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Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair 雄激素受体抑制在前列腺癌模型中扩展了PARP抑制剂的活性，超越了BRCA突变和同源重组修复缺陷。 Illuzzi, Giuditta; Galbiati, Alessandro; Staniszewska, Anna D.; Hanson, Robert; Michaloglou, Chrysiis; Cooke, Sophie L.; Uznanska, Karolina; Bialecka, Maja; Solarczyk, Kamil; Dev, Harveer S.; Massie, Charlie E.; Albertella, Mark R.; Leo, Elisabetta; Forment, Josep, V; O'Connor, Mark J. 分享 收藏
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The DNA-PK inhibitor AZD7648 alone or combined with pegylated liposomal doxorubicin in patients with advanced cancer: results of a first-in-human Phase I/IIa study DNA-PK抑制剂AZD7648单药或联合聚乙二醇化脂质体多柔比星用于晚期癌症患者：一项首次人体I/IIa期研究的结果 Yap, Timothy A.; LoRusso, Patricia; Miller, Rowan E.; Kristeleit, Rebecca; Paulovich, Amanda G.; McMorn, Stephen; O'Connor, Lenka Oplustil; Lombardi, Benedetta; Marco-Casanova, Paola; Gangl, Eric T.; Patel, Bharat; O'Connor, Mark J.; Dean, Emma; Zviezdin, Roman; Plummer, Ruth 分享 收藏
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Understanding tumour growth variability in breast cancer xenograft models identifies PARP inhibition resistance biomarkers 理解乳腺癌异种移植模型中肿瘤生长变异可识别PARP抑制耐药生物标志物 Voulgarelis, D.; Forment, J. V.; Ropero, A. Herencia; Polychronopoulos, D.; Cohen-Setton, J.; Bender, A.; Serra, V.; O'Connor, M. J.; Yates, J. W. T.; Bulusu, K. C. 分享 收藏
ATR Inhibition and Replication Stress Converge on a BCL6-Mediated Reversal of the Dark Zone Signature in DLBCL ATR 抑制和复制应激汇聚于 DLBCL 中由 BCL6 介导的暗区特征的逆转 Chan, Allison; Anbuselvan, Akshaya; Jaynes, Patrick; Prabhu, Nayana; Ju, Yuan; Lee, Jane Jia Hui; Tan, Tze King; Goh, Jasmine; Foiani, Marco; Sanda, Takaomi; Tam, Wai Leong; O'Connor, Mark J.; Chow, Edward K.; Jeyasekharan, Anand Devaprasath D. 分享 收藏
Adavosertib in Combination with Olaparib in Patients with Refractory Solid Tumors: An Open-Label, Dose-Finding, and Dose-Expansion Phase Ib Trial Hamilton, Erika P.; Falchook, Gerald S.; Wang, Judy S.; Fu, Siqing; Oza, Amit M.; Imedio, Esteban Rodrigo; Kumar, Sanjeev; Ottesen, Lone; Mugundu, Ganesh M.; de Bruin, Elza C.; O'Connor, Mark J.; Jones, Suzanne F.; Spigel, David R.; Li, Bob T. 分享 收藏
Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma Davies, Nicholas; Francis, Tegan; Oldreive, Ceri; Azam, Maria; Wilson, Jordan; Byrd, Philip J.; Burley, Megan; Sharma-Oates, Archana; Keane, Peter; Alatawi, Sael; Higgs, Martin R.; Rudzki, Zbigniew; Ibrahim, Maha; Perry, Tracey; Agathanggelou, Angelo; Hewitt, Anne-Marie; Smith, Edward; Bonifer, Constanze; O'Connor, Mark; Forment, Josep V.; Murray, Paul G.; Fennell, Eanna; Kelly, Gemma; Chang, Catherine; Stewart, Grant S.; Stankovic, Tatjana; Kwok, Marwan; Taylor, Alexander Malcolm 分享 收藏
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer PARP和WEE1联合抑制触发BRCA1/2野生型三阴性乳腺癌的抗肿瘤免疫反应 Teo, Zhi Ling; O'Connor, Mark J.; Versaci, Stephanie; Clarke, Kylie A.; Brown, Emmaline R.; Percy, Luke W.; Kuykhoven, Keilly; Mintoff, Christopher P.; Savas, Peter; Virassamy, Balaji; Luen, Stephen J.; Byrne, Ann; Sant, Sneha; Lindeman, Geoffrey J.; Darcy, Phillip K.; Loi, Sherene 分享 收藏
