未登录 Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity Beebe, Xenia; Darczak, Daria; Henry, Rodger F.; Vortherms, Timothy; Janis, Richard; Namovic, Marian; Donnelly-Roberts, Diana; Kage, Karen L.; Surowy, Carol; Milicic, Ivan; Niforatos, Wende; Swensen, Andrew; Marsh, Kennan C.; Wetter, Jill M.; Franklin, Pamela; Baker, Scott; Zhong, Chengmin; Simler, Gricelda; Gomez, Erica; Boyce-Rustay, Janel M.; Zhu, Chang Z.; Stewart, Andrew O.; Jarvis, Michael F.; Scott, Victoria E. 分享 收藏
A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats Scott, Victoria E.; Vortherms, Timothy A.; Niforatos, Wende; Swensen, Andrew M.; Neelands, Torben; Milicic, Ivan; Banfor, Patricia N.; King, Andrew; Zhong, Chengmin; Simler, Gricelda; Zhan, Cenchen; Bratcher, Natalie; Boyce-Rustay, Janel M.; Zhu, Chang Z.; Bhatia, Pramila; Doherty, George; Mack, Helmut; Stewart, Andrew O.; Jarvis, Michael F. 分享 收藏
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist El-Kouhen, O.; Lehto, S. G.; Pan, J. B.; Chang, R.; Baker, S. J.; Zhong, C.; Hollingsworth, P. R.; Mikusa, J. P.; Cronin, E. A.; Chu, K. L.; McGaraughty, S. P.; Uchic, M. E.; Miller, L. N.; Rodell, N. M.; Patel, M.; Bhatia, P.; Mezler, M.; Kolasa, T.; Zheng, G. Z.; Fox, G. B.; Stewart, A. O.; Decker, M. W.; Moreland, R. B.; Brioni, J. D.; Honore, P. 分享 收藏
Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors Wang, Xueqing; Sarris, Katerina; Kage, Karen; Zhang, Di; Brown, Scott P.; Kolasa, Teodozyi; Surowy, Carol; El Kouhen, Odile F.; Muchmore, Steven W.; Brioni, Jorge D.; Stewart, Andrew O. 分享 收藏
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats Zhu, Chang Z.; Baker, Scott; El-Kouhen, Odile; Lehto, Sonya G.; Hollingsworth, Peter R.; Gauvin, Donna M.; Hernandez, Gricelda; Zheng, GuoZhu; Chang, Renjie; Moreland, Robert B.; Stewart, Andrew O.; Bnioni, Jorge D.; Honore, Prisca 分享 收藏
4-amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors 4-氨基-5-芳基-6-芳基乙炔基嘧啶: 非核苷腺苷激酶抑制剂的构效关系 Matulenko, Mark A.; Paight, Ernest S.; Frey, Robin R.; Gomtsyan, Arthur; DiDomenico, Stanley, Jr.; Jiang, Meiqun; Lee, Chih-Hung; Stewart, Andrew O.; Yu, Haixia; Kohlhaas, Kathy L.; Alexander, Karen M.; McGaraughty, Steve; Mikusa, Joseph; Marsh, Kennan C.; Muchmore, Steven W.; Jakob, Clarissa L.; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Bhagwat, Shripad S. 分享 收藏
Discovery of 3-methyl-N-(1-oxy-3′,4′,5′,6′-tetrahydro-2′H-[2,4′-bipyridine]-1′-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O. 分享 收藏
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes Muchmore, Steven W.; Smith, Richard A.; Stewart, Andrew O.; Cowart, Marlon D.; Gomtsyan, Arthur; Matulenko, Mark A.; Yu, Haixia; Severin, Jean M.; Bhagwat, Shripad S.; Lee, Chih-Hung; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Jakob, Clarissa L. 分享 收藏
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1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction Kolasa, Teodozyj; Matulenko, Mark A.; Hakeem, Ahmed A.; Patel, Meena V.; Mortell, Kathleen; Bhatia, Pramila; Henry, Rodger; Nakane, Masaki; Hsieh, Gin C.; Terranova, Marc A.; Uchic, Marie E.; Miller, Loan N.; Chang, Renje; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Martino, Brenda; El Kouhen, Odile; Marsh, Kennan C.; Wetter, Jill M.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O. 分享 收藏
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels (vol 117, pg 88, 2005) Dubé, GR; Lehto, SG; Breese, NM; Baker, SJ; Wang, XQ; Matulenko, MA; Honoré, P; Stewart, AO; Moreland, RB; Brioni, JD 分享 收藏
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists Zheng, GZ; Bhatia, P; Daanen, J; Kolasa, T; Patel, M; Latshaw, S; El Kouhen, OF; Chang, RJ; Uchic, ME; Miller, L; Nakane, M; Lehto, SG; Honore, MP; Moreland, RB; Brioni, JD; Stewart, AO 分享 收藏
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels Dubé, GR; Lehto, SG; Breese, NM; Baker, SJ; Wang, XQ; Matulenko, MA; Honoré, P; Stewart, AO; Moreland, RB; Brioni, JD 分享 收藏
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists Wang, XQ; Bhatia, PA; Daanen, JF; Latsaw, SP; Rohde, J; Kolasa, T; Hakeem, AA; Matulenko, MA; Nakane, M; Uchic, ME; Miller, LN; Chang, RJ; Moreland, RB; Brioni, JD; Stewart, AO 分享 收藏
5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido-[2,3-d]pyrimidin-4-ylamine:: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors Matulenko, MA; Lee, CH; Jiang, M; Frey, RR; Cowart, MD; Bayburt, EK; DiDomenico, S; Gfesser, GA; Gomtsyan, A; Zheng, GZ; McKie, JA; Stewart, AO; Yu, HX; Kohlhaas, KL; Alexander, KM; McGaraughty, S; Wismer, CT; Mikusa, J; Marsh, KC; Snyder, RD; Diehl, MS; Kowaluk, EA; Jarvis, MF; Bhagwat, SS 分享 收藏
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Synthesis and functional activity of (2-aryl-1-piperazinyl)N-(3-methylphenyl)acetamides:: selective dopamine D4 receptor agonists Matulenko, MA; Hakeem, AA; Kolasa, T; Nakane, M; Terranova, MA; Uchic, ME; Miller, LN; Chang, RJ; Donnelly-Roberts, DL; Namovic, MT; Moreland, RB; Brioni, JD; Stewart, AO 分享 收藏
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction Cowart, M; Latshaw, SP; Bhatia, P; Daanen, JF; Rohde, J; Nelson, SL; Patel, M; Kolasa, T; Nakane, M; Uchic, ME; Miller, LN; Terranova, MA; Hang, RJ; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, BR; Lynch, JJ; Sullivan, JP; Hsieh, GC; Moreland, RB; Brioni, JD; Stewart, AO 分享 收藏
Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats Brioni, JD; Moreland, RB; Cowart, M; Hsieh, GC; Stewart, AO; Hedlund, P; Donnelly-Roberts, DL; Nakane, M; Lynch, JJ; Kolasa, T; Polakowski, JS; Osinski, MA; Marsh, K; Andersson, KE; Sullivan, JP 分享 收藏
Dopamine D4 ligands and models of receptor activation:: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning Stewart, AO; Cowart, MD; Moreland, RB; Latshaw, SP; Matulenko, MA; Bhatia, PA; Wang, XQ; Daanen, JF; Nelson, SL; Terranova, MA; Namovic, MT; Donnelly-Roberts, DL; Miller, LN; Nakane, M; Sullivan, JP; Brioni, JD 分享 收藏
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