Brian D. Palmer - Publications, H-index & Citations

Brian D. Palmer

university of michigan system

51H指数

262论文数

8.4K被引数

收录论文 62

发表时间

Synthesis and Structure-Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines 3-苯基-n-(Pyridin-2-ylmethyl) 吡唑并 [1，5-a]Pyrimidin-7-Amines抗分枝杆菌活性的合成和构效关系

PHARMACEUTICALS

IF4.8

2022-09-08

OAAI

Sutherland, Hamish S.; Choi, Peter J.; Lu, Guo-Liang; Giddens, Anna C.; Tong, Amy S. T.; Franzblau, Scott G.; Cooper, Christopher B.; Palmer, Brian D.; Denny, William A.

Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

PHARMACEUTICALS

IF4.8

2022-08-31

OAAI

Tijono, Sofian M.; Palmer, Brian D.; Tomek, Petr; Flanagan, Jack U.; Henare, Kimiora; Gamage, Swarna; Braun, Lukas; Ching, Lai-Ming

Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis 新型结核分枝杆菌四氢萘酰胺类抑制剂的合成及构效关系

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-02-01

OAAI

Sutherland, Hamish S. S.; Lu, Guo-Liang; Tong, Amy S. T. G.; Conole, Daniel M.; Franzblau, Scott G. U.; Upton, Anna B.; Lotlikar, Manisha U. D.; Cooper, Christopher B. J.; Palmer, Brian D. A.; Choi, Peter J.; Denny, William A.

Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-06-01

PREAI

de Iudicibus, Rossella Capochiani; Tomek, Petr; Palmer, Brian D.; Tijono, Sofian M.; Flanagan, Jack U.; Ching, Lai-Ming

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis 四氢异喹啉类结核分枝杆菌抑制剂的合成及构效关系

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-11-01

OAAI

Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Sutherland, Hamish S.; Choi, Peter J.; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Denny, William A.; Palmer, Brian D.

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline 合成研究，以帮助阐明TBAJ-876-A毒性较小且更有效的Bedaquiline类似物的临床前候选药物的代谢

MOLECULES

IF4.6

2020-03-20

OAAI

Choi, Peter J.; Conole, Daniel; Sutherland, Hamish S.; Blaser, Adrian; Tong, Amy S. T.; Cooper, Christopher B.; Upton, Anna M.; Palmer, Brian D.; Denny, William A.

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-01-01

OAAI

Sutherland, Hamish S.; Tong, Amy S. T.; Choi, Peter J.; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha; Denny, William A.; Palmer, Brian D.

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

NATURE COMMUNICATIONS

IF15.7

2019-04-05

OAAI

Bashiri, Ghader; Antoney, James; Jirgis, Ehab N. M.; Shah, Mihir V.; Ney, Blair; Copp, Janine; Stuteley, Stephanie M.; Sreebhavan, Sreevalsan; Palmer, Brian; Middleditch, Martin; Tokuriki, Nobuhiko; Greening, Chris; Scott, Colin; Baker, Edward N.; Jackson, Colin J.

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline 结核药物bedaquiline的单元C吡啶基类似物的结构-活性关系

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-04-01

OAAI

Blaser, Adrian; Sutherland, Hamish S.; Tong, Amy S. T.; Choi, Peter J.; Conole, Daniel; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha; Denny, William A.; Palmer, Brian D.

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel 贝达喹啉的3，5-二烷氧基吡啶类似物是有效的抗结核药，对hERG通道的抑制作用最小

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-04-01

OAAI

Sutherland, Hamish S.; Tong, Amy S. T.; Choi, Peter J.; Blaser, Adrian; Conole, Daniel; Franzblau, Scott G.; Lotlikar, Manisha U.; Cooper, Christopher B.; Upton, Anna M.; Denny, William A.; Palmer, Brian D.

Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2018-09-01

PREAI

Kanamala, Manju; Palmer, Brian D.; Wilson, William R.; Wu, Zimei

PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation

PHARMACEUTICAL RESEARCH

IF4.3

2018-05-31

PREAI

Kanamala, Manju; Palmer, Brian D.; Ghandehari, Hamidreza; Wilson, William R.; Wu, Zimei

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-05-01

OAAI

Sutherland, Hamish S.; Tong, Amy S. T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2017-09-28

OAAI

Tong, Amy S. T.; Choi, Peter J.; Blaser, Adrian; Sutherland, Hamish S.; Tsang, Sophia K. Y.; Guillemont, Jerome; Motte, Magali; Cooper, Christopher B.; Andries, Koen; Van den Broeck, Walter; Franzblau, Scott G.; Upton, Anna M.; Denny, William A.; Palmer, Brian D.; Conole, Daniel

In vitro and in vivo models for evaluation of inhibitors of tryptophan dioxygenases

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Ching, Lai-Ming; Tomek, Petr; Palmer, Brian D.; Tijono, Sofian; Henare, Kimiora; Braun, Lukas M.

Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions 发现和评估免疫抑制酶吲哚胺2，3-双加氧酶1 (IDO1) 的抑制剂: 探索活性位点-抑制剂相互作用

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-01-01

PREAI

Tomek, Petr; Palmer, Brian D.; Flanagan, Jack U.; Sun, Chuanwen; Raven, Emma L.; Ching, Lai-Ming

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-08-22

PREAI

Smaill, Jeff B.; Gonzales, Andrea J.; Spicer, Julie A.; Lee, Helen; Reed, Jessica E.; Sexton, Karen; Althaus, Irene W.; Zhu, Tong; Black, Shannon L.; Blaser, Adrian; Denny, William A.; Ellis, Paul A.; Fakhoury, Stephen; Harvey, Patricia J.; Hook, Ken; McCarthy, Florence O. J.; Palmer, Brian D.; Rivault, Freddy; Schlosser, Kevin; Ellis, Teresa; Thompson, Andrew M.; Trachet, Erin; Winters, R. Thomas; Tecle, Haile; Bridges, Alexander

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

BIOMATERIALS

IF12.9

2016-04-01

816

PREAI

Kanamala, Manju; Wilson, William R.; Yang, Mimi; Palmer, Brian D.; Wu, Zimei

A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Ching, Lai-Ming; Palmer, Brian D.; Tomek, Petr; Flanagan, Jack U.; Henare, Kimiora

Synthesis and Structure-Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-midazo[2,1-b][1,3]oxazine (PA-824)抗结核药物 (6s)-2-硝基-6-{[4-(三氟甲氧基) 苄基] 氧基}-6，7-二氢-5h-咪唑并 [2，1-b][1,3] 恶嗪 (PA-824) 的合成和结构活性关系

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-03-27

PREAI

Palmer, Brian D.; Sutherland, Hamish S.; Blaser, Adrian; Kmentova, Ineta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.; Thompson, Andrew M.

研究方向