Initial Experience With Intercostal Insertion of an Extravascular ICD Lead Compatible With Existing Pulse Generators Burke, Martin C.; Knops, Reinoud E.; Reddy, Vivek; Aasbo, Johan; Husby, Michael; Marcovecchio, Alan; O'Connor, Mark; Sanghera, Rick; Scheck, Don; Pepplinkhuizen, Shari; Ebner, Adrian 分享 收藏
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells MND1和PSMC3IP控制有丝分裂细胞的PARP抑制剂敏感性 Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S.; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep, V; O'Connor, Mark J.; Davies, Barry R.; van Vugt, Marcel A. T. M.; Krastev, Dragomir B.; Pettitt, Stephen J.; Tutt, Andrew N. J.; Rottenberg, Sven; Lord, Christopher J. 分享 收藏
PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors PARP抑制是BRCA缺陷肿瘤中抗肿瘤免疫反应的调节剂 Staniszewska, Anna D.; Armenia, Joshua; King, Matthew; Michaloglou, Chrysiis; Reddy, Avinash; Singh, Maneesh; San Martin, Maryann; Prickett, Laura; Wilson, Zena; Proia, Theresa; Russell, Deanna; Thomas, Morgan; Delpuech, Oona; O'Connor, Mark J.; Leo, Elisabetta; Angell, Helen; Valge-Archer, Viia 分享 收藏
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib ATR抑制剂AZD6738 (Ceralasertib) 作为单一疗法以及与化疗和PARP抑制剂Olaparib联合使用具有抗肿瘤活性 Wilson, Zena; Odedra, Rajesh; Wallez, Yann; Wijnhoven, Paul W. G.; Hughes, Adina M.; Gerrard, Joe; Jones, Gemma N.; Bargh-Dawson, Hannah; Brown, Elaine; Young, Lucy A.; O'Connor, Mark J.; Lau, Alan 分享 收藏
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification 用于鉴定同源重组缺陷肿瘤和患者分层的RAD51测试的临床前体内验证 Pellegrino, Benedetta; Herencia-Ropero, Andrea; Llop-Guevara, Alba; Pedretti, Flaminia; Moles-Fernandez, Alejandro; Viaplana, Cristina; Villacampa, Guillermo; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Jimenez, Jose; Arenas, Enrique J.; Degasperi, Andrea; Dias, Joao M. L.; Forment, Josep, V; O'Connor, Mark J.; Deas, Olivier; Cairo, Stefano; Zhou, Yinghui; Musolino, Antonino; Caldas, Carlos; Nik-Zainal, Serena; Clarke, Robert B.; Nuciforo, Paolo; Diez, Orland; Serres-Creixams, Xavier; Peg, Vicente; Espinosa-Bravo, Martin; Macarulla, Teresa; Oaknin, Ana; Mateo, Joaquin; Arribas, Joaquin; Dienstmann, Rodrigo; Bellet, Meritxell; Oliveira, Mafalda; Saura, Cristina; Gutierrez-Enriquez, Sara; Balmana, Judith; Serra, Violeta 分享 收藏
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress Lloyd, Rebecca L.; Urban, Vaclav; Munoz-Martinez, Francisco; Ayestaran, Inigo; Thomas, John C.; de Renty, Christelle; O'Connor, Mark J.; Forment, Josep, V; Galanty, Yaron; Jackson, Stephen P. 分享 收藏
Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development Gill, Sonja J.; Wijnhoven, Paul W. G.; Fok, Jacqueline H. L.; Lloyd, Rebecca L.; Cairns, Jonathan; Armenia, Joshua; Nikkila, Jenni; Lau, Alan; Bakkenist, Christopher J.; Galbraith, Susan M.; Vens, Conchita; O'Connor, Mark J. 分享 收藏
Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model Jiang, Yanyan; Martin, Jennifer; Alkadhimi, Maryam; Shigemori, Kay; Kinchesh, Paul; Gilchrist, Stuart; Kersemans, Veerle; Smart, Sean; Thompson, James M.; Hill, Mark A.; O'Connor, Mark J.; Davies, Barry R.; Ryan, Anderson J. 分享 收藏
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