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B

Barbara DeNearing

Johns Hopkins University
H指数:20
被引数:1,152

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Intestinal inflammation induced by heat-labile toxin-producing enterotoxigenic E: Coli infection and impact on immune responses in an experimental human challenge model

由产热不稳定性毒素的产肠毒素大肠杆菌(E: Coli)感染诱导的肠道炎症及其对免疫反应的影响：一项实验性人体挑战模型研究

PLOS NEGLECTED TROPICAL DISEASES
IF3.4
2025-10-010
PRE
Zhang, Xueyan; Brubaker, Jessica; Talaat, Kawsar R.; Porter, Chad K.; Feijoo, Brittany L.; Adjoodani, Brittany M.; DeNearing, Barbara; Prouty, Michael G.; Bourgeois, A. Louis; Sack, David A.; Eder-Lingelbach, Susanne; Taucher, Christian; Chakraborty, Subhra
Validation of a Human Challenge Model Using an LT-Expressing Enterotoxigenic E. coli Strain (LSN03-016011) and Characterization of Potential Amelioration of Disease by an Investigational Oral Vaccine Candidate (VLA1701)
MICROORGANISMS
IF4.2
2024-04-030
OAAI
Talaat, Kawsar R.; Porter, Chad K.; Chakraborty, Subhra; Feijoo, Brittany L.; Brubaker, Jessica; Adjoodani, Brittany M.; Denearing, Barbara; Prouty, Michael G.; Poole, Steven T.; Bourgeois, A. Louis; Billingsley, Madison; Sack, David A.; Eder-Lingelbach, Susanne; Taucher, Christian
Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic Escherichia coli CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic E. coli H10407 in Healthy Adult Volunteers
MICROORGANISMS
IF4.2
2024-01-296
OAAI
Gutierrez, Ramiro L.; Porter, Chad K.; Harro, Clayton; Talaat, Kawsar; Riddle, Mark S.; Denearing, Barbara; Brubaker, Jessica; Maciel Jr, Milton; Laird, Renee M.; Poole, Steven; Chakraborty, Subra; Maier, Nicole; Sack, David A.; Savarino, Stephen J.
Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection
EBIOMEDICINE
IF10.8
2021-04-0149
OAAI
Talaat, Kawsar R.; Alaimo, Cristina; Martin, Patricia; Bourgeois, A. Louis; Dreyer, Anita M.; Kaminski, Robert W.; Porter, Chad K.; Chakraborty, Subhra; Clarkson, Kristen A.; Brubaker, Jessica; Elwood, Daniel; Froehlich, Rahel; DeNearing, Barbara; Weerts, Hailey; Feijoo, Brittany L.; Halpern, Jane; Sack, David; Riddle, Mark S.; Fonck, Veronica Gambillara
Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine
EBIOMEDICINE
IF10.8
2021-04-0133
OAAI
Clarkson, Kristen A.; Talaat, Kawsar R.; Alaimo, Cristina; Martin, Patricia; Bourgeois, A. Louis; Dreyer, Anita; Porter, Chad K.; Chakraborty, Subhra; Brubaker, Jessica; Elwood, Daniel; Frolich, Rahel; DeNearing, Barbara; Weerts, Hailey P.; Feijoo, Brittany; Halpern, Jane; Sack, David; Riddle, Mark S.; Fonck, Veronica Gambillara; Kaminski, Robert W.
Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea
GUT MICROBES
IF11
2020-03-135
OAAI
Talaat, K. R.; Porter, C. K.; Bourgeois, A. L.; Lee, T. K.; Duplessis, C. A.; Maciel, M., Jr.; Gutierrez, R. L.; DeNearing, B.; Adjoodani, B.; Adkinson, R.; Testa, K. J.; Feijoo, B.; Alcala, A. N.; Brubaker, J.; Beselman, A.; Chakraborty, S.; Sack, D.; Halpern, J.; Trop, S.; Wu, H.; Jiao, J.; Sullivan, E.; Riddle, M. S.; Joseph, S. S.; Poole, S. T.; Prouty, M. G.
Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity (vol 128, pg 3298, 2018)
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2019-07-012
OA
Kumar, Pardeep; Kuhlmann, F. Matthew; Chakraborty, Subhra; Bourgeois, A. Louis; Foulke-Abel, Jennifer; Tumala, Brunda; Vickers, Tim J.; Sack, David A.; DeNearing, Barbara; Harro, Clayton D.; Wright, W. Shea; Gildersleeve, Jeffrey C.; Ciorba, Matthew A.; Santhanam, Srikanth; Porter, Chad K.; Gutierrez, Ramiro L.; Prouty, Michael G.; Riddle, Mark S.; Polino, Alexander; Sheikh, Alaullah; Donowitz, Mark; Fleckenstein, James M.
Enterotoxigenic E. coli virulence gene regulation in human infections
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2018-08-2049
OAAI
Crofts, Alexander A.; Giovanetti, Simone M.; Rubin, Erica J.; Poly, Frederic M.; Gutierrez, Ramiro L.; Talaat, Kawsar R.; Porter, Chad K.; Riddle, Mark S.; DeNearing, Barbara; Brubaker, Jessica; Maciel, Milton, Jr.; Alcala, Ashley N.; Chakraborty, Subhra; Prouty, Michael G.; Savarino, Stephen J.; Davies, Bryan W.; Trent, M. Stephen
Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2018-06-2540
OA
Kumar, Pardeep; Kuhlmann, F. Matthew; Chakraborty, Subhra; Bourgeois, A. Louis; Foulke-Abel, Jennifer; Tumala, Brunda; Vickers, Tim J.; Sack, David A.; DeNearing, Barbara; Harro, Clayton D.; Wright, W. Shea; Gildersleeve, Jeffrey C.; Ciorba, Matthew A.; Santhanam, Srikanth; Porter, Chad K.; Gutierrez, Ramiro L.; Prouty, Michael G.; Riddle, Mark S.; Polino, Alexander; Sheikh, Alaullah; Donowitz, Mark; Fleckenstein, James M.
Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development

