Paul Shapiro - Publications, H-index & Citations

Paul Shapiro

University System of Maryland

38H指数

147论文数

6.7K被引数

收录论文 35

发表时间

Histone deacetylase (HDAC) inhibitor specificity determinants are preserved in a class of dual HDAC/non-covalent proteasome inhibitors 组蛋白去乙酰化酶 (HDAC) 抑制剂特异性决定因素被保留在一类双重HDAC/非共价蛋白酶体抑制剂中

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2024-04-01

PREAI

Chan, Alexandria M.; Mitchell, Ashley; Grogan, Lena; Shapiro, Paul; Fletcher, Steven

Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2023-01-01

OAAI

Shah, Sushrut D.; Nayak, Ajay P.; Sharma, Pawan; Villalba, Dominic R.; Addya, Sankar; Huang, Weiliang; Shapiro, Paul; Kane, Maureen A.; Deshpande, Deepak A.

Targeting mitochondrial metabolism for metastatic cancer therapy 靶向线粒体代谢治疗转移性癌症

MOLECULAR CARCINOGENESIS

IF3.2

2022-06-20

OAAI

Passaniti, Antonino; Kim, Myoung Sook; Polster, Brian M.; Shapiro, Paul

Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma

FASEB JOURNAL

IF4.2

2021-11-16

OAAI

Defnet, Amy E.; Shah, Sushrut D.; Huang, Weiliang; Shapiro, Paul; Deshpande, Deepak A.; Kane, Maureen A.

Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK 免疫调节纳米颗粒通过抑制PAMP相互作用和乳酸介导的nf-κb和p38 MAPK的功能性重编程来减轻巨噬细胞炎症

PHARMACEUTICS

IF5.5

2021-11-02

OAAI

Lasola, Jackline Joy Martin; Cottingham, Andrea L.; Scotland, Brianna L.; Nhu Truong; Hong, Charles C.; Shapiro, Paul; Pearson, Ryan M.

Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2021-01-01

OAAI

Martinez, Ramon, III; Huang, Weiliang; Samadani, Ramin; Mackowiak, Bryan; Centola, Garrick; Chen, Lijia; Conlon, Ivie L.; Hom, Kellie; Kane, Maureen A.; Fletcher, Steven; Shapiro, Paul

A temperature-dependent conformational shift in p38α MAPK substrate-binding region associated with changes in substrate phosphorylation profile

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-08-01

OAAI

Deredge, Daniel; Wintrode, Patrick L.; Tulapurkar, Mohan E.; Nagarsekar, Ashish; Zhang, Yinghua; Webei, David J.; Shapiro, Paul; Hasday, Jeffrey D.

Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2naphthoates as selective inhibitors of the Mcl-1 oncoprotein

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2016-05-01

OAAI

Lanning, Maryanna E.; Yu, Wenbo; Yap, Jeremy L.; Chauhan, Jay; Chen, Lijia; Whiting, Ellis; Pidugu, Lakshmi S.; Atkinson, Tyler; Bailey, Hala; Li, Willy; Roth, Braden M.; Hynicka, Lauren; Chesko, Kirsty; Toth, Eric A.; Shapiro, Paul; MacKerell, Alexander D., Jr.; Wilder, Paul T.; Fletcher, Steven

The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Germann, Ursula; Furey, Brinley; Roix, Jeff; Markland, William; Hoover, Russell; Aronov, Alex; Hale, Michael; Chen, Guanjing; Martinez-Botella, Gabriel; Alargova, Rossitza; Fan, Bin; Sorrell, David; Meshaw, Kay; Shapiro, Paul; Wick, Michael J.; Benes, Cyril; Garnett, Mathew; DeCrescenzo, Gary; Namchuk, Mark; Saha, Saurabh; Welsch, Dean J.

Complex Formation between S100B Protein and the p90 Ribosomal S6 Kinase ( RSK) in Malignant Melanoma Is Calcium-dependent and Inhibits Extracellular Signalregulated Kinase ( ERK)-mediated Phosphorylation of RSK

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-05-01

OAAI

Hartman, Kira G.; Vitolo, Michele I.; Pierce, Adam D.; Fox, Jennifer M.; Shapiro, Paul; Martin, Stuart S.; Wilder, Paul T.; Weber, David J.

