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Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors Shields, Jason D.; Aquila, Brian M.; Emmons, David; Finlay, M. Raymond V.; Gangl, Eric T.; Gu, Chungang; Mlynarski, Scott N.; Petersen, Jens; Pop-Damkov, Petar; Sha, Li; Simpson, Iain; Tavakoli, Siavash; Tentarelli, Sharon; Wang, Haixia; Ye, Qing; Zheng, XiaoLan 分享 收藏
Neuroprotective effects of ulinastatin on Escherichia coli meningitis rats through inhibiting PKCα phosphorylation and reducing zonula occludens-1 degradation Zheng, Xiaolan; Wang, Junsheng; Su, Huihong; Wu, Lingling; Zhang, Yan; Tang, Qianqian; Ban, Tingting; Xie, Kun; Wei, Chunmiao; Lin, Caimei 分享 收藏
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Photoredox Catalysis: 1,4-Conjugate Addition of N-Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of N-Substituted Acetic Acids Gingipalli, Lakshmaiah; Boerth, Jeffrey; Emmons, David; Grebe, Tyler; Hatoum-Mokdad, Holia; Peng, Bo; Sha, Li; Tentarelli, Sharon; Wang, Haixia; Wu, Ye; Zheng, XiaoLan; Edmondson, Scott; Gopalsamy, Ariamala 分享 收藏
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2-pyridylmethoxy) benzamide (AZD7254) Yang, Bin; Hird, Alexander W.; Bodnarchuk, Michael S.; Zheng, Xiaolan; Dakin, Les; Su, Qibin; Daly, Kevin; Godin, Robert; Hattersley, Maureen M.; Brassil, Patrick; Redmond, Sean; Russell, Daniel John; Janetka, James W. 分享 收藏
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Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia Tron, Adriana E.; Belmonte, Matthew A.; Adam, Ammar; Aquila, Brian M.; Boise, Lawrence H.; Chiarparin, Elisabetta; Cidado, Justin; Embrey, Kevin J.; Gangl, Eric; Gibbons, Francis D.; Gregory, Gareth P.; Hargreaves, David; Hendricks, J. Adam; Johannes, Jeffrey W.; Johnstone, Ricky W.; Kazmirski, Steven L.; Kettle, Jason G.; Lamb, Michelle L.; Matulis, Shannon M.; Nooka, Ajay K.; Packer, Martin J.; Peng, Bo; Rawlins, Philip B.; Robbins, Daniel W.; Schuller, Alwin G.; Su, Nancy; Yang, Wenzhan; Ye, Qing; Zheng, Xiaolan; Secrist, J. Paul; Clark, Edwin A.; Wilson, David M.; Fawell, Stephen E.; Hird, Alexander W. 分享 收藏
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors (vol 8, pg 239, 2017) Johannes, Jeffrey W.; Bates, Stephanie; Beigie, Carl; Belmonte, Matthew A.; Breen, John; Cao, Shenggen; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Dumelin, Christoph E.; Ferguson, Andrew D.; Habeshian, Sevan; Hargreaves, David; Joubran, Camil; Kazmirski, Steven; Keefe, Anthony D.; Lamb, Michelle L.; Lan, Haiye; Li, Yunxia; Ma, Hao; Mlynarski, Scott; Packer, Martin J.; Rawlins, Philip B.; Robbins, Daniel W.; Shen, Haidong; Sigel, Eric A.; Soutter, Holly H.; Su, Nancy; Troast, Dawn M.; Wang, Haiyun; Wickson, Kate F.; Wu, Chengyan; Zhang, Ying; Zhao, Qiuying; Zheng, Xiaolan; Hird, Alexander W. 分享 收藏
