Stephen P. Keen - Publications, H-index & Citations

Stephen P. Keen

merck & company usa

17H指数

52论文数

674被引数

收录论文 15

发表时间

Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-06-06

PREAI

Maddess, Matthew L.; Cleator, Ed; Morimoto, Mariko; Goodyear, Adrian; Dieguez-Vazquez, Alejandro; Gibb, Andrew; Kirtley, Andy; Christensen, Melodie; Song, Chaohui; Peng, Feng; Alam, Mahbub; Keen, Stephen P.; Oliver, Steven F.

Lotka's wheel and the long arm of history: how does the distant past determine today's global rate of energy consumption?

EARTH SYSTEM DYNAMICS

IF7.2

2022-06-15

OAAI

Garrett, Timothy J.; Grasselli, Matheus R.; Keen, Stephen

Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octane

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-06-07

PREAI

Maddess, Matthew L.; Cleator, Ed; Morimoto, Mariko; Goodyear, Adrian; Dieguez-Vazquez, Alejandro; Gibb, Andrew; Kirtley, Andy; Wang, Jie; Qi, Ji; Kong, Lingzhu; Alam, Mahbub; Keen, Stephen; Oliver, Steven F.; Wen, Xin; Lam, Yu-Hong

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

ORGANIC LETTERS

IF5

2017-02-06

PREAI

McLaughlin, Mark; Kong, Jongrock; Belyk, Kevin M.; Chen, Billy; Gibson, Andrew W.; Keen, Stephen P.; Lieberman, David R.; Milczek, Erika M.; Moore, Jeffrey C.; Murray, David; Peng, Feng; Qi, Ji; Reamer, Robert A.; Song, Zhiguo J.; Tan, Lushi; Wang, Lin; Williams, Michael J.

Process Development of the HCV NS5B Site D Inhibitor MK-8876

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2016-07-01

PREAI

Williams, Michael J.; Chen, Qinghao; Codan, Lorenzo; Dermenjian, Renee K.; Dreher, Spencer; Gibson, Andrew W.; He, Xianliang; Jin, Yan; Keen, Stephen P.; Lee, Alfred Y.; Lieberman, David R.; Lin, Wei; Liu, Guiquan; McLaughlin, Mark; Reibarkh, Mikhail; Scott, Jeremy P.; Strickfuss, Sophie; Tan, Lushi; Varsolona, Richard J.; Wen, Feng

Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2014-03-13

PREAI

Maddess, Matthew L.; Scott, Jeremy P.; Alorati, Anthony; Baxter, Carl; Bremeyer, Nadine; Brewer, Sarah; Campos, Kevin; Cleator, Ed; Dieguez-Vazquez, Alejandro; Gibb, Andrew; Gibson, Andrew; Howard, Melissa; Keen, Stephen; Klapars, Artis; Lee, Jaemoon; Li, Jing; Lynch, Joseph; Mullens, Peter; Wallace, Debra; Wilson, Robert

Enantioselective Synthesis of β-Aryloxycarboxylic Esters via Asymmetric Hydrogenation of β-Aryloxy-α,β-Unsaturated Esters

ORGANIC LETTERS

IF5

2012-10-16

PREAI

Stewart, Gavin W.; Shevlin, Michael; Yamagata, Adam D. Gammack; Gibson, Andrew W.; Keen, Stephen P.; Scott, Jeremy P.

Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide-Ethylene Diamine Complex

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2011-12-07

PREAI

Bassan, Ephraim M.; Baxter, Carl A.; Beutner, Gregory L.; Emerson, Khateeta M.; Fleitz, Fred J.; Johnson, Simon; Keen, Stephen; Kim, Mary M.; Kuethe, Jeffrey T.; Leonard, William R.; Mullens, Peter R.; Muzzio, Daniel J.; Roberge, Christopher; Yasuda, Nobuyoshi

Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2011-06-09

PREAI

Wallace, Debra J.; Baxter, Carl A.; Brands, Karel J. M.; Bremeyer, Nadine; Brewer, Sarah E.; Desmond, Richard; Emerson, Khateeta M.; Foley, Jennifer; Fernandez, Paul; Hu, Weifeng; Keen, Stephen P.; Mullens, Peter; Muzzio, Daniel; Sajonz, Peter; Tan, Lushi; Wilson, Robert D.; Zhou, George; Zhou, Guoyue

Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2010-06-02

PREAI

Stewart, Gavin W.; Brands, Karel M. J.; Brewer, Sarah E.; Cowden, Cameron J.; Davies, Antony J.; Edwards, John S.; Gibson, Andrew W.; Hamilton, Simon E.; Katz, Jason D.; Keen, Stephen P.; Mullens, Peter R.; Scott, Jeremy P.; Wallace, Debra J.; Wise, Christopher S.

Practical asymmetric synthesis of a γ-secretase inhibitor exploiting substrate-controlled intramolecular nitrile oxide-olefin cycloaddition

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2006-03-11

PREAI

Scott, JP; Oliver, SF; Brands, KMJ; Brewer, SE; Davies, AJ; Gibb, AD; Hands, D; Keen, SP; Sheen, FJ; Reamer, RA; Wilson, RD; Dolling, UH

Stereoselective total syntheses and reassignment of stereochemistry of the freshwater cyanobacterial hepatotoxins cylindrospermopsin and 7-epicylindrospermopsin

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2002-03-22

PREAI

Heintzelman, GR; Fang, WK; Keen, SP; Wallace, GA; Weinreb, SM