A docking domain directed inhibitor targeting ERK regulated F-site substrates

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Zhang, Jun; Oashi, Taiji; Semadani, Ramin; Nevels, Kerrick; Burkhard, Kimberly; Priyakumar, Deva; Raman, Prabhu; Fletcher, Steven; Pozharsky, Edvin; Shapiro, Paul; MacKerell, Alexander

Febrile-range hyperthermia augments reversible TNF-α-induced hyperpermeability in human microvascular lung endothelial cells

INTERNATIONAL JOURNAL OF HYPERTHERMIA

IF3

2012-07-26

OAAI

Shah, Nirav G.; Tulapurkar, Mohan E.; Damarla, Mahendra; Singh, Ishwar S.; Goldblum, Simeon E.; Shapiro, Paul; Hasday, Jeffrey D.

Febrile-Range Hyperthermia Modifies Endothelial and Neutrophilic Functions to Promote Extravasation

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2012-06-01

OAAI

Tulapurkar, Mohan E.; Almutairy, Eid A.; Shah, Nirav G.; He, Ju-ren; Puche, Adam C.; Shapiro, Paul; Singh, Ishwar S.; Hasday, Jeffrey D.

Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling

JOURNAL OF PSYCHIATRIC RESEARCH

IF3.2

2012-01-01

PREAI

Regenold, W. T.; Pratt, M.; Nekkalapu, S.; Shapiro, P. S.; Kristian, T.; Fiskum, G.

Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma

NATURE COMMUNICATIONS

IF15.7

2011-07-19

OAAI

Dai, Bojie; Zhao, X. Frank; Mazan-Mamczarz, Krystyna; Hagner, Patrick; Corl, Sharon; Bahassi, El Mustapha; Lu, Song; Stambrook, Peter J.; Shapiro, Paul; Gartenhaus, Ronald B.

Quantitative Analysis of ERK2 Interactions with Substrate Proteins ROLES FOR KINASE DOCKING DOMAINS AND ACTIVITY IN DETERMINING BINDING AFFINITY

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-01-01

OAAI

Burkhard, Kimberly A.; Chen, Fengming; Shapiro, Paul

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

ALZHEIMERS RESEARCH & THERAPY

IF7.6

2010-12-29

OAAI

Basi, Guriqbal S.; Hemphill, Susanna; Brigham, Elizabeth F.; Liao, Anna; Aubele, Danielle L.; Baker, Jeanne; Barbour, Robin; Bova, Michael; Chen, Xiao-Hua; Dappen, Michael S.; Eichenbaum, Tovah; Goldbach, Erich; Hawkinson, Jon; Lawler-Herbold, Rose; Hu, Kang; Hui, Terence; Jagodzinski, Jacek J.; Keim, Pamela S.; Kholodenko, Dora; Latimer, Lee H.; Lee, Mike; Marugg, Jennifer; Mattson, Matthew N.; McCauley, Scott; Miller, James L.; Motter, Ruth; Mutter, Linda; Neitzel, Martin L.; Ni, Huifang; Lan Nguyen; Quinn, Kevin; Ruslim, Lany; Semko, Christopher M.; Shapiro, Paul; Smith, Jenifer; Soriano, Ferdie; Szoke, Balazs; Tanaka, Kevin; Tang, Pearl; Tucker, John A.; Ye, Xiacong Michael; Yu, Mei; Wu, Jing; Xu, Ying-zi; Garofalo, Albert W.; Sauer, John Michael; Konradi, Andrei W.; Ness, Daniel; Shopp, George; Pleiss, Michael A.; Freedman, Stephen B.; Schenk, Dale

Hyperglycemia Regulates RUNX2 Activation and Cellular Wound Healing through the Aldose Reductase Polyol Pathway

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-07-01

OAAI

D'Souza, David R.; Salib, Maryann M.; Bennett, Jessica; Mochin-Peters, Maria; Asrani, Kaushal; Goldblum, Simeon E.; Renoud, Keli J.; Shapiro, Paul; Passaniti, Antonino

Raf kinase inhibitory protein regulates Aurora B kinase and the spindle checkpoint

MOLECULAR CELL

IF16.6

2006-08-01

162

OAAI

Eves, Eva M.; Shapiro, Paul; Naik, Karuna; Klein, Ulf R.; Trakul, Nicholas; Rich Rosner, Marsha

Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity

BIOCHEMICAL JOURNAL

IF4.3

2006-06-28

OAAI

Raines, Kimberly W.; Cao, Guan-Liang; Lee, Eun Kyoung; Rosen, Gerald M.; Shapiro, Paul

研究方向