未登录 Enhancing SIRT1 Gene Expression Using Small Activating RNAs: A Novel Approach for Reversing Metabolic Syndrome Andrikakou, Pinelopi; Reebye, Vikash; Vasconcelos, Daniel; Yoon, Sorah; Voutila, Jon; George, Andrew J. T.; Swiderski, Piotr; Habib, Robert; Catley, Matthew; Blakey, David; Habib, Nagy A.; Rossi, John J.; Huang, Kai-Wen 分享 收藏
PSMA-PET Detection of Unusual Metastases in Castrate-Sensitive Prostate Carcinoma Harris, Nathanial; Tan, Mun Yee; Ng, Michael; Blakey, David; Guerrieri, Mario; Joon, Daryl Lim; Lau, Eddie; Foroudi, Farshad; Armstrong, Alexander; Chao, Michael 分享 收藏
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-a, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial Sarker, Debashis; Plummer, Ruth; Meyer, Tim; Sodergren, Mikael H.; Basu, Bristi; Chee, Cheng Ean; Huang, Kai-Wen; Palmer, Daniel H.; Ting, Yuk; Evans, T. R. Jeff; Spalding, Duncan R. C.; Pai, Madhava; Sharma, Rohini; Pinato, David J.; Spicer, James; Hunter, Sarah; Kwatra, Vineet; Nicholls, Joanna P.; Collin, David; Nutbrown, Robert; Glenny, Helen; Fairbairn, Sonia; Reebye, Vikash; Voutila, Jon; Dorman, Stephanie; Andrikakou, Pinelopi; Lloyd, Peter; Felstead, Steve; Vasara, Jenni; Habib, Robert; Wood, Chris; Saetrom, Pal; Huber, Hans E.; Blakey, David C.; Rossi, John J.; Habib, Nagy 分享 收藏
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Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice Zhou, Jiehua; Li, Haitang; Xia, Xin; Herrera, Alberto; Pollock, Nicolette; Reebye, Vikash; Sodergren, Mikael H.; Dorman, Stephanie; Littman, Bruce H.; Doogan, Declan; Huang, Kai-Wen; Habib, Robert; Blakey, David; Habib, Nagy A.; Rossi, John J. 分享 收藏
Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer Reebye, Vikash; Huang, Kai-Wen; Lin, Vivian; Jarvis, Sheba; Cutilas, Pedro; Dorman, Stephanie; Ciriello, Simona; Andrikakou, Pinelopi; Voutila, Jon; Saetrom, Pal; Mintz, Paul J.; Reccia, Isabella; Rossi, John J.; Huber, Hans; Habib, Robert; Kostomitsopoulos, Nikos; Blakey, David C.; Habib, Nagy A. 分享 收藏
Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer Voutila, Jon; Reebye, Vikash; Roberts, Thomas C.; Protopapa, Pantelitsa; Andrikakou, Pinelopi; Blakey, David C.; Habib, Robert; Huber, Hans; Saetrom, Pal; Rossi, John J.; Habib, Nagy A. 分享 收藏
MTL-CEBPA activates the transcription factor CEBPalpha leading to inhibition of hepatocellular cancer growth Habib, Nagy; Reebye, Vikash; Zhao, Xiaoyang; Voutila, Jon; Habib, Robert; Saetrom, Pal; Huber, Hans; Huang, Kai-Wen; Rossi, John J.; Blakey, David C. 分享 收藏
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS Ross, Sarah J.; Revenko, Alexey S.; Hanson, Lyndsey L.; Ellston, Rebecca; Staniszewska, Anna; Whalley, Nicky; Pandey, Sanjay K.; Revill, Mitchell; Rooney, Claire; Buckett, Linda K.; Klein, Stephanie K.; Hudson, Kevin; Monia, Brett P.; Zinda, Michael; Blakey, David C.; Lyne, Paul D.; Macleod, A. Robert 分享 收藏
