未登录 Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin) Frutos, Rogelio; Tampone, Thomas G.; Mulder, Jason; Gao, Joe; Sieber, Joshua D.; Rodriguez, Sonia; Haddad, Nizar; Baer, Katrin; Brown, Jack; Yang, Bing-Shiou; Giovannini, Riccardo; Song, Jinhua J.; Grinberg, Nelu; Lee, Heewon; Senanayake, Chris H. 分享 收藏
Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420 Patel, Nitinchandra D.; Wei, Xudong; Byrne, Denis; Narayanan, Bikshandarkoil A.; Pennino, Scott; Sarvestani, Max; Saha, Anjan; Haddad, Nizar; Kapadia, Suresh; Lorenz, Jon C.; DeCroos, Philomen; Ye, Andrew; Lee, Heewon; Grinberg, Nelu; Hossain, Azad; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
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Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis (vol 8, pg 10190, 2018) Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis 用于四邻位取代的联芳基合成的Pd催化不对称suzuki-miyaura和Negishi交叉偶联反应的计算辅助机理研究和发展 Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, B. Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation Sieber, Joshua D.; Rodriguez, Sonia; Frutos, Rogelio; Buono, Frederic; Zhang, Yongda; Li, Ning; Qu, Bo; Premasiri, Ajith; Li, Zhibin; Han, Zhengxu S.; Xu, Yibo; Byrne, Denis; Haddad, Nizar; Lorenz, Jon; Grinberg, Nelu; Kurouski, Dmitry; Lee, Heewon; Narayanan, Bikshandarkoil; Nummy, Laurence; Mulder, Jason; Brown, Jack D.; Granger, Alice; Gao, Joe; Krawiec, Mariusz; Williams, Zeena; Pennino, Scott; Song, Jinhua J.; Hossain, Azad; Yee, Nathan K.; Busacca, Carl; Roschangar, Frank; Xin, Yanchao; Mao, Zhantong; Zhang, Xinzhu; Hong, Yaping; Senanayake, Chris H. 分享 收藏
Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution Zatolochnaya, Olga V.; Rodriguez, Sonia; Zhang, Yongda; Lao, Kendricks S.; Tcyrulnikov, Sergei; Li, Guisheng; Wang, Xiao-Jun; Qu, Bo; Biswas, Soumik; Mangunuru, Hari P. R.; Rivalti, Daniel; Sieber, Joshua D.; Desrosiers, Jean-Nicolas; Leung, Joyce C.; Grinberg, Nelu; Lee, Heewon; Haddad, Nizar; Yee, Nathan K.; Song, Jinhua J.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
P-Stereogenic Chiral Phosphine-Palladium Complex Catalyzed Enantioselective Synthesis of Phosphoryl-Substituted Atropisomeric Vinylarenes P-立体手性膦-钯配合物催化磷酰基取代的阻变异构乙烯基芳烃的对映选择性合成 Wu, Hao; Han, Zhengxu S.; Qu, Bo; Wang, Dan; Zhang, Yongda; Xu, Yibo; Grinberg, Nelu; Lee, Heewon; Song, Jinhua J.; Roschangar, Frank; Wang, Guijun; Senanayake, Chris H. 分享 收藏
Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor Mulder, Jason A.; Gao, Joe; Fandrick, Keith R.; Zeng, Xingzhong; Desrosiers, Jean-Nicolas; Patel, Nitinchandra D.; Li, Zhibin; Rodriguez, Sonia; Lorenz, Jon C.; Wang, Jun; Ma, Shengli; Fandrick, Daniel R.; Grinberg, Nelu; Lee, Heewon; Bosanac, Todd; Takahashi, Hidenori; Chen, Zhidong; Bartolozzi, Alessandra; Nemoto, Peter; Busacca, Carl A.; Song, Jinhua J.; Yee, Nathan K.; Mahoney, Paige E.; Senanayake, Chris H. 分享 收藏
Enantioselective Nickel-Catalyzed Mizoroki Heck Cyclizations To Generate Quaternary Stereocenters Desrosiers, Jean-Nicolas; Wen, Jialin; Tcyrulnikov, Sergei; Biswas, Soumik; Qu, Bo; Hie, Liana; Kurouski, Dmitry; Wu, Ling; Grinberg, Nelu; Haddad, Nizar; Busacca, Carl A.; Yee, Nathan K.; Song, Jinhua J.; Garg, Neil K.; Zhang, Xumu; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
Synthesis of P-Chiral Dihydrobenzooxaphosphole Core for BI Ligands in Asymmetric Transformations Li, Guisheng; Wang, Xiao-Jun; Zhang, Yongda; Tan, Zhulin; DeCroos, Philomen; Lorenz, Jon C.; Wei, Xudong; Grinberg, Nelu; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
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Copper-Catalyzed Asymmetric Propargylation of Cyclic Aldimines Fandrick, Daniel R.; Hart, Christine A.; Okafor, Ifeanyi S.; Mercadante, Michael A.; Sanyal, Sanjit; Masters, James T.; Sarvestani, Max; Fandrick, Keith R.; Stockdill, Jennifer L.; Grinberg, Nelu; Gonnella, Nina; Lee, Heewon; Senanayake, Chris H. 分享 收藏
Reengineered BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki-Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor Haddad, Nizar; Mangunuru, Hari P. R.; Fandrick, Keith R.; Qu, Bo; Sieber, Joshua D.; Rodriguez, Sonia; Desrosiers, Jean-Nicolas; Patel, Nitinchandra D.; Lee, Heewon; Kurouski, Dmitry; Grinberg, Nelu; Yee, Nathan K.; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏
Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts Qu, Bo; Mangunuru, Hari P. R.; Wei, Xudong; Fandrick, Keith R.; Desrosiers, Jean-Nicolas; Sieber, Joshua D.; Kurouski, Dmitry; Haddad, Nizar; Samankumara, Lalith P.; Lee, Heewon; Savoie, Jolaine; Ma, Shengli; Grinberg, Nelu; Sarvestani, Max; Yee, Nathan K.; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏
Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions 通过镍催化的Heck环化反应构建四元立体中心 Desrosiers, Jean-Nicolas; Hie, Liana; Biswas, Soumik; Zatolochnaya, Olga V.; Rodriguez, Sonia; Lee, Heewon; Grinberg, Nelu; Haddad, Nizar; Yee, Nathan K.; Garg, Neil K.; Senanayake, Chris H. 分享 收藏
Rhodium-Catalyzed Asymmetric Allenylation of Sulfonylimines and Application to the Stereospecific Allylic Allenylation Sieber, Joshua D.; Angeles-Dunham, Veronica V.; Chennamadhavuni, Divya; Fandrick, Daniel R.; Haddad, Nizar; Grinberg, Nelu; Kurouski, Dimitry; Lee, Heewon; Song, Jinhua J.; Yee, Nathan K.; Mattson, Anita E.; Senanayake, Chris H. 分享 收藏
An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3′-F2-BINOL Zhang, Yongda; Wu, Jiang-Ping; Li, Guisheng; Fandrick, Keith R.; Gao, Joe; Tan, Zhulin; Johnson, Joe; Li, Wenjie; Sanyal, Sanjit; Wang, Jun; Sun, Xiufeng; Lorenz, Jon C.; Rodriguez, Sonia; Reeves, Jonathan T.; Grinberg, Nelu; Lee, Heewon; Yee, Nathan; Lu, Bruce Z.; Senanayake, Chris H. 分享 收藏
Ligand-Accelerated Stereoretentive Suzuki-Miyaura Coupling of Unprotected 3,3′-Dibromo-BINOL Qu, Bo; Haddad, Nizar; Rodriguez, Sonia; Sieber, Joshua D.; Desrosiers, Jean-Nicolas; Patel, Nitinchandra D.; Zhang, Yongda; Grinberg, Nelu; Lee, Heewon; Ma, Shengli; Ries, Uwe Joerg; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
Nickel-catalyzed C-3 direct arylation of pyridinium ions for the synthesis of 1-azafluorenes Desrosiers, Jean-Nicolas; Wei, Xudong; Gutierrez, Osvaldo; Savoie, Jolaine; Qu, Bo; Zeng, Xingzhong; Lee, Heewon; Grinberg, Nelu; Haddad, Nizar; Yee, Nathan K.; Roschangar, Frank; Song, Jinhua J.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏
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