未登录Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective
Vargas, Hugo M.; Rolf, Michael G.; Wisialowski, Todd A.; Achanzar, William; Bahinski, Anthony; Bass, Alan; Benson, Charles T.; Chaudhary, Khuram W.; Couvreur, Nicolas; Dota, Corina; Engwall, Michael J.; Michael Foley, C.; Gallacher, David; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Guth, Brian; Himmel, Herbert M.; Hegele-Hartung, Christa; Ito, Maki; Jenkinson, Stephen; Chiba, Katsuyoshi; Lagrutta, Armando; Levesque, Paul; Martel, Eric; Okai, Yoshiko; Peri, Ravikumar; Pointon, Amy; Qu, Yusheng; Teisman, Ard; Traebert, Martin; Yoshinaga, Takashi; Gintant, Gary A.; Leishman, Derek J.; Valentin, Jean-Pierre .png)
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收藏Characterization of a Novel Hafnium-Based X-ray Contrast AgentFrenzel, Thomas; Bauser, Marcus; Berger, Markus; Hilger, Christoph Stephan; Hegele-Hartung, Christa; Jost, Gregor; Neis, Christian; Hegetschweiler, Kaspar; Riefke, Bjoern; Suelzle, Detlev; Pietsch, Hubertus 分享 收藏 Preclinical evaluation of BAY 1075553, a novel 18F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancerLesche, Ralf; Kettschau, Georg; Gromov, Alexey V.; Boehnke, Niels; Borkowski, Sandra; Moenning, Ursula; Hegele-Hartung, Christa; Doehr, Olaf; Dinkelborg, Ludger M.; Graham, Keith 分享 收藏 Ligand-dependent activation of ERβ lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive ratsEr β 的配体依赖性激活可降低去卵巢自发性高血压大鼠的血压并减轻心肌肥厚Jazbutyte, Virginija; Arias-Loza, Paula Anahi; Hu, Kai; Widder, Julian; Govindaraj, Vijayakumar; von Poser-Klein, Christine; Bauersachs, Johann; Fritzemeier, Karl-Heinrich; Hegele-Hartung, Christa; Neyses, Ludwig; Ertl, Georg; Pelzer, Theo 分享 收藏 Both estrogen receptor subtypes, α and β, attenuate cardiovascular remodeling in aldosterone salt-treated ratsArias-Loza, Paula-Anahi; Hu, Kai; Dienesch, Charlotte; Mehlich, Anna Maria; Koenig, Simone; Jazbutyte, Virginia; Neyses, Ludwig; Hegele-Hartung, Christa; Fritzemeier, Karl Heinrich; Pelzer, Theo 分享 收藏 分享 收藏 Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17β-estradiol in aldosterone salt-treated ratsArias-Loza, Paula Anahi; Hu, Kai; Schaefer, Andreas; Bauersachs, Johann; Quaschning, Thomas; Galle, Jan; Jazbutyte, Virginija; Neyses, Ludwig; Ertl, Georg; Fritzemeier, Karl-Heinrich; Hegele-Hartung, Christa; Pelzer, Theo 分享 收藏 Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive ratsJazbutyte, Virginija; Hu, Kai; Kruchten, Patricia; Bey, Emmanuel; Maier, Sebastian K. G.; Fritzemeier, Karl-Heinrich; Prelle, Kaija; Hegele-Hartung, Christa; Hartmann, Rolf W.; Neyses, Ludwig; Ertl, Georg; Pelzer, Theo 分享 收藏 Selective activation of estrogen receptor-α or -β attenuates cardiac hypertrophy and fibrosis in aldosterone-salt treated rats;: a proteomic approach to identify specific target genes for ER-α and ER-β by 2D-DIGE and MALDI-TOFLoza, Paula-Anahi Arias; Hu, Kai; Neyses, Ludwig; Hegele-Hartung, Christa; Fritzemeier, Karl Heinrich; Dienesch, Charlotte; Koenig, Simone; Mehlich, Anna Maria; Jazbutyte, Virginia; Pelzer, Theo 分享 收藏 Medroxyprogesterone-acetate but not drospirenone ablates the protective function of 17b-estradiol against cardiovascular injury in aldosterone-treated ratsArias-Loza, Paula Anahi; Hu, Kai; Schaefer, Andreas; Bauersachs, Johann; Quaschning, Thomas; Galle, Jan; Neyses, Ludwig; Ertl, Georg; Fritzemeier, Karl-Heinrich; Hegele-Hartung, Christa; Pelzer, Theo 分享 收藏 The estrogen receptor-α agonist 16α-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats雌激素受体-α 激动剂16α-le2抑制雌激素缺乏的自发性高血压大鼠的心肌肥厚并改善血流动力学功能Pelzer, T; Jazbutyte, V; Hu, K; Segerer, S; Nahrendorf, M; Nordbeck, P; Bonz, AW; Muck, J; Fritzemeier, KH; Hegele-Hartung, C; Ertl, G; Neyses, L 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Identification of selective estrogen receptor modulators by their gene expression fingerprintsZajchowski, DA; Kauser, K; Zhu, DG; Webster, L; Aberle, S; White, FA; Liu, HL; Humm, R; MacRobbie, J; Ponte, P; Hegele-Hartung, C; Knauthe, R; Fritzemeier, KH; Vergona, R; Rubanyi, GM 分享 收藏 分享 收藏 
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