未登录 Parallel Buprenorphine phMRI Responses in Conscious Rodents and Healthy Human Subjects 有意识的啮齿动物和健康人类受试者的平行丁丙诺啡phMRI反应 Becerra, Lino; Upadhyay, Jaymin; Chang, Pei-Ching; Bishop, James; Anderson, Julie; Baumgartner, Richard; Schwarz, Adam J.; Coimbra, Alexandre; Wallin, Diana; Nutile, Lauren; George, Edward; Maier, Gary; Sunkaraneni, Soujanya; Iyengar, Smriti; Evelhoch, Jeffrey L.; Bleakman, David; Hargreaves, Richard; Borsook, David 分享 收藏
Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain Borsook, David; Upadhyay, Jaymin; Klimas, Michael; Schwarz, Adam J.; Coimbra, Alexandre; Baumgartner, Richard; George, Edward; Potter, William Z.; Large, Thomas; Bleakman, David; Evelhoch, Jeffrey; Iyengar, Smriti; Becerra, Lino; Hargreaves, Richard J. 分享 收藏
Imaging Drugs with and without Clinical Analgesic Efficacy 具有和不具有临床镇痛效果的成像药物 Upadhyay, Jaymin; Anderson, Julie; Schwarz, Adam J.; Coimbra, Alexandre; Baumgartner, Richard; Pendse, G.; George, Edward; Nutile, Lauren; Wallin, Diana; Bishop, James; Neni, Saujanya; Maier, Gary; Iyengar, Smriti; Evelhoch, Jeffery L.; Bleakman, David; Hargreaves, Richard; Becerra, Lino; Borsook, David 分享 收藏
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices Schwarz, Adam J.; Becerra, Lino; Upadhyay, Jaymin; Anderson, Julie; Baumgartner, Richard; Coimbra, Alexander; Evelhoch, Jeff; Hargreaves, Richard; Robertson, Brigitte; Lyengar, Smriti; Tauscher, Johannes; Bleakman, David; Borsook, David 分享 收藏
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements Schwarz, Adam J.; Becerra, Lino; Upadhyay, Jaymin; Anderson, Julie; Baumgartner, Richard; Coimbra, Alexandre; Evelhoch, Jeff; Hargreaves, Richard; Robertson, Brigitte; Iyengar, Smriti; Tauscher, Johannes; Bleakman, David; Borsook, David 分享 收藏
Synthesis and pharmacological characterization of N3-substituted willardiine derivatives:: Role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists Dolman, Nigel P.; More, Julia C. A.; Alt, Andrew; Knauss, Jody L.; Pentikainen, Olli T.; Glasser, Carla R.; Bleakman, David; Mayer, Mark L.; Collingridge, Graham L.; Jane, David E. 分享 收藏
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Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo Weiss, Brianne; Alt, Andrew; Ogden, Ann Marie; Gates, Mary; Dieckman, Donna K.; Clemens-Smith, Amy; Ho, Ken H.; Jarvie, Keith; Rizkalla, Geihan; Wright, Rebecca A.; Calligaro, David O.; Schoepp, Darryle; Mattiuz, Edward L.; Stratford, Robert E.; Johnson, Bryan; Salhoff, Craig; Katofiasc, Mary; Phebus, Lee A.; Schenck, Kathryn; Cohen, Marlene; Filla, Sandra A.; Ornstein, Paul L.; Johnson, Kirk W.; Bleakman, David 分享 收藏
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Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors Dolman, NP; Troop, HM; More, JCA; Alt, A; Knauss, JL; Nistico, R; Jack, S; Morley, RM; Bortolotto, ZA; Roberts, PJ; Bleakman, D; Collingridge, GL; Jane, DE 分享 收藏
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain Dominguez, E; Iyengar, S; Shannon, HE; Bleakman, D; Alt, A; Arnold, BM; Bell, MG; Bleisch, TJ; Buckmaster, JL; Castano, AM; Del Prado, M; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AML; Simmons, RMA; Stack, DR; Stratford, RE; Winter, MA; Wu, ZP; Ornstein, PL 分享 收藏
LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine Sang, CN; Ramadan, NM; Wallihan, RG; Chappell, AS; Freitag, FG; Smith, TR; Silberstein, SD; Johnson, KW; Phebus, LA; Bleakman, D; Ornstein, PL; Arnold, B; Tepper, SJ; Vandenhende, F 分享 收藏
LY503430, a novel α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease Murray, TK; Whalley, K; Robinson, CS; Ward, MA; Hicks, CA; Lodge, D; Vandergriff, JL; Baumbarger, P; Siuda, E; Gates, M; Ogden, AM; Skolnick, P; Zimmerman, DM; Nisenbaum, ES; Bleakman, D; O'Neill, MJ 分享 收藏
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Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester:: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine Filla, SA; Winter, MA; Johnson, KW; Bleakman, D; Bell, MG; Bleisch, TJ; Castaño, AM; Clemens-Smith, A; del Prado, M; Dieckman, DK; Dominguez, E; Escribano, A; Ho, KH; Hudziak, KJ; Katofiasc, MA; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AML; Phebus, LA; Stack, DR; Stratford, RE; Ornstein, PL 分享 收藏
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[3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide:: A novel AMPA receptor potentiates and radioligand Zarrinmayeh, H; Bleakman, D; Gates, MR; Yu, H; Zimmerman, DM; Ornstein, PL; McKennon, T; Arnold, MB; Wheeler, WJ; Skolnick, P 分享 收藏
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