Mary T. Obermeier

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis

IF6.8

2026-01-010

PRE

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313

IF4

2021-04-306

Liu, Qingjie; Xiao, Hai-Yun; Batt, Douglas G.; Xiao, Zili; Zhu, Yeheng; Yang, Michael G.; Li, Ning; Yip, Shiuhang; Li, Peng; Sun, Dawn; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John S.; Weigelt, Carolyn A.; Wang, Jinhong; Li, Sha; Shuster, David J.; Xie, Jenny H.; Song, Yunling; Sherry, Tara; Obermeier, Mary T.; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Chacko, Silvi; Khandelwal, Purnima; Dudhgaonkar, Shailesh; Rudra, Anjuman; Nagar, Jignesh; Murali, Venkata; Govindarajan, Arun; Denton, Rex; Zhao, Qihong; Meanwell, Nicholas A.; Borzilleri, Robert; Dhar, T. G. Murali

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

IF6.8

2021-02-1612

PREAI

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

IF4

2020-11-0617

OAAI

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

IF4

2020-09-165

OAAI

Srivastava, Anurag S.; Ko, Soo; Watterson, Scott H.; Pattoli, Mark A.; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T.; Vickery, Rodney; Discenza, Lorell N.; D'Arienzo, Celia J.; Gillooly, Kathleen M.; Taylor, Tracy L.; Pulicicchio, Claudine; McIntyre, Kim W.; Yip, Shiuhang; Li, Peng; Sun, Dawn; Wu, Dauh-Rurng; Dai, Jun; Wang, Chunlei; Zhang, Yingru; Wang, Bei; Pawluczyk, Joseph; Kempson, James; Zhao, Rulin; Hou, Xiaoping; Rampulla, Richard; Mathur, Arvind; Galella, Michael A.; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Fura, Aberra; Burke, James R.; Tino, Joseph A.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

IF4

2020-03-3137

OAAI

Cherney, Robert J.; Cornelius, Lyndon A. M.; Srivastava, Anurag; Weigelt, Carolyn A.; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G.; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhar, T. G. Murali

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)

IF6.8

2019-10-2233

PREAI

Marcoux, David; Duan, James J. -W.; Shi, Qing; Cherney, Robert J.; Srivastava, Anurag S.; Cornelius, Lyndon; Batt, Douglas G.; Liu, Qingjie; Beaudoin-Bertrand, Myra; Weigelt, Carolyn A.; Khandelwal, Purnima; Vishwakrishnan, Sureshbabu; Selvakumar, Kumaravel; Karmakar, Ananta; Gupta, Arun Kumar; Basha, Mushkin; Ramlingam, Sridharan; Manjunath, Naveen; Vanteru, Sridhar; Karmakar, Sukhen; Maddala, Nageswara; Vetrichelvan, Muthalagu; Gupta, Anuradha; Rainpulla, Richard A.; Mathur, Arvind; Yip, Shiuhang; Li, Peng; Wu, Dauh-Rurng; Khan, Javed; Ruzanov, Max; Sack, John S.; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Li, Sha; Shuster, David J.; Borowski, Virna; Xie, Jenny H.; McIntyre, Kim W.; Obermeier, Mary T.; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Hynes, John, Jr.; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhare, T. G. Murali

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (P13Kδ) Inhibitor for the Treatment of Immunological Disorders

IF6.8

2019-03-2086

OAAI

Watterson, Scott H.; Liu, Qingjie; Bertrand, Myra Beaudoin; Batt, Douglas G.; Li, Ling; Pattoli, Mark A.; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T.; Moore, Robin; Yang, Zheng; Vickery, Rodney; Elzinga, Paul A.; Discenza, Lorell; D'Arienzo, Celia; Gillooly, Kathleen M.; Taylor, Tracy L.; Pulicicchio, Claudine; Zhang, Yifan; Heimrich, Elizabeth; McIntyre, Kim W.; Ruan, Qian; Westhouse, Richard A.; Catlett, Ian M.; Zheng, Naiyu; Chaudhry, Charu; Dai, Jun; Galella, Michael A.; Tebben, Andrew J.; Pokross, Matt; Li, Jianqing; Zhao, Rulin; Smith, Daniel; Rampulla, Richard; Allentoff, Alban; Wallace, Michael A.; Mathur, Arvind; Salter-Cid, Luisa; Macor, John E.; Carter, Percy H.; Fura, Aberra; Burke, James R.; Tino, Joseph A.

