未登录 Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists Thomson, Christopher G.; Boss, Kelly; Calhoun, Amy; Fridrich, Cary; Gardinier, Kevin M.; Hall, Edward C.; Jendza, Keith; Kirman, Louise; Labbe-Giguere, Nancy; Laumen, Kurt; Qian, Ming; Sanyal, Sanjit; Shultz, Michael D.; Snajdrova, Radka; Tan, Kian; Wang, Kate Yaping; Yang, Fan; Gao, Feng; Hong, Tao; Dale, Elena; Kuzmiski, Brent; Ortuno, Danny; Palacios, Daniel S. 分享 收藏
Evolution of Novartis' Small Molecule Screening Deck Design 诺华小分子筛板设计的演变 Schuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K. 分享 收藏
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer LaMarche, Matthew J.; Acker, Michael; Argintaru, Andreea; Bauer, Daniel; Boisclair, Julie; Chan, Homan; Chen, Christine Hiu-Tung; Chen, Ying-Nan; Chen, Zhouliang; Deng, Zhan; Dore, Michael; Dunstan, David; Fan, Jianmei; Fekkes, Peter; Firestone, Brant; Fodor, Michelle; Garcia-Fortanet, Jorge; Fortin, Pascal D.; Fridrich, Cary; Giraldes, John; Glick, Meir; Grunenfelder, Denise; Hao, Huia-Xiang; Hentemann, Martin; Ho, Samuel; Jouk, Andriana; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; Koenig, Robert; LaBonte, Laura R.; Larrow, Jay; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Mathieu, Simon; Meyer, Matthew J.; Mohseni, Morvarid; Ntaganda, Rukundo; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Reilly, John; Sarver, Patrick; Sellers, William R.; Sendzik, Martin; Shultz, Michael D.; Slisz, Joanna; Slocum, Kelly; Smith, Troy; Spence, Stanley; Stams, Travis; Straub, Christopher; Tamez, Victoriano, Jr.; Toure, Bakary-Barry; Towler, Christopher; Wang, Ping; Wang, Hongyun; Williams, Sarah L.; Yang, Fan; Yu, Bing; Zhang, Ji-Hu; Zhu, Suzanne 分享 收藏
Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors (vol 62, pg 1781, 2019) Bagdanoff, Jeffrey T.; Chen, Zhouliang; Acker, Michael; Chen, Ying-Nan; Chan, Homan; Dore, Michael; Firestone, Brant; Fodor, Michelle; Fortanet, Jorge; Hentemann, Murphy; Kato, Mitsunori; Koenig, Robert; LaBonte, Laura R.; Liu, Shumei; Mohseni, Movarid; Ntaganda, Rukundo; Sarver, Patrick; Shultz, Michael D.; Smith, Troy; Sendzik, Martin; Stams, Travis; Spence, Stan; Towler, Christopher; Wang, Hongyun; Wang, Ping; Williams, Sarah L.; LaMarche, Matthew J. 分享 收藏
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors (vol 62, pg 1793, 2019) Sarver, Patrick; Acker, Michael; Bagdanoff, Jeffrey T.; Chen, Zhouliang; Chen, Ying-Nan; Chan, Homan; Firestone, Brant; Fodor, Michelle; Fortanet, Jorge; Hao, Huaixiang; Hentemann, Murphy; Jouk, Andriana; Kato, Mitsunori; Koenig, Robert; LaBonte, Laura R.; Liu, Gang; Liu, Shumei; Liu, Chen; McNeill, Eric; Mohseni, Morvarid; Shultz, Michael D.; Sendzik, Martin; Stams, Travis; Spence, Stan; Tamez, Victoriano; Tichkule, Ritesh; Towler, Christopher; Wang, Hongyun; Wang, Ping; Williams, Sarah L.; Yu, Bing; LaMarche, Matthew J. 分享 收藏
Simultaneous inhibition of SHP2 phosphatase at two allosteric sites Fodor, Michelle; Price, Edmund; Wang, Ping; Lu, Hengyu; Argintaru, Andreea; Chen, Zhouliang; Glick, Meir; Hao, Huai-Xiang; Kato, Mitsunori; Koenig, Robert; LaRochelle, Jonathan R.; Liu, Gang; McNeill, Eric; Majumdar, Dyuti; Nishiguchi, Gisele; Perez, Lawrence; Paris, Greg; Quinn, Christopher; Ramsey, Timothy; Sendzik, Martin; Shultz, Michael; Williams, Sarah; Stams, Travis; Blacklow, Stephen C.; LaMarche, Matthew J.; Acker, Michael G. 分享 收藏
Dual Allosteric Inhibition of SHP2 Phosphatase Fodor, Michelle; Price, Edmund; Wang, Ping; Lu, Hengyu; Argintaru, Andreea; Chen, Zhouliang; Glick, Meir; Hao, Huai-Xiang; Kato, Mitsunori; Koenig, Robert; LaRochelle, Jonathan R.; Liu, Gang; McNeill, Eric; Majumdar, Dyuti; Nishiguchi, Gisele A.; Perez, Lawrence B.; Paris, Gregory; Quinn, Christopher M.; Ramsey, Timothy; Sendzik, Martin; Shultz, Michael David; Williams, Sarah L.; Stams, Travis; Blacklow, Stephen C.; Acker, Michael G.; LaMarche, Matthew J. 分享 收藏
Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor Cho, Young Shin; Levell, Julian R.; Liu, Gang; Caferro, Thomas; Sutton, James; Shafer, Cynthia M.; Costales, Abran; Manning, James R.; Zhao, Qian; Sendzik, Martin; Shultz, Michael; Chenail, Gregg; Dooley, Julia; Villalba, Brian; Farsidjani, Ali; Chen, Jinyun; Kulathila, Raviraj; Xie, Xiaoling; Dodd, Stephanie; Gould, Ty; Liang, Guiqing; Heimbach, Tycho; Slocum, Kelly; Firestone, Brant; Pu, Minying; Pagliarini, Raymond; Growney, Joseph D. 分享 收藏
Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Acker, Michael G.; Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man; Fekkes, Peter; Garcia-Fortanet, Jorge; LaRochelle, Jonathan R.; Antonakos, Brandon; Chen, Christine Hiu-Tung; Chen, Zhuoliang; Cooke, Vesselina G.; Dobson, Jason R.; Deng, Zhan; Feng, Fei; Firestone, Brant; Fodor, Michelle; Fridrich, Cary; Gao, Hui; Hao, Huai-Xiang; Jacob, Jaison; Ho, Samuel; Hsiao, Kathy; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Larrow, Jay; La Bonte, Laura R.; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Pu, Minying; Price, Edmund; Shakya, Subarna; Shultz, Michael D.; Venkatesan, Kavitha; Wang, Ping; Warmuth, Markus; Williams, Sarah; Yang, Guizhi; Yuan, Jing; Zhang, Ji-Hu; Zhu, Ping; Blacklow, Stephen C.; Ramsey, Timothy; Keen, Nicholas J.; Sellers, William R.; Stams, Travis; Fortin, Pascal D. 分享 收藏
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy Huang, Ying; Zhang, Jeff; Yu, Zhengtian; Zhang, Hailong; Wang, Youzhen; Lingel, Andreas; Qi, Wei; Gu, Justin; Zhao, Kehao; Shultz, Michael D.; Wang, Long; Fu, Xingian; Sun, Yongfeng; Zhang, Qiong; Jiang, Xiangqing; Zhang, Jiangwei; Zhang, Chunye; Li, Ling; Zeng, Jue; Feng, Lijian; Zhang, Chao; Liu, Yueqin; Zhang, Man; Zhang, Lijun; Zhao, Mengxi; Gao, Zhenting; Liu, Xianghui; Fang, Douglas; Guo, Haibing; Mi, Yuan; Gabriel, Tobias; Dillon, Michael P.; Atadja, Peter; Oyang, Counde 分享 收藏
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase Lingel, Andreas; Sendzik, Martin; Huang, Ying; Shultz, Michael D.; Cantwell, John; Dillon, Michael P.; Fu, Xingnian; Fuller, John; Gabriel, Tobias; Gu, Justin; Jiang, Xiangqing; Li, Ling; Liang, Fang; McKenna, Maureen; Qi, Wei; Rao, Weijun; Sheng, Xijun; Shu, Wei; Sutton, James; Taft, Benjamin; Wang, Long; Zeng, Jue; Zhang, Hailong; Zhang, Maya; Zhao, Kehao; Lindvall, Mika; Bussiere, Dirksen E. 分享 收藏
Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKC Signaling Axis Shapiro, Brian A.; Vu, Ngoc T.; Shultz, Michael D.; Shultz, Jacqueline C.; Mietla, Jennifer A.; Gouda, Mazen M.; Yacoub, Adly; Dent, Paul; Fisher, Paul B.; Park, Margaret A.; Chalfant, Charles E. 分享 收藏
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor Fortanet, Jorge Garcia; Chen, Christine Hiu-Tung; Chen, Ying-Nan P.; Chen, Zhouliang; Deng, Zhan; Firestone, Brant; Fekkes, Peter; Fodor, Michelle; Fortin, Pascal D.; Fridrich, Cary; Grunenfelder, Denise; Ho, Samuel; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; LaBonte, Laura R.; Larrow, Jay; Lenoir, Francois; Liu, Gang; Liu, Shumei; Lombardo, Franco; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Sellers, William R.; Shultz, Michael D.; Stams, Travis; Towler, Christopher; Wang, Ping; Williams, Sarah L.; Zhang, Ji-Hu; LaMarche, Matthew J. 分享 收藏
Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms Spence, Stan; Deurinck, Mark; Ju, Haisong; Traebert, Martin; McLean, LeeAnne; Marlowe, Jennifer; Emotte, Corinne; Tritto, Elaine; Tseng, Min; Shultz, Michael; Friedrichs, Gregory S. 分享 收藏
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Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model Tan, Alex Y.; Hu, Yuhning L.; Potfay, Jonathan; Kaszala, Karoly; Howren, Maureen; Sima, Adam P.; Shultz, Michael; Koneru, Jayanthi N.; Ellenbogen, Kenneth A.; Huizar, Jose F. 分享 收藏
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Structure-Efficiency Relationship of [1,2,4]Triazol-3-ylamines as Novel Nicotinamide Isosteres that Inhibit Tankyrases Shultz, Michael D.; Majumdar, Dyuti; Chin, Donovan N.; Fortin, Pascal D.; Feng, Yun; Gould, Ty; Kirby, Christina A.; Stams, Travis; Waters, Nigel J.; Shao, Wenlin 分享 收藏
Identification of NVP-TNKS656: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor Shultz, Michael D.; Cheung, Atwood K.; Kirby, Christina A.; Firestone, Brant; Fan, Jianmei; Chen, Christine Hiu-Tung; Chen, Zhouliang; Chin, Donovan N.; DiPietro, Lucian; Fazal, Aleem; Feng, Yun; Fortin, Pascal D.; Gould, Ty; Lagu, Bharat; Lei, Huangshu; Lenoir, Francois; Majumdar, Dyuti; Ochala, Etienne; Palermo, M. G.; Ly Pham; Pu, Minying; Smith, Troy; Stams, Travis; Tomlinson, Ronald C.; Toure, B. Barry; Visser, Michael; Wang, Run Ming; Waters, Nigel J.; Shao, Wenlin 分享 收藏
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