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Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities Brca1功能的遗传分离揭示了依赖于突变的pol θ 漏洞 Krais, John J.; Glass, David J.; Chudoba, Ilse; Wang, Yifan; Feng, Wanjuan; Simpson, Dennis; Patel, Pooja; Liu, Zemin; Neumann-Domer, Ryan; Betsch, Robert G.; Bernhardy, Andrea J.; Bradbury, Alice M.; Conger, Jason; Yueh, Wei-Ting; Nacson, Joseph; Pomerantz, Richard T.; Gupta, Gaorav P.; Testa, Joseph R.; Johnson, Neil 分享 收藏
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BRCA1 Mutational Complementation Induces Synthetic Viability Nacson, Joseph; Di Marcantonio, Daniela; Wang, Yifan; Bernhardy, Andrea J.; Clausen, Emma; Hua, Xiang; Cai, Kathy Q.; Martinez, Esteban; Feng, Wanjuan; Callen, Elsa; Wu, Wei; Gupta, Gaorav P.; Testa, Joseph R.; Nussenzweig, Andre; Sykes, Stephen M.; Johnsons, Neil 分享 收藏
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations Park, Pyoung Hwa; Yamamoto, Tomomi M.; Li, Hua; Alcivar, Allen L.; Xia, Bing; Wang, Yifan; Bernhardy, Andrea J.; Turner, Kristen M.; Kossenkov, Andrew V.; Watson, Zachary L.; Behbakht, Kian; Casadei, Silvia; Swisher, Elizabeth M.; Mischel, Paul S.; Johnson, Neil; Bitler, Benjamin G. 分享 收藏
BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance Wang, Yifan; Bernhardy, Andrea J.; Nacson, Joseph; Krais, John J.; Tan, Yin-Fei; Nicolas, Emmanuelle; Radke, Marc R.; Handorf, Elizabeth; Llop-Guevara, Alba; Balmana, Judith; Swisher, Elizabeth M.; Serra, Violeta; Peri, Suraj; Johnson, Neil 分享 收藏
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance (vol 24, 3513, 2018) Nacson, Joseph; Krais, John J.; Bernhardy, Andrea J.; Clausen, Emma; Feng, Wanjuan; Wang, Yifan; Nicolas, Emmanuelle; Cai, Kathy Q.; Tricarico, Rossella; Hua, Xiang; DiMarcantonio, Daniela; Martinez, Esteban; Zong, Dali; Handorf, Elizabeth A.; Bellacosa, Alfonso; Testa, Joseph R.; Nussenzweig, Andre; Gupta, Gaorav P.; Sykes, Stephen M.; Johnson, Neil 分享 收藏
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance Nacson, Joseph; Krais, John J.; Bernhardy, Andrea J.; Clausen, Emma; Feng, Wanjuan; Wang, Yifan; Nicolas, Emmanuelle; Cai, Kathy Q.; Tricarico, Rossella; Hua, Xiang; DiMarcantonio, Daniela; Martinez, Esteban; Zong, Dali; Handorf, Elizabeth A.; Bellacosa, Alfonso; Testa, Joseph R.; Nussenzweig, Andre; Gupta, Gaorav P.; Sykes, Stephen M.; Johnson, Neil 分享 收藏
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara; Langer, Samantha; Siciliano, Micheal; Nieborowska-Skorska, Margaret; Hanamshet, Kritika; Belyaeva, Elizaveta A.; Bernhardy, Andrea J.; Lee, Jaewong; Moore, Morgan; Zhao, Huaqing; Valent, Peter; Matlawska-Wasowska, Ksenia; Muschen, Markus; Bhatia, Smita; Bhatia, Ravi; Johnson, Neil; Wasik, Mariusz A.; Mazin, Alexander, V; Skorski, Tomasz 分享 收藏