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase

IF6.8

2017-06-0517

PREAI

Liu, Qingjie; Shi, Qing; Marcoux, David; Batt, Douglas G.; Cornelius, Lyndon; Qin, Lan-Ying; Ruan, Zheming; Neels, James; Beaudoin-Bertrand, Myra; Srivastava, Anurag S.; Li, Ling; Cherney, Robert J.; Gong, Hua; Watterson, Scott H.; Weigelt, Carolyn; Gillooly, Kathleen M.; McIntyre, Kim W.; Xie, Jenny H.; Obermeier, Mary T.; Fura, Aberra; Sleczka, Bogdan; Stefanski, Kevin; Fancher, R. M.; Padmanabhan, Shweta; Thatipamula, R. P.; Kundu, Ipsit; Rajareddy, Kallem; Smith, Rodney; Herman, James K.; Xing, Dezhi; Fan, Jingsong; Levesque, Paul C.; Ruan, Qian; Pitt, Sidney; Zhang, Rosemary; Pedicord, Donna; Pan, Jie; Yarde, Melissa; Lu, Hao; Lippy, Jonathan; Goldstine, Christine; Skala, Stacey; Rampulla, Richard A.; Mathur, Arvind; Gupta, Anuradha; Arunachalam, Pirama Nayagam; Sack, John S.; Muckelbauer, Jodi K.; Cvijic, Mary Ellen; Salter-Cid, Luisa M.; Bhide, Rajeev S.; Poss, Michael A.; Hynes, John; Carter, Percy H.; Macor, John E.; Ruepp, Stefan; Schieven, Gary L.; Tino, Joseph A.

JOURNAL OF CHROMATOGRAPHY A

IF4

2017-03-0119

PREAI

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)

IF6.8

2016-09-19117

PREAI

Watterson, Scott H.; De Lucca, George V.; Shi, Qing; Langevine, Charles M.; Liu, Qingjie; Batt, Douglas G.; Bertrand, Myra Beaudoin; Gong, Hua; Dai, Jun; Yip, Shiuhang; Li, Peng; Sun, Dawn; Wu, Dauh-Rurng; Wang, Chunlei; Zhang, Yingru; Traeger, Sarah C.; Pattoli, Mark A.; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T.; Vickery, Rodney; Discenza, Lorell N.; D'Arienzo, Celia J.; Zhang, Yifan; Heimrich, Elizabeth; Gillooly, Kathleen M.; Taylor, Tracy L.; Pulicicchio, Claudine; McIntyre, Kim W.; Galena, Michael A.; Tebben, Andy J.; Muckelbauer, Jodi K.; Chang, ChiehYing; Rampulla, Richard; Mathur, Arvind; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Fura, Aberra; Burke, James R.; Tino, Joseph A.

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

IF6.8

2016-08-2655

PREAI

De Lucca, George V.; Shi, Qing; Liu, Qingjie; Batt, Douglas G.; Bertrand, Myra Beaudoin; Rampulla, Rick; Mathur, Arvind; Discenza, Lorell; D'Arienzo, Celia; Dai, Jun; Obermeier, Mary; Vickery, Rodney; Zhang, Yingru; Yang, Zheng; Marathe, Punit; Tebben, Andrew J.; Muckelbauer, Jodi K.; Chang, ChiehYing J.; Zhang, Huiping; Gillooly, Kathleen; Taylor, Tracy; Pattoli, Mark A.; Skala, Stacey; Kukral, Daniel W.; McIntyre, Kim W.; Salter-Cid, Luisa; Fura, Aberra; Burke, James R.; Banish, Joel C.; Carter, Percy H.; Tino, Joseph A.

用于治疗前列腺癌的选择性CYP17A1裂解酶抑制剂BMS-351的发现

Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

IF4

2015-12-147

OAAI

The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity

IF16.6

2015-08-011

PRE

The Discovery of Potent and Selective Inhibitors of CYP17 Lyase

IF16.6

2015-08-010

PRE

EUROPEAN JOURNAL OF CANCER

IF7.1

2012-11-010

PREAI

Phase I Dose-Escalation Study of the Novel Antiandrogen BMS-641988 in Patients with Castration-Resistant Prostate Cancer

CLINICAL CANCER RESEARCH

IF10.2

2011-02-1535

OAAI

Androgen receptor antagonists: Lead optimization and preclinical pharmacology

Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer

IF16.6

2010-04-010

PRE

Gavai, Ashvin; Norris, Derek; Balog, Aaron; Austin, Joel; Shan, Weifang; Zhao, Yufen; Han, Wen-Ching; Sharma, Lisa; Nation, Andrew; Wu, Dauh-Rurng; Mathur, Arvind; Zhang, Litai; Cvijic, Mary Ellen; Yarde, Melissa; Apanovitch, Donald; Twamley, Celeste; Tang, Yuwei; Johnson, Benjamin; Elzinga, Paul; Cornelius, Georgia; Obermeier