Edward J. J. Grabowski - Publications, H-index & Citations

Edward J. J. Grabowski

merck & company

50H指数

258论文数

8.1K被引数

收录论文 53

发表时间

Highly Efficient Asymmetric Synthesis of Sitagliptin (vol 131, pg 8798, 2009)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-07-24

PREAI

Hansen, Karl B.; Hsiao, Yi; Xu, Feng; Rivera, Nelo; Clausen, Andrew; Kubryk, Michele; Krska, Shane; Rosner, Thorsten; Simmons, Bryon; Balsells, Jaume; Ikemoto, Nori; Sun, Yongkui; Spindler, Felix; Malan, Christophe; Grabowski, Edward J. J.; Armstrong, Joseph D., III

Highly Efficient Asymmetric Synthesis of Sitagliptin

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2009-06-09

255

PREAI

Hansen, Karl B.; Yi Hsiao; Xu, Feng; Rivera, Nelo; Clausen, Andrew; Kubryk, Michele; Krska, Shane; Rosner, Thorsten; Simmons, Bryon; Balsells, Jaume; Ikemoto, Nori; Sun, Yongkui; Spindler, Felix; Malan, Christophe; Grabowski, Edward J. J.; Armstrong, Joseph D., III

Practical, Highly Convergent, Asymmetric Synthesis of a Selective PPARγ Modulator

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2009-03-09

PREAI

Maligres, Peter E.; Humphrey, Guy R.; Marcoux, Jean-Francois; Hillier, Michael C.; Zhao, Dalian; Krska, Shane; Grabowski, Edward J. J.

Stereoselective formation of carbon-carbon bonds via SN2-displacement:: Synthesis of substituted cycloalkyl[b]indoles

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2005-09-20

PREAI

Hillier, MC; Marcoux, JF; Zhao, DL; Grabowski, EJJ; McKeown, AE; Tillyer, RD

First generation process for the preparation of the DPP-IV inhibitor sitagliptin 制备dpp-iv抑制剂西格列汀的第一代工艺

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2005-08-31

180

PREAI

Hansen, KB; Balsells, J; Dreher, S; Hsiao, Y; Kubryk, M; Palucki, M; Rivera, N; Steinhuebel, D; Armstrong, JD; Askin, D; Grabowski, EJJ

Asymmetric hydrogenation of N-sulfonylated-α-dehydroamino acids: Toward the synthesis of an anthrax lethal factor inhibitor

ORGANIC LETTERS

IF5

2005-07-14

PREAI

Shultz, CS; Dreher, SD; Ikemoto, N; Williams, JM; Grabowski, EJJ; Krska, SW; Sun, Y; Dormer, PG; DiMichele, L

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2005-03-16

PREAI

O'Shea, PD; Chen, CY; Chen, WR; Dagneau, P; Frey, LF; Grabowski, EJJ; Marcantonio, KM; Reamer, RA; Tan, LS; Tillyer, RD; Roy, A; Wang, X; Zhao, DL

Asymmetric synthesis of a prostaglandin D2 receptor antagonist

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2004-12-01

PREAI

Campos, KR; Journet, M; Lee, S; Grabowski, EJJ; Tillyer, RD

Mechanistic evidence for an α-oxoketene pathway in the formation of β-ketoamides/esters via Meldrum's acid adducts

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2004-09-16

PREAI

Xu, F; Armstrong, JD; Zhou, GX; Simmons, B; Hughes, D; Ge, ZH; Grabowski, EJJ

Practical synthesis of a potent hepatitis C virus RNA replication inhibitor

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2004-08-13

PREAI

Bio, MM; Xu, F; Waters, M; Williams, JM; Savary, KA; Cowden, CJ; Yang, CH; Buck, E; Song, ZGJ; Tschaen, DM; Volante, RP; Reamer, RA; Grabowski, EJJ

Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2004-07-21

252

PREAI

Hsiao, Y; Rivera, NR; Rosner, T; Krska, SW; Njolito, E; Wang, F; Sun, YK; Armstrong, JD; Grabowski, EJJ; Tillyer, RD; Spindler, F; Malan, C

Highly diastereoselective heterogeneously catalyzed hydrogenation of enamines for the synthesis of chiral β-amino acid derivatives

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2004-02-19

PREAI

Ikemoto, N; Tellers, DM; Dreher, SD; Liu, JC; Huang, A; Rivera, NR; Njolito, E; Hsiao, Y; McWilliams, JC; Williams, JM; Armstrong, JD; Sun, YK; Mathre, DJ; Grabowski, EJJ; Tillyer, RD

Synthesis of substituted imidazoles via organocatalysis

ORGANIC LETTERS

IF5

2004-02-11

184

PREAI

Frantz, DE; Morency, L; Soheili, A; Murry, JA; Grabowski, EJJ; Tillyer, RD

Stereoselective carbon-carbon bond formation via the mitsunobu displacement of chiral secondary benzylic alcohols

ORGANIC LETTERS

IF5

2004-01-16

PREAI

Hillier, MC; Desrosiers, JN; Marcoux, JF; Grabowski, EJJ

Practical asymmetric synthesis of a potent cathepsin K inhibitor. Efficient palladium removal following Suzuki coupling

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2003-03-04

PREAI

Chen, CY; Dagneau, P; Grabowski, EJJ; Oballa, R; O'Shea, P; Prasit, P; Robichaud, J; Tillyer, R; Wang, X

Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2002-08-28

PREAI

Zhao, MM; McNamara, JM; Ho, GJ; Emerson, KM; Song, ZGJ; Tschaen, DM; Brands, KMJ; Dolling, UH; Grabowski, EJJ; Reider, PJ; Cottrell, IF; Ashwood, MS; Bishop, BC

AN ENANTIOSELECTIVE SYNTHESIS OF THE TOPICALLY-ACTIVE CARBONIC-ANHYDRASE INHIBITOR MK-0507 - 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6-METHYL-4H-THIENO[2,3-B]THIOPYRAN-2-SULFONAMIDE 7,7-DIOXIDE HYDROCHLORIDE

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2002-05-01

PREAI

BLACKLOCK, TJ; SOHAR, P; BUTCHER, JW; LAMANEC, T; GRABOWSKI, EJJ

CARBODIIMIDE-MEDIATED AMIDE FORMATION IN A 2-PHASE SYSTEM - A HIGH-YIELD AND LOW-RACEMIZATION PROCEDURE FOR PEPTIDE-SYNTHESIS

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2002-05-01

PREAI

HO, GJ; EMERSON, KM; MATHRE, DJ; SHUMAN, RF; GRABOWSKI, EJJ