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AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers Hird, Alexander W.; Secrist, J. Paul; Adam, Ammar; Belmonte, Matthew A.; Gangl, Eric; Gibbons, Frank; Hargreaves, David; Johannes, Jeffrey W.; Kazmirski, Stephen L.; Kettle, Jason G.; Kurtz, Stephen E.; Lamb, Michelle L.; Packer, Martin J.; Peng, Bo; Stewart, Craig R.; Tyner, Jeffrey W.; Yang, Wenzhan; Ye, Qing; Zheng, XiaoLan; Clark, Edwin A. 分享 收藏
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors Johannes, Jeffrey W.; Bates, Stephanie; Beigie, Carl; Belmonte, Matthew A.; Breen, John; Cao, Shenggen; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Dumelin, Christoph E.; Ferguson, Andrew D.; Habeshian, Sevan; Hargreaves, David; Joubran, Camil; Kazmirski, Steven; Keefe, Anthony D.; Lamb, Michelle L.; Lan, Haiye; Li, Yunxia; Ma, Hao; Mlynarski, Scott; Packer, Martin J.; Rawlins, Philip B.; Robbins, Daniel W.; Shen, Haidong; Sigel, Eric A.; Soutter, Holly H.; Su, Nancy; Troast, Dawn M.; Wang, Haiyun; Wickson, Kate F.; Wu, Chengyan; Zhang, Ying; Zhao, Qiuying; Zheng, Xiaolan; Hird, Alexander W. 分享 收藏
Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors 底物竞争性SMYD2抑制剂的设计、合成及生物活性研究 Cowen, Scott D.; Russell, Daniel; Dakin, Leslie A.; Chen, Huawei; Larsen, Nicholas A.; Godin, Robert; Throner, Scott; Zheng, Xiaolan; Molina, Audrey; Wu, Jiaquan; Cheung, Tony; Howard, Tina; Garcia-Arenas, Renee; Keen, Nicholas; Pendleton, Christopher S.; Pietenpol, Jennifer A.; Ferguson, Andrew D. 分享 收藏
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Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology Johannes, Jeffrey W.; Almeida, Lynsie; Barlaam, Bernard; Boriack-Sjodin, P. Ann; Casella, Robert; Croft, Rosemary A.; Dishington, Allan P.; Gingipalli, Lakshmaiah; Gu, Chungang; Hawkins, Janet L.; Holmes, Jane L.; Howard, Tina; Huang, Jian; Ioannidis, Stephanos; Kazmirski, Steven; Lamb, Michelle L.; McGuire, Thomas M.; Moore, Jane E.; Ogg, Derek; Patel, Anil; Pike, Kurt G.; Pontz, Timothy; Robb, Graeme R.; Su, Nancy; Wang, Haiyun; Wu, Xiaoyun; Zhang, Hai-Jun; Zhang, Yue; Zheng, Xiaolan; Wang, Tao 分享 收藏
Efficacy and biomarker modulation by AZD1208, a novel, potent and selective pan-Pim kinase inhibitor, in models of acute myeloid leukemia Keeton, Erika; McEachern, Kristen; Alimzhanov, Marat; Wang, Suping; Cao, Yichen; Bao, Larry; Palakurthi, Sangeetha; Grondine, Michael; Chen, Yuching; DilIman, Keith; Chinnappan, Dharmaraj; Shen, Minhui; Dakin, Les; Zheng, Xiaolan; Lamb, Michelle; Wu, Ailan; Chen, Huawei; Lyne, Paul; Huszar, Dennis 分享 收藏
Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-metlyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-metlylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent Theoclitou, Maria-Elena; Aquila, Brian; Block, Michael H.; Brassil, Patrick J.; Castriotta, Lillian; Code, Erin; Collins, Michael P.; Davies, Audrey M.; Deegan, Tracy; Ezhuthachan, Jayachandran; Filla, Sandra; Freed, Ellen; Hu, Haiqing; Huszar, Dennis; Jayaraman, Muthusamy; Lawson, Deborah; Lewis, Paula M.; Nadella, Murali V. P.; Oza, Vibha; Padmanilayam, Maniyan; Pontz, Timothy; Ronco, Lucienne; Russell, Daniel; Whitston, David; Zheng, Xiaolan 分享 收藏
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