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CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer Johnson, Shawn F.; Cruz, Cristina; Greifenberg, Ann Katrin; Dust, Sofia; Stover, Daniel G.; Chi, David; Primack, Benjamin; Cao, Shiliang; Bernhardy, Andrea J.; Coulson, Rhiannon; Lazaro, Jean-Bernard; Kochupurakkal, Bose; Sun, Heather; Unitt, Christine; Moreau, Lisa A.; Sarosiek, Kristopher A.; Scaltriti, Maurizio; Juric, Dejan; Baselga, Jose; Richardson, Andrea L.; Rodig, Scott J.; D'Andrea, Alan D.; Balmana, Judith; Johnson, Neil; Geyer, Matthias; Serra, Violeta; Lim, Elgene; Shapiro, Geoffrey I. 分享 收藏
RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance Wang, Yifan; Krais, John J.; Bernhardy, Andrea J.; Nicolas, Emmanuelle; Cai, Kathy Q.; Harrell, Maria I.; Kim, Hyoung H.; George, Erin; Swisher, Elizabeth M.; Simpkins, Fiona; Johnson, Neil 分享 收藏
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin Wang, Yifan; Bernhardy, Andrea J.; Cruz, Cristina; Krais, John J.; Nacson, Joseph; Nicolas, Emmanuelle; Peri, Suraj; van der Gulden, Hanneke; van der Heijden, Ingrid; O'Brien, Shane W.; Zhang, Yong; Harrell, Maribel I.; Johnson, Shawn F.; Candido Dos Reis, Francisco J.; Pharoah, Paul D. P.; Karlan, Beth; Gourley, Charlie; Lambrechts, Diether; Chenevix-Trench, Georgia; Olsson, Hakan; Benitez, Javier J.; Greene, Mark H.; Gore, Martin; Nussbaum, Robert; Sadetzki, Siegal; Gayther, Simon A.; Kjaer, Susanne K.; D'Andrea, Alan D.; Shapiro, Geoffrey I.; Wiest, David L.; Connolly, Denise C.; Daly, Mary B.; Swisher, Elizabeth M.; Bouwman, Peter; Jonkers, Jos; Balmana, Judith; Serra, Violeta; Johnson, Neil 分享 收藏
BRCA1 N-terminal-deficient proteins provide PARP inhibitor and platinum resistance Wang, Yifan; Bernhardy, Andrea; Nicolas, Emmanuelle; Winters, Ryan; Cai, Kathy; Duncan, Kelly; Duncan, James; Harrell, Maria; Swisher, Elizabeth; Johnson, Neil 分享 收藏
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Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance Johnson, Neil; Johnson, Shawn F.; Yao, Wei; Li, Yu-Chen; Choi, Young-Eun; Bernhardy, Andrea J.; Wang, Yifan; Capelletti, Marzia; Sarosiek, Kristopher A.; Moreau, Lisa A.; Chowdhury, Dipanjan; Wickramanayake, Anneka; Harrell, Maria I.; Liu, Joyce F.; D'Andrea, Alan D.; Miron, Alexander; Swisher, Elizabeth M.; Shapiro, Geoffrey I. 分享 收藏
The APOL1 Genotype of African American Kidney Transplant Recipients Does Not Impact 5-Year Allograft Survival 非裔美国人肾移植受者的APOL1基因型不影响同种异体移植的5年生存率 Lee, B. T.; Kumar, V.; Williams, T. A.; Abdi, R.; Bernhardy, A.; Dyer, C.; Conte, S.; Genovese, G.; Ross, M. D.; Friedman, D. J.; Gaston, R.; Milford, E.; Pollak, M. R.; Chandraker, A. 分享 收藏
Genetic Variation in APOL1 Associates with Younger Age at Hemodialysis Initiation Kanji, Zahra; Powe, Camille E.; Wenger, Julia B.; Huang, Chunmei; Ankers, Elizabeth; Sullivan, Dorothy A.; Collerone, Gina; Powe, Neil R.; Tonelli, Marcello; Bhan, Ishir; Bernhardy, Andrea J.; DiBartolo, Salvatore; Friedman, David; Genovese, Giulio; Pollak, Martin R.; Thadhani, Ravi 分享 收藏
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