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APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model APOE缺陷抑制了由淀粉样蛋白介导的(A)tau病理(T)和神经退行性变(N),阻止了在预临床模型中ATN病理的进展。 Vanherle, Sarah; Janssen, Art; de Rave, Manuel Gutierrez; Janssen, Bieke; Lodder, Chritica; Lucena, Pablo Botella; Kessels, Sofie; Hardy, Jana; Vandeput, Eline; Wang, Yanyan; Stancu, Ilie-Cosmin; Segal, Andrei; Kleinewietfeld, Markus; Voets, Thomas; Brone, Bert; Poovathingal, Suresh; Alpizar, Yeranddy A.; Dewachter, Ilse 分享 收藏
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Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models Basheer, Neha; Buee, Luc; Brion, Jean-Pierre; Smolek, Tomas; Muhammadi, Muhammad Khalid; Hritz, Jozef; Hromadka, Tomas; Dewachter, Ilse; Wegmann, Susanne; Landrieu, Isabelle; Novak, Petr; Mudher, Amritpal; Zilka, Norbert 分享 收藏
Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review 用于痴呆诊断和预后神经影像学的人工智能: 系统评价 Borchert, Robin; Azevedo, Tiago; Badhwar, AmanPreet; Bernal, Jose; Betts, Matthew; Bruffaerts, Rose C.; Burkhart, Michael; Dewachter, Ilse M.; Gellersen, Helena; Low, Audrey; Lourida, Ilianna; Machado, Luiza R.; Madan, Christopher; Malpetti, Maura; Mejia, Jhony; Michopoulou, Sofia; Munoz-Neira, Carlos; Pepys, Jack; Peres, Marion; Phillips, Veronica; Ramanan, Siddharth; Tamburin, Stefano M.; Tantiangco, Hanz; Thakur, Lokendra; Tomassini, Alessandro; Vipin, Ashwati; Tang, Eugene; Newby, Danielle; Ranson, Janice M.; Llewellyn, David J.; Veldsman, Michele; Rittman, Timothy 分享 收藏
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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia Lodder, Chritica; Scheyltjens, Isabelle; Stancu, Ilie Cosmin; Botella Lucena, Pablo; Gutierrez de Rave, Manuel; Vanherle, Sarah; Vanmierlo, Tim; Cremers, Niels; Vanrusselt, Hannah; Brone, Bert; Hanseeuw, Bernard; Octave, Jean-Noel; Bottelbergs, Astrid; Movahedi, Kiavash; Dewachter, Ilse 分享 收藏
Molecular understanding of label-free second harmonic imaging of microtubules 微管的无标记二次谐波成像的分子理解 Van Steenbergen, V.; Boesmans, W.; Li, Z.; de Coene, Y.; Vints, K.; Baatsen, P.; Dewachter, I; Ameloot, M.; Clays, K.; Vanden Berghe, P. 分享 收藏
DIETARY SARGASSUM FUSIFORME IMPROVES MEMORY AND REDUCES AMYLOID PLAQUE LOAD IN AN ALZHEIMER'S DISEASE MOUSE MODEL Mulder, M.; Bogie, J.; Hoeks, C.; Schepers, M.; Tuabe, A.; Leijten, F.; Chintapakorn, Y.; Struik, D.; Liu, H. B.; Hellings, N.; Martinez-Martinez, P.; Jonker, J.; Dewachter, I.; Walter, J.; Hendriks, J.; Groen, A.; Staels, B.; Lutjohann, D.; Vanmierlo, T. 分享 收藏
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model Bogie, Jeroen; Hoeks, Cindy; Schepers, Melissa; Tiane, Assia; Cuypers, Ann; Leijten, Frank; Chintapakorn, Yupyn; Suttiyut, Thiti; Pornpakakul, Surachai; Struik, Dicky; Kerksiek, Anja; Liu, Hong-Bing; Hellings, Niels; Martinez-Martinez, Pilar; Jonker, Johan W.; Dewachter, Ilse; Sijbrands, Eric; Walter, Jochen; Hendriks, Jerome; Groen, Albert; Staels, Bart; Luetjohann, Dieter; Vanmierlo, Tim; Mulder, Monique 分享 收藏
Sex-regulated gene dosage effect of PPARα on synaptic plasticity Pierrot, Nathalie; Ris, Laurence; Stancu, Ilie-Cosmin; Doshina, Anna; Ribeiro, Floriane; Tyteca, Donatienne; Bauge, Eric; Lalloyer, Fanny; Malong, Liza; Schakman, Olivier; Leroy, Karelle; Kienlen-Campard, Pascal; Gailly, Philippe; Brion, Jean-Pierre; Dewachter, Ilse; Staels, Bart; Octave, Jean-Noel 分享 收藏
Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo 聚集的Tau激活NLRP3-ASC炎性体,加剧体内外源接种和非外源接种的Tau病理 Stancu, Ilie-Cosmin; Cremers, Niels; Vanrusselt, Hannah; Couturier, Julien; Vanoosthuyse, Alexandre; Kessels, Sofie; Lodder, Chritica; Brone, Bert; Huaux, Francois; Octave, Jean-Noel; Terwel, Dick; Dewachter, Ilse 分享 收藏
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau McInnes, Joseph; Wierda, Keimpe; Snellinx, An; Bounti, Laura; Wang, Yu-Chun; Stancu, Ilie-Cosmin; Apostolo, Nuno; Gevaert, Kris; Dewachter, Ilse; Spires-Jones, Tara L.; De Strooper, Bart; De Wit, Joris; Zhou, Lujia; Verstreken, Patrik 分享 收藏
What is the evidence that tau pathology spreads through prion-like propagation? Mudher, Amrit; Colin, Morvane; Dujardin, Simon; Medina, Miguel; Dewachter, Ilse; Naini, Seyedeh Maryam Alavi; Mandelkow, Eva-Maria; Mandelkow, Eckhard; Buee, Luc; Goedert, Michel; Brion, Jean-Pierre 分享 收藏
Presenilin 2-Dependent Maintenance of Mitochondria! Oxidative Capacity and Morphology Contino, Sabrina; Porporato, Paolo E.; Bird, Matthew; Marinangeli, Claudia; Opsomer, Remi; Sonveaux, Pierre; Bontemps, Francoise; Dewachter, Ilse; Octave, Jean-Noel; Bertrand, Luc; Stanga, Serena; Kienlen-Campard, Pascal 分享 收藏
Tau association with synaptic vesicles causes presynaptic dysfunction Zhou, Lujia; McInnes, Joseph; Wierda, Keimpe; Holt, Matthew; Herrmann, Abigail G.; Jackson, Rosemary J.; Wang, Yu-Chun; Swerts, Jef; Beyens, Jelle; Miskiewicz, Katarzyna; Vilain, Sven; Dewachter, Ilse; Moechars, Diederik; De Strooper, Bart; Spires-Jones, Tara L.; De Wit, Joris; Verstreken, Patrik 分享 收藏