Irit Lax - Publications, H-index & Citations

Irit Lax

Yale University

54H指数

140论文数

1.4W被引数

收录论文 36

发表时间

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

125

OAAI

Melillo, RM; Santoro, M; Ong, SH; Billaud, M; Fusco, A; Hadari, YR; Schlessinger, J; Lax, I

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

338

OAAI

Ong, SH; Guy, GR; Hadari, YR; Laks, S; Gotoh, N; Schlessinger, J; Lax, I

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

338

OAAI

Hadari, YR; Kouhara, H; Lax, I; Schlessinger, J

Lacrimo-auricuto-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathwayv

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Shams, Imad; Rohmann, Edyta; Eswarakumar, Veraragavan P.; Lew, Erin D.; Yuzawa, Satoru; Wollnik, Bernd; Schlessinger, Joseph; Lax, Irit

The docking protein FRS2α is an essential component of multiple fibroblast growth factor responses during early mouse development

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Gotoh, N; Manova, K; Tanaka, S; Murohashi, M; Hadari, Y; Lee, A; Hamada, Y; Hiroe, T; Ito, M; Kurihara, T; Nakazato, H; Shibuya, M; Lax, I; Lacy, E; Schlessinger, J

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Lamothe, B; Yamada, M; Schaeper, U; Birchmeier, W; Lax, I; Schlessinger, J

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-21

OAAI

Krimmer, Stefan G.; Bertoletti, Nicole; Suzuki, Yoshihisa; Katic, Luka; Mohanty, Jyotidarsini; Shu, Sheng; Lee, Sangwon; Lax, Irit; Mi, Wei; Schlessinger, Joseph

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-02-06

OAAI

An, Seong J.; Mohanty, Jyotidarsini; Tome, Francisco; Suzuki, Yoshihisa; Lax, Irit; Schlessinger, Joseph

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-11-30

OAAI

Suzuki, Yoshihisa; Kuzina, Ekaterina; An, Seong J.; Tome, Francisco; Mohanty, Jyotidarsini; Li, Wenxue; Lee, Sangwon; Liu, Yansheng; Lax, Irit; Schlessinger, Joseph

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-04-03

OAAI

Kuzina, Ekaterina S.; Ung, Peter Man-Un; Mohanty, Jyotidarsini; Tome, Francisco; Choi, Jungyuen; Pardon, Els; Steyaert, Jan; Lax, Irit; Schlessinger, Avner; Schlessinger, Joseph; Le, Sangwon

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α)

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-07-30

OAAI

Reshetnyak, Andrey V.; Mohanty, Jyotidarsini; Tome, Francisco; Puleo, David E.; Plotnikov, Alexander N.; Ahmed, Mansoor; Kaur, Navjot; Poliakov, Anton; Cinnaiyan, Arul M.; Lax, Irit; Schlessinger, Joseph

Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-08-01

OAAI

Shi, Xiarong; Sousa, Leiliane P.; Mandel-Bausch, Elizabeth M.; Tome, Francisco; Reshetnyak, Andrey V.; Hadari, Yaron; Schlessinger, Joseph; Lax, Irit

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-11-16

123

OAAI

Reshetnyak, Andrey V.; Murray, Phillip B.; Shi, Xiarong; Mo, Elizabeth S.; Mohanty, Jyotidarsini; Tome, Francisco; Bai, Hanwen; Gunel, Murat; Lax, Irit; Schlessinger, Joseph

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK

SCIENCE SIGNALING

IF6.6

2015-01-20

PREAI

Murray, Phillip B.; Lax, Irit; Reshetnyak, Andrey; Ligon, Gwenda F.; Lillquist, Jay S.; Natoli, Edward J., Jr.; Shi, Xiarong; Folta-Stogniew, Ewa; Gunel, Murat; Alvarado, Diego; Schlessinger, Joseph

The Strength and Cooperativity of KIT Ectodomain Contacts Determine Normal Ligand-Dependent Stimulation or Oncogenic Activation in Cancer

MOLECULAR CELL

IF16.6

2015-01-01

OAAI

Reshetnyak, Andrey V.; Opatowsky, Yarden; Boggon, Titus J.; Folta-Stogniew, Ewa; Tome, Francisco; Lax, Irit; Schlessinger, Joseph

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities

ELIFE

IF0

2014-09-29

258

OAAI

Lew, Erin D.; Oh, Jennifer; Burrola, Patrick G.; Lax, Irit; Zagorska, Anna; Traves, Paqui G.; Schlessinger, Joseph; Lemke, Greg

The docking protein FRS2α is a critical regulator of VEGF receptors signaling

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-04-02

OAAI

Chen, Pei-Yu; Qin, Lingfeng; Zhuang, Zhen W.; Tellides, George; Lax, Irit; Schlessinger, Joseph; Simons, Michael

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-01-21

OAAI

Opatowsky, Yarden; Lax, Irit; Tome, Francisco; Bleichert, Franziska; Unger, Vinzenz M.; Schlessinger, Joseph

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-10-14

OAAI

Reshetnyak, Andrey V.; Nelson, Bryce; Shi, Xiarong; Boggon, Titus J.; Pavlenco, Alevtina; Mandel-Bausch, Elizabeth M.; Tome, Francisco; Suzuki, Yoshihisa; Sidhu, Sachdev S.; Lax, Irit; Schlessinger, Joseph

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-02-27

157

OAAI

Sousa, Leiliane P.; Lax, Irit; Shen, Hongying; Ferguson, Shawn M.; De Camilli, Pietro; Schlessinger, Joseph

研究方向