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R
Ronald T. Borchardt
University of Kansas
66
H指数
562
论文数
1.7W
被引数
0
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68
发表时间
发表时间
IF
被引数
Absorption Barriers in the Rat Intestinal Mucosa: 2. Application of Physiologically Based Mathematical Models to Quantify Mechanisms of Drug Permeation and Metabolism
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2010-02-01
12
PRE
AI
Mudra, Daniel R.; Jin, Jin Y.; Borchardt, Ronald T.
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A Comparison of the Effects of P-Glycoprotein Inhibitors on the Blood-Brain Barrier Permeation of Cyclic Prodrugs of an Opioid Peptide (DADLE)
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2009-06-01
20
PRE
AI
Ouyang, Hui; Andersen, Thomas E.; Chen, Weiqing; Nofsinger, Reecca; Steffansen, Bente; Borchardt, Ronald T.
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Factors that Restrict Intestinal Cell Permeation of Cyclic Prodrugs of an Opioid Peptide (DADLE): Part II. Role of Metabolic Enzymes in the Intestinal Mucosa
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2009-01-01
6
PRE
AI
Ouyang, Hui; Chen, Weiqing; Andersen, Thomas E.; Steffansen, Bente; Borchardt, Ronald T.
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Synthesis of 5′-functionalized nucleosides:: S-Adenosylhomocysteine analogues with the carbon-5′ and sulfur atoms replaced by a vinyl or halovinyl unit
BIOORGANIC & MEDICINAL CHEMISTRY
IF
3
2008-05-01
10
OA
AI
Wnuk, Stanislaw F.; Sacasa, Pablo R.; Lewandowska, Elzbieta; Andrei, Daniela; Cai, Sumin; Borchardt, Ronald T.
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The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi
BIOORGANIC & MEDICINAL CHEMISTRY
IF
3
2007-12-01
40
OA
AI
Cai, Sumin; Li, Qing-Shan; Borchardt, Ronald T.; Kuczera, Krzysztof; Schowen, Richard L.
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Molecular dynamics simulations of domain motions of substrate-free S-adenosyl-L-homocysteine hydrolase in solution
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF
2.8
2007-10-11
12
PRE
AI
Hu, Chen; Fang, Jianwen; Borchardt, Ronald T.; Schowen, Richard L.; Kuczera, Krzysztof
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The effect of cosolutes on the isomerization of aspartic acid residues and conformational stability in a monoclonal antibody
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2007-07-01
37
PRE
AI
Wakankar, Aditya A.; Liu, Jun; Vandervelde, David; Wang, Y. John; Shire, Steven J.; Borchardt, Ronald T.
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Enzymes involved in the bioconversion of ester-based prodrugs
参与酯基前药生物转化的酶
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2006-06-01
371
PRE
AI
Liederer, Bianca M.; Borchardt, Ronald T.
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Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state
AAPS JOURNAL
IF
3.7
2006-03-01
15
OA
AI
Li, B; Schowen, RL; Topp, EM; Borchardt, RT
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Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides
JOURNAL OF MEDICINAL CHEMISTRY
IF
6.8
2006-02-02
18
PRE
AI
Liederer, BM; Fuchs, T; Vander Velde, D; Siahaan, TJ; Borchardt, RT
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Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2005-12-01
13
PRE
AI
Liederer, BM; Phan, KT; Ouyang, H; Borchardt, RT
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Deamidation of model β-turn cyclic peptides in the solid state
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2005-12-01
9
PRE
AI
Krogmeier, SL; Reddy, DS; Vander Velde, D; Lushington, GH; Siahaan, TJ; Middaugh, CR; Borchardt, RT; Topp, EM
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Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2005-10-01
37
PRE
AI
Liederer, BM; Borchardt, RT
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Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2005-08-01
20
PRE
AI
Li, B; O'Meara, MH; Lubach, JW; Schowen, RL; Topp, EM; Munson, EJ; Borchardt, RT
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Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase?
JOURNAL OF MEDICINAL CHEMISTRY
IF
6.8
2005-04-21
6
PRE
AI
Wang, MM; Zhang, JS; Andrei, D; Kuczera, K; Borchardt, RT; Wnuk, SF
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Effects of acidic n+1 residues on asparagine deamidation rates in solution and in the solid state
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2005-03-01
30
PRE
AI
Li, B; Gorman, EM; Moore, KD; Williams, T; Schowen, RL; Topp, EM; Borchardt, RT
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Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine.: Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects
JOURNAL OF MEDICINAL CHEMISTRY
IF
6.8
2004-09-08
18
PRE
AI
Wnuk, SF; Lewandowska, E; Sacasa, PR; Crain, LN; Zhang, JS; Borchardt, RT; De Clercq, E
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Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers
JOURNAL OF PHARMACEUTICAL SCIENCES
IF
3.8
2004-05-01
69
PRE
AI
Tang, FX; Hui, OY; Yang, JZ; Borchardt, RT
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Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2:: Synthesis and biological investigations
JOURNAL OF MEDICINAL CHEMISTRY
IF
6.8
2004-01-06
47
PRE
AI
Våbeno, J; Lejon, T; Nielsen, CU; Steffansen, B; Chen, WQ; Hui, OY; Borchardt, RT; Luthman, K
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Racemization of an asparagine residue during peptide deamidation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF
15.6
2003-08-28
35
PRE
AI
Li, B; Borchardt, RT; Topp, EM; VanderVelde, D; Schowen, RL
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