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer Hong, David; Kurzrock, Razelle; Kim, Youngsoo; Woessner, Richard; Younes, Anas; Nemunaitis, John; Fowler, Nathan; Zhou, Tianyuan; Schmidt, Joanna; Jo, Minji; Lee, Samantha J.; Yamashita, Mason; Hughes, Steven G.; Fayad, Luis; Piha-Paul, Sarina; Nadella, Murali V. P.; Mohseni, Morvarid; Lawson, Deborah; Reimer, Corinne; Blakey, David C.; Xiao, Xiaokun; Hsu, Jeff; Revenko, Alexey; Monia, Brett P.; MacLeod, A. Robert 分享 收藏
Preclinical pharmacology and clinical efficacy of AZD9150 (ISIS-STAT3Rx), a potent next-generation antisense oligonucleotide inhibitor of STAT3 Hong, David; Kim, Youngsoo; Younes, Anas; Nemunaitis, John; Fowler, Nathan; Hsu, Jeff; Zhou, Tianyuan; Fayad, Luis; Zhang, Nancy; Piha-Paul, Sarina; Woessner, Richard; Nadella, Murali V.; Lawson, Deborah; Reimer, Corinne; Jo, Minji; Schmidt, Joanna; Xiao, Xiaokun; Greenlee, Sarah; Hung, Gene; Yamashita, Mason; Blakey, David C.; Monia, Brett P.; Macleod, A. Robert; Kurzrock, Razelle 分享 收藏
Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling Michaud, Neil R.; Wang, Youzhen; McEachern, Kristen A.; Jordan, Jerold J.; Mazzola, Anne Marie; Hernandez, Axel; Jalla, Sanjoo; Chesebrough, Jon W.; Hynes, Mark J.; Belmonte, Matthew A.; Wang, Lidong; Kang, Jaspal S.; Jovanovic, Jelena; Laing, Naomi; Jenkins, David W.; Hurt, Elaine; Liang, Meina; Frantz, Christopher; Hollingsworth, Robert E.; Simeone, Diane M.; Blakey, David C.; Bedian, Vahe 分享 收藏
Inhibition of Platelet-Derived Growth Factor Receptor a by MEDI-575 Reduces Tumor Growth and Stromal Fibroblast Content in a Model of Non-Small Cell Lung Cancers Laing, Naomi; McDermott, Brenda; Wen, Shenghua; Yang, David; Lawson, Deborah; Collins, Mike; Reimer, Corinne; Hall, Peter A.; Andersen, Harriet; Snaith, Michael; Wang, Xin; Bedian, Vahe; Cao, Zhu A.; Blakey, David 分享 收藏
Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology Prabhakar, Uma; Maeda, Hiroshi; Jain, Rakesh K.; Sevick-Muraca, Eva M.; Zamboni, William; Farokhzad, Omid C.; Barry, Simon T.; Gabizon, Alberto; Grodzinski, Piotr; Blakey, David C. 分享 收藏
MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo Jenkins, David W.; Ross, Sarah; Veldman-Jones, Margaret; Foltz, Ian N.; Clavette, Brandon C.; Manchulenko, Kathy; Eberlein, Cath; Kendrew, Jane; Petteruti, Philip; Cho, Song; Damschroder, Melissa; Peng, Li; Baker, Dawn; Smith, Neil R.; Weir, Hazel M.; Blakey, David C.; Bedian, Vahe; Barry, Simon T. 分享 收藏
An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding Kendrew, Jane; Eberlein, Cath; Hedberg, Brad; McDaid, Karen; Smith, Neil R.; Weir, Hazel M.; Wedge, Stephen R.; Blakey, David C.; Foltz, Ian; Zhou, Joe; Kang, Jaspal S.; Barry, Simon T. 分享 收藏
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth Gao, Jin; Chesebrough, Jon W.; Cartlidge, Susan A.; Ricketts, Sally-Ann; Incognito, Leonard; Veldman-Jones, Margaret; Blakey, David C.; Tabrizi, Mohammad; Jallal, Bahija; Trail, Pamela A.; Coats, Steven; Bosslet, Klaus; Chang, Yong S. 分享 收藏
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