.png){kind=icon}
返回
Tau association with synaptic vesicles causes presynaptic dysfunction
.png){kind=icon}
OA
AI
DOI：10.1038/ncomms15295.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
AbstractTau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic dysfunction prior to Tau aggregate formation, but the underlying mechanism is unclear. Here we show that pathogenic Tau binds to synaptic vesicles via its N-terminal domain and interferes with presynaptic functions, including synaptic vesicle mobility and release rate, lowering neurotransmission in fly and rat neurons. Pathological Tau mutants lacking the vesicle binding domain still localize to the presynaptic compartment but do not impair synaptic function in fly neurons. Moreover, an exogenously applied membrane-permeable peptide that competes for Tau-vesicle binding suppresses Tau-induced synaptic toxicity in rat neurons. Our work uncovers a presynaptic role of Tau that may be part of the early pathology in various Tauopathies and could be exploited therapeutically.
Keyword:
EARLY ALZHEIMERS-DISEASE
AMYLOID-BETA
TRANSGENIC MICE
MOUSE MODEL
NEURODEGENERATION
DROSOPHILA
ACTIVATION
TAUOPATHY
PATHOLOGY
NEURONS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
机构
引用论文
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease突触蛋白表达的改变发生在阿尔茨海默病进展的早期.png)
NEUROLOGYOAAI
NEUROLOGYIF8.5
OAAI分享收藏Mobility of synaptic vesicles in different pools in resting and stimulated frog motor nerve terminalsNEURON
OAAI
NEURONIF15
OAAI分享收藏Extensive p-Tau Pathology and SDS-Stable p-Tau Oligomers in Alzheimer's Cortical SynapsesBRAIN PATHOLOGYOAAI
BRAIN PATHOLOGYIF6.2
OAAI分享收藏Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutationsOAAI
OAAI分享收藏
查看更多内容