未登录 Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target Wilson, Caroline; Ray, Peter; Zuccotto, Fabio; Hernandez, Jorge; Aggarwal, Anup; Mackenzie, Claire; Caldwell, Nicola; Taylor, Malcolm; Huggett, Margaret; Mathieson, Michael; Murugesan, Dinakaran; Smith, Alasdair; Davis, Susan; Cocco, Mattia; Parai, Maloy K.; Acharya, Arjun; Tamaki, Fabio; Scullion, Paul; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Lopez-Roman, Eva Maria; Torres-Gomez, Pedro Alfonso; Toledo, Ana Maria; Guijarro-Lopez, Laura; Camino, Isabel; Engelhart, Curtis A.; Schnappinger, Dirk; Massoudi, Lisa M.; Lenaerts, Anne; Robertson, Gregory T.; Walpole, Chris; Matthews, David; Floyd, David; Sacchettini, James C.; Read, Kevin D.; Encinas, Lourdes; Bates, Robert H.; Green, Simon R.; Wyatt, Paul G. 分享 收藏
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis Baragana, Beatriz; Forte, Barbara; Choi, Ryan; Hewitt, Stephen Nakazawa; Bueren-Calabuig, Juan A.; Pisco, Joao Pedro; Peet, Caroline; Dranow, David M.; Robinson, David A.; Jansen, Chimed; Norcross, Neil R.; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F.; Cooper, Caitlin A.; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E.; Hallyburton, Irene; Horst, BenjaminG.; Hulverson, Matthew A.; Ferguson, Liam; Belen Jimenez-Diaz, Maria; Jumani, Rajiv S.; Lorimer, Donald D.; Love, Melissa S.; Maher, Steven; Matthews, Holly; McNamara, Casew.; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K.; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M.; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M.; Shishikura, Yoko; Simeons, Frederick R. C.; Stebbins, Erin E.; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K.; Tamjar, Jevgenia; Torrie, Leah S.; Vantaux, Amelie; Witkowski, Benoit; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Inigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Maser, Pascal; Kyle, Dennis E.; Winzeler, Elizabeth A.; Myler, Peter J.; Wyatt, Paul G.; Floyd, David; Matthews, David; Sharmao, Amit; Striepen, Boris; Huston, Christopher D.; Gray, David W.; Fairlamb, Alan H.; Pisliakov, Andrei V.; Walpole, Chris; Read, Kevin D.; Van Voorhis, Wesley C.; Gilbert, Ian H. 分享 收藏
Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides Floyd, David M.; Stein, Philip; Wang, Zheng; Liu, Jian; Castro, Steve; Clark, Julie A.; Connelly, Michele; Zhu, Fangyi; Holbrook, Gloria; Matheny, Amy; Sigal, Martina S.; Min, Jaeki; Dhinakaran, Rajkumar; Krishnan, Senthil; Bashyum, Sridevi; Knapp, Spencer; Guy, R. Kiplin 分享 收藏
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium Belen Jimenez-Diaz, Maria; Ebert, Daniel; Salinas, Yandira; Pradhan, Anupam; Lehane, Adele M.; Myrand-Lapierre, Marie-Eve; O'Loughlin, Kathleen G.; Shackleford, David M.; de Almeida, Mariana Justino; Carrillo, Angela K.; Clark, Julie A.; Dennis, Adelaide S. M.; Diep, Jonathon; Deng, Xiaoyan; Duffy, Sandra; Endsley, Aaron N.; Fedewa, Greg; Guiguemde, W. Armand; Gomez, Maria G.; Holbrook, Gloria; Horst, Jeremy; Kim, Charles C.; Liu, Jian; Lee, Marcus C. S.; Matheny, Amy; Santos Martinez, Maria; Miller, Gregory; Rodriguez-Alejandre, Ane; Sanz, Laura; Sigal, Martina; Spillman, Natalie J.; Stein, Philip D.; Wang, Zheng; Zhu, Fangyi; Waterson, David; Knapp, Spencer; Shelat, Anang; Avery, Vicky M.; Fidock, David A.; Gamo, Francisco-Javier; Charman, Susan A.; Mirsalis, Jon C.; Ma, Hongshen; Ferrer, Santiago; Kirk, Kiaran; Angulo-Barturen, Inigo; Kyle, Dennis E.; DeRisi, Joseph L.; Floyd, David M.; Guy, R. Kiplin 分享 收藏
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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential Coteron, Jose M.; Marco, Maria; Esquivias, Jorge; Deng, Xiaoyi; White, Karen L.; White, John; Koltun, Maria; El Mazouni, Farah; Kokkonda, Sreekanth; Katneni, Kasiram; Bhamidipati, Ravi; Shackleford, David M.; Angulo-Barturen, Inigo; Ferrer, Santiago B.; Belen Jimenez-Diaz, Maria; Gamo, Francisco-Javier; Goldsmith, Elizabeth J.; Charman, William N.; Bathurst, Ian; Floyd, David; Matthews, David; Burrows, Jeremy N.; Rathod, Pradipsinh K.; Charman, Susan A.; Phillips, Margaret A. 分享 收藏
Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice Gujjar, Ramesh; El Mazouni, Farah; White, Karen L.; White, John; Creason, Sharon; Shackleford, David M.; Deng, Xiaoyi; Charman, William N.; Bathurst, Ian; Burrows, Jeremy; Floyd, David M.; Matthews, David; Buckner, Frederick S.; Charman, Susan A.; Phillips, Margaret A.; Rathod, Pradipsinh K. 分享 收藏
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase Van Voorhis, Wesley C.; Rivas, Kasey L.; Bendale, Pravin; Nallan, Laxman; Horney, Carolyn; Barrett, Lynn K.; Bauer, Kevin D.; Smart, Brian P.; Ankala, Sudha; Hucke, Oliver; Verlinde, Christophe L. M. J.; Chakrabarti, Debopam; Strickland, Corey; Yokoyama, Kohei; Buckner, Frederick S.; Hamilton, Andrew D.; Williams, David K.; Lombardo, Louis J.; Floyd, David; Gelb, Michael H. 分享 收藏
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials Bendale, Pravin; Olepu, Srinivas; Suryadevara, Praveen Kumar; Bulbule, Vivek; Rivas, Kasey; Nallan, Laxman; Smart, Brian; Yokoyama, Kohei; Ankala, Sudha; Pendyala, Prakash Rao; Floyd, David; Lombardo, Louis J.; Williams, David K.; Buckner, Frederick S.; Chakrabarti, Debopam; Verlinde, Christophe L. M. J.; Van Voorhis, Wesley C.; Gelb, Michael H. 分享 收藏
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity Nallan, L; Bauer, KD; Bendale, P; Rivas, K; Yokoyama, K; Hornéy, CP; Pendyala, PR; Floyd, D; Lombardo, LJ; Williams, DK; Hamilton, A; Sebti, S; Windsor, WT; Weber, PC; Buckner, FS; Chakrabarti, D; Gelb, MH; Van Voorhis, WC 分享 收藏
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