用产肠毒素的大肠杆菌进行的人类实验挑战引发了对与疫苗开发相关的规范和新抗原的免疫反应

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2018-05-2441
OAAI
Chakraborty, Subhra; Randall, Arlo; Vickers, Tim J.; Molina, Doug; Harm, Clayton D.; DeNearing, Barbara; Brubaker, Ljessica; Sack, David A.; Bourgeois, A. Louis; Felgner, Philip L.; Liang, Xiaowu; Mani, Sachin; Wenzel, Heather; Townsend, R. Reid; Gilmore, Petra E.; Darsley, Michael J.; Rasko, David A.; Fleckenstein, James M.
Rifaximin Fails to Prevent Campylobacteriosis in the Human Challenge Model: A Randomized, Double-Blind, Placebo-Controlled Trial
CLINICAL INFECTIOUS DISEASES
IF7.3
2017-11-1414
OAAI
Rimmer, Joanna E.; Harro, Clayton; Sack, David A.; Talaat, Kawsar R.; Gutierrez, Ramiro L.; DeNearing, Barbara; Brubaker, Jessica; Laird, Renee M.; Poly, Frederic; Maue, Alexander C.; Jaep, Kayla; Alcala, Ashley; Mochalova, Yelizaveta; Gariepy, Christina L.; Chakraborty, Subhra; Guerry, Patricia; Tribble, David R.; Porter, Chad K.; Riddle, Mark S.
Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial
JOURNAL OF INFECTIOUS DISEASES
IF4.5
2017-05-2447
OAAI
Savarino, Stephen J.; McKenzie, Robin; Tribble, David R.; Porter, Chad K.; O'Dowd, Aisling; Cantrell, Joyce A.; Sincock, Stephanie A.; Poole, Steven T.; DeNearing, Barbara; Woods, Colleen M.; Kim, Hye; Grahek, Shannon L.; Brinkley, Carl; Crabb, Joseph H.; Bourgeois, A. Louis

研究方向

暂未获取到该数据
D
David A. Sack
H 指数:95论文数:585被引数:3.2万
C
Chad K. Porter
H 指数:41论文数:195被引数:4,868
A
A. Louis Bourgeois
H 指数:47论文数:145被引数:6,175
S
Subhra Chakraborty
H 指数:27论文数:82被引数:1,797
J
Jessica Brubaker
H 指数:13论文数:36被引数:653
K
Kawsar R. Talaat
H 指数:30论文数:92被引数:3,698
M
Mark S. Riddle
H 指数:56论文数:349被引数:1.2万
C
Clayton Harro
H 指数:34论文数:83被引数:3,603
B
Brittany Feijoo
H 指数:7论文数:14被引数:216
M
Michael G. Prouty
H 指数:17论文数:41被引数:1,128