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AFVT-2101: A FRα x CD16A bispecific innate cell engager for the treatment of solid tumors Rigamonti, Nicolo'; Schmollinger, Jan; Sandy, Peter; Tomaszowski, Michael; Caslavsky, Josef; Trad, Ahmad; O'Shannessy, Daniel; Siegler, Jana; Gaukel, Eric J.; Penston, Daniela; Reusch, Uwe; Johnson, Zoe 分享 收藏
Preclinical safety & pharmacokinetics of AFVT-2101, a tetravalent FRα x CD16A bispecific innate cell engager for the treatment of solid tumors Luo, Wendy; Gaukel, Eric J.; Lansita, Janice A.; Laczko, Stephen M.; Sandy, Peter; O'Shannessy, Daniel J.; Penugonda, Sudhir; Manocha, Bhavik; Patterson, Daniel E.; Penugonda, Sudhir; Manocha, Bhavik; Patterson, Daniel E.; Kozlowska, Izabela; Sarlang, Severine; Knackmuss, Stefan; Penston, Daniela; Reusch, Uwe; Johnson, Zoe 分享 收藏
AFVT-2101, AN INNATE IMMUNE-CELL ENGAGER THAT SELECTIVELY TARGETS FOLR1 EXPRESSING TUMOR CELLS TO SAFELY HARNESS POTENT ANTI-CANCER RESPONSES Trad, Ahmad; Tomaszowski, Michael; Caslavsky, Josef; Freitag, Robert; Haan, Keith; Rohrwild, Markus; O'Shannessy, Daniel; Siegler, Jana; Penugonda, Sudhir; Sandy, Peter; Gaukel, Eric; Penston, Daniela; Johnson, Zoe 分享 收藏
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Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation Petrus, Paul; Fernandez, Tara L.; Kwon, Michelle M.; Huang, Jenny L.; Lei, Victor; Safikhan, Nooshin Seyed; Karunakaran, Subashini; O'Shannessy, Daniel J.; Zheng, Xiaowei; Catrina, Sergiu-Bogdan; Albone, Earl; Laine, Jukka; Virtanen, Kirsi; Clee, Susanne M.; Kieffer, Timothy J.; Noll, Christophe; Carpentier, Andre C.; Johnson, James D.; Ryden, Mikael; Conway, Edward M. 分享 收藏
A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer Grothey, Axel; Strosberg, Jonathan R.; Renfro, Lindsay A.; Hurwitz, Herbert I.; Marshall, John L.; Safran, Howard; Guarino, Michael J.; Kim, George P.; Hecht, J. R.; Weil, Susan C.; Heyburn, John; Wang, Wenquan; Schweizer, Charles; O'Shannessy, Daniel J.; Diaz, Luis Alberto, Jr. 分享 收藏
A phase 2 study of ontuxizumab, a monoclonal antibody targeting endosialin, in metastatic melanoma D'Angelo, Sandra P.; Hamid, Omid A.; Tarhini, Ahmad; Schadendorf, Dirk; Chmielowski, Bartosz; Collichio, Frances A.; Pavlick, Anna C.; Lewis, Karl D.; Weil, Susan C.; Heyburn, John; Schweizer, Charles; O'Shannessy, Daniel J.; Carvajal, Richard D. 分享 收藏
Comprehensive genomic characterization of a large cohort of platinum-sensitive, high-grade serous ovarian cancer (HGSOC) FFPE specimens Haynes, Brian C.; Fahey, Marie E.; Myers, Darcy; Ilsley, Diane; Latham, Gary J.; Somers, Elizabeth B.; Nicolaides, Nicholas C.; Schweizer, Charles; O'Shannessy, Daniel J. 分享 收藏
Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer O'Shannessy, Daniel J.; Bendas, Katie; Schweizer, Charles; Wang, Wenquan; Albone, Earl; Somers, Elizabeth B.; Weil, Susan; Meredith, Rhonda K.; Wustner, Jason; Grasso, Luigi; Landers, Mark; Nicolaides, Nicholas C. 分享 收藏
Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression Kurosaki, Akira; Hasegawa, Kosei; Kato, Tomomi; Abe, Kenji; Hanaoka, Tatsuya; Miyara, Akiko; O'Shannessy, Daniel J.; Somers, Elizabeth B.; Yasuda, Masanori; Sekino, Tetsuo; Fujiwara, Keiichi 分享 收藏
A First-in-Human Phase I Study of MORAb-004, a Monoclonal Antibody to Endosialin in Patients with Advanced Solid Tumors Diaz, Luis A., Jr.; Coughlin, Christina M.; Weil, Susan C.; Fishel, Jean; Gounder, Mrinal M.; Lawrence, Susan; Azad, Nilofer; O'Shannessy, Daniel J.; Grasso, Luigi; Wustner, Jason; Ebel, Wolfgang; Carvajal, Richard D. 分享 收藏
Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma Amatuximab的II期临床试验，一种嵌合的抗甲素抗体与培美曲塞和顺铂治疗晚期不可切除的胸膜间皮瘤 Hassan, Raffit; Kindler, Hedy L.; Jahan, Thierry; Bazhenova, Lyudmila; Reck, Martin; Thomas, Anish; Pastan, Ira; Parno, Jeff; O'Shannessy, Daniel J.; Fatato, Penny; Maltzman, Julia D.; Wallin, Bruce A. 分享 收藏
Clinical and Pathologic Characterization of Folate Receptor Alpha, Mesothelin, and Endosialin Expression in Mesotheliomas Owonikoko, T. K.; Busari, A.; Chen, Z.; Kim, S.; Alexis, D.; Somers, E. B.; O'Shannessy, D. J.; Ramalingam, S.; Khuri, F.; Sica, G. L. 分享 收藏
Assessment of Folate Receptor-α and Epidermal Growth Factor Receptor Expression in Pemetrexed-Treated Non-Small-Cell Lung Cancer Patients Christoph, Daniel C.; Reyna-Asuncion, Bernadette; Hassan, Biftu; Tran, Cindy; Maltzman, Julia D.; O'Shannessy, Daniel J.; Gauler, Thomas C.; Wohlschlaeger, Jeremias; Schuler, Martin; Eberhardt, Wilfried E.; Hirsch, Fred R. 分享 收藏
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Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils White, JR; Imburgia, C; Dul, E; Appelbaum, E; ODonnell, K; OShannessy, DJ; Brawner, M; Fornwald, J; Adamou, J; Elshourbagy, NA; Kaiser, K; Foley, JJ; Schmidt, DB; Johanson, K; Macphee, C; Moores, K; McNulty, D; Scott, GF; Schleimer, RP; Sarau, HM 分享 收藏
Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B Berkhout, TA; Sarau, HM; Moores, K; White, JR; Elshourbagy, N; Appelbaum, E; Reape, TJ; Brawner, M; Makwana, J; Foley, JJ; Schmidt, DB; Imburgia, C; McNulty, D; Matthews, J; ODonnell, K; OShannessy, D; Scott, M; Groot, PHE; Macphee, C 分享 收藏
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