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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum Vaidya, Akhil B.; Morrisey, Joanne M.; Zhang, Zhongsheng; Das, Sudipta; Daly, Thomas M.; Otto, Thomas D.; Spillman, Natalie J.; Wyvratt, Matthew; Siegl, Peter; Marfurt, Jutta; Wirjanata, Grennady; Sebayang, Boni F.; Price, Ric N.; Chatterjee, Arnab; Nagle, Advait; Stasiak, Marcin; Charman, Susan A.; Angulo-Barturen, Inigo; Ferrer, Santiago; Belen Jimenez-Diaz, Maria; Santos Martinez, Maria; Javier Gamo, Francisco; Avery, Vicky M.; Ruecker, Andrea; Delves, Michael; Kirk, Kiaran; Berriman, Matthew; Kortagere, Sandhya; Burrows, Jeremy; Fan, Erkang; Bergman, Lawrence W. 分享 收藏
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain Chobanian, Harry R.; Guo, Yan; Liu, Ping; Chioda, Marc D.; Fung, Selena; Lanza, Thomas J.; Chang, Linda; Bakshi, Raman K.; Dellureficio, James P.; Hong, Qingmei; McLaughlin, Mark; Belyk, Kevin M.; Krska, Shane W.; Makarewicz, Amanda K.; Martel, Elliot J.; Leone, Joseph F.; Frey, Lisa; Karanam, Bindhu; Madeira, Maria; Alvaro, Raul; Shuman, Joyce; Salituro, Gino; Terebetski, Jenna L.; Jochnowitz, Nina; Mistry, Shruti; McGowan, Erin; Hajdu, Richard; Rosenbach, Mark; Abbadie, Catherine; Alexander, Jessica P.; Shiao, Lin-Lin; Sullivan, Kathleen M.; Nargund, Ravi P.; Wyvratt, Matthew J.; Lin, Linus S.; DeVita, Robert J. 分享 收藏
1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; DeMartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J. 分享 收藏
Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality Liu, Ping; Lanza, Thomas J., Jr.; Chioda, Marc; Jones, Carrie; Chobanian, Harry R.; Guo, Yan; Chang, Linda; Kelly, Theresa M.; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J.; Metzger, Joseph M.; Ramsay, Katie; Wang, Sheng-Ping; Strack, Alison M.; Miller, Randy; Pang, Jianmei; Lyons, Kathy; Dragovic, Jasminka; Ning, Jian G.; Schafer, Wes A.; Welch, Christopher J.; Gong, Xiaoyi; Gao, Ying-Duo; Hornak, Viktor; Ball, Richard G.; Tsou, Nancy; Reitman, Marc L.; Wyvratt, Matthew J.; Nargund, Ravi P.; Lin, Linus S. 分享 收藏
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity Sebhat, Iyassu K.; Franklin, Christopher; Lo, Michael M. -C.; Chen, David; Jewell, James P.; Miller, Randy; Pang, Jianmei; Palyha, Oksana; Kan, Yanqing; Kelly, Theresa M.; Guan, Xiao-Ming; Marsh, Donald J.; Kosinski, Jennifer A.; Metzger, Joseph M.; Lyons, Kathryn; Dragovic, Jasminka; Guzzo, Peter R.; Henderson, Alan J.; Reitman, Marc L.; Nargund, Ravi P.; Wyvratt, Matthew J.; Lin, Linus S. 分享 收藏
Discovery of the Development Candidate N-tert-Butyl Nodulisporamide: A Safe and Efficacious Once Monthly Oral Agent for the Control of Fleas and Ticks on Companion Animals Meinke, Peter T.; Colletti, Steven L.; Fisher, Michael H.; Wyvratt, Matthew J.; Shih, Thomas L.; Ayer, Michelle B.; Li, Chunshi; Lim, Julie; Ok, Dong; Salva, Steve; Warmke, Lynn M.; Zakson, Michelle; Michael, Bruce F.; deMontigny, Pierre; Ostlind, Dan A.; Fink, David; Drag, Marlene; Schmatz, Dennis M.; Shoop, Wesley L. 分享 收藏
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II Scribner, Andrew; Dennis, Richard; Lee, Shuliang; Ouvry, Gilles; Perrey, David; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye 分享 收藏
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing subsituted triazolopiperazines Kim, Dooseop; Kowalchick, Jennifer E.; Brockunier, Linda L.; Parmee, Emma R.; Eiermann, George J.; Fisher, Michael H.; He, Huaibing; Leiting, Barbara; Lyons, Kathryn; Scapin, Giovanna; Patel, Sangita B.; Petrov, Aleksandr; Pryor, KellyAnn D.; Roy, Ranabir Sinha; Wu, Joseph K.; Zhang, Xiaoping; Wyvratt, Matthew J.; Zhang, Bei B.; Zhu, Lan; Thornberry, Nancy A.; Weber, Ann E. 分享 收藏
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part I Scribner, Andrew; Dennis, Richard; Hong, Jean; Lee, Shuliang; McIntyre, Donald; Perrey, David; Feng, Dennis; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye 分享 收藏
(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes (2R)-4-氧代-4-[3-(三氟甲基)-5，6-二氢 [1,2，4] 三唑并 [4，3-α]pyrazin-7 (8h)-基]-1-(2,4，5-三氟苯基) butan-2-amine:: 一种有效的，口服活性二肽基肽酶IV抑制剂治疗2型糖尿病 Kim, D; Wang, LP; Beconi, M; Eiermann, GJ; Fisher, MH; He, HB; Hickey, GJ; Kowalchick, JE; Leiting, B; Lyons, K; Marsilio, F; McCann, ME; Patel, RA; Petrov, A; Scapin, G; Patel, SB; Roy, RS; Wu, JK; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE 分享 收藏
A NOVEL 3-SUBSTITUTED BENZAZEPINONE GROWTH-HORMONE SECRETAGOGUE (L-692,429) SCHOEN, WR; PISANO, JM; PRENDERGAST, TK; WYVRATT, MJ; FISHER, MH; CHENG, K; CHAN, WWS; BUTLER, B; SMITH, RG; BALL, RG 分享 收藏
Synthesis of side chain truncated 3-aldehyde, 3-carboxylic acid, and 1-aldehyde from nodulisporic acid A Chakravarty, PK; Tyagarajan, S; Shih, TL; Salva, S; Snedden, C; Wyvratt, MJ; Fisher, MH; Meinke, PT 分享 收藏
Synthesis of nodulisporic acid 2-oxazoles and 2-thiazoles Berger, R; Shoop, WL; Pivnichny, JV; Warmke, LM; Zakson-Aiken, M; Owens, KA; deMontigny, P; Schmatz, DM; Wyvratt, MJ; Fisher, MH; Meinke, PT; Colletti, SL 分享 收藏
A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor DeVita, RJ; Walsh, TF; Young, JR; Jiang, JL; Ujjainwalla, F; Toupence, RB; Parikh, M; Huang, SX; Fair, JA; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Cui, JS; Mount, G; Rohrer, SP; Schaeffer, JM; Rhodes, L; Drisko, JE; McGowan, E; MacIntyre, DE; Vincent, S; Carlin, JR; Cameron, J; Smith, RG 分享 收藏
Synthesis of apicidin-derived quinolone derivatives: Parasite-selective histone deacetylase inhibitors and antiproliferative agents Meinke, PT; Colletti, SL; Doss, G; Myers, RW; Gurnett, AM; Dulski, PM; Darkin-Rattray, SJ; Allocco, JJ; Galuska, S; Schmatz, DM; Wyvratt, MJ; Fisher, MH 分享 收藏
L-750355, a human β3-adrenoceptor agonist;: in vitro pharmacology and profile of activity in vivo in the rhesus monkey Forrest, MJ; Hom, G; Bach, T; Candelore, MR; Cascieri, MA; Strader, C; Tota, L; Fisher, MH; Szumiloski, J; Ok, HO; Weber, AE; Wyvratt, M; Vicario, P; Marko, O; Deng, LP; Cioffe, C; Hegarty-Friscino, B; MacIntyre, E 分享 收藏
Discovery of a potent, orally bioavailable β3 adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE 分享 收藏
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