennino, Scott; Krawiec, Mariusz; Senanayake, Chris H.; Buono, Frederic; Lee, Heewon; Hossain, Azad; Song, Jinhua J.; Reeves, Jonathan T. 分享 收藏
Carbamoyl Anion Addition to Azirines Kerner, Michael J.; Kuttruff, Christian A.; Chevliakov, Maxim; Buono, Frederic G.; Gao, Donghong A.; Krawiec, Mariusz; Busacca, Carl A.; Senanayake, Chris H.; Wipf, Peter; Reeves, Jonathan T. 分享 收藏
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Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes Liu, Mingyu; Tang, Tianhua; Apolinar, Omar; Matsuura, Rei; Busacca, Carl A.; Qu, Bo; Fandrick, Daniel R.; Zatolochnaya, Olga, V; Senanayake, Chris H.; Song, Jinhua J.; Engle, Keary M. 分享 收藏
Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420 Patel, Nitinchandra D.; Wei, Xudong; Byrne, Denis; Narayanan, Bikshandarkoil A.; Pennino, Scott; Sarvestani, Max; Saha, Anjan; Haddad, Nizar; Kapadia, Suresh; Lorenz, Jon C.; DeCroos, Philomen; Ye, Andrew; Lee, Heewon; Grinberg, Nelu; Hossain, Azad; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
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Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation Sieber, Joshua D.; Rodriguez, Sonia; Frutos, Rogelio; Buono, Frederic; Zhang, Yongda; Li, Ning; Qu, Bo; Premasiri, Ajith; Li, Zhibin; Han, Zhengxu S.; Xu, Yibo; Byrne, Denis; Haddad, Nizar; Lorenz, Jon; Grinberg, Nelu; Kurouski, Dmitry; Lee, Heewon; Narayanan, Bikshandarkoil; Nummy, Laurence; Mulder, Jason; Brown, Jack D.; Granger, Alice; Gao, Joe; Krawiec, Mariusz; Williams, Zeena; Pennino, Scott; Song, Jinhua J.; Hossain, Azad; Yee, Nathan K.; Busacca, Carl; Roschangar, Frank; Xin, Yanchao; Mao, Zhantong; Zhang, Xinzhu; Hong, Yaping; Senanayake, Chris H. 分享 收藏
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Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor Mulder, Jason A.; Gao, Joe; Fandrick, Keith R.; Zeng, Xingzhong; Desrosiers, Jean-Nicolas; Patel, Nitinchandra D.; Li, Zhibin; Rodriguez, Sonia; Lorenz, Jon C.; Wang, Jun; Ma, Shengli; Fandrick, Daniel R.; Grinberg, Nelu; Lee, Heewon; Bosanac, Todd; Takahashi, Hidenori; Chen, Zhidong; Bartolozzi, Alessandra; Nemoto, Peter; Busacca, Carl A.; Song, Jinhua J.; Yee, Nathan K.; Mahoney, Paige E.; Senanayake, Chris H. 分享 收藏
Enantioselective Nickel-Catalyzed Mizoroki Heck Cyclizations To Generate Quaternary Stereocenters Desrosiers, Jean-Nicolas; Wen, Jialin; Tcyrulnikov, Sergei; Biswas, Soumik; Qu, Bo; Hie, Liana; Kurouski, Dmitry; Wu, Ling; Grinberg, Nelu; Haddad, Nizar; Busacca, Carl A.; Yee, Nathan K.; Song, Jinhua J.; Garg, Neil K.; Zhang, Xumu; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles Malapit, Christian A.; Caldwell, Donald R.; Luvaga, Irungu K.; Reeves, Jonathan T.; Volchkov, Ivan; Gonnella, Nina C.; Han, Zhengxu S.; Busacca, Carl A.; Howell, Amy R.; Senanayake, Chris H. 分享 收藏
Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ and Empirically Derived Systematic Error Correction Terms: A Computational Small Molecule Structure Elucidation Method Xin, Dongyue; Sader, C. Avery; Chaudhary, Om; Jones, Paul-James; Wagner, Klaus; Tautermann, Christofer S.; Yang, Zheng; Busacca, Carl A.; Saraceno, Reginaldo A.; Fandrick, Keith R.; Gonnella, Nina C.; Horspool, Keith; Hansen, Gordon; Senanayake, Chris H. 分享 收藏
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Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy Poly-faldaprevir的结构阐明: 使用固态和溶液核磁共振谱解决的聚合物主链 Gonnella, Nina C.; Busacca, Carl A.; Zhang, Li; Saha, Anjan; Wu, Jiang-Ping; Li, Guisheng; Davis, Mark; Offerdahl, Thomas; Jones, Paul-James; Herfurth, Lars; Reddig, Tim; Wagner, Klaus; Niemann, Michael; Werthmann, Ulrike; Grupe, Julia; Roos, Helmut; Reckzuegel, Gaby; Ding, Andreas 分享 收藏
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Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid Patel, Nitinchandra D.; Zhang, Yongda; Gao, Joe; Sidhu, Kanwar; Lorenz, Jon C.; Fandrick, Keith R.; Mulder, Jason A.; Herbage, Melissa A.; Li, Zhibin; Ma, Shengli; Lee, Heewon; Grinberg, Nelu; Song, Jinhua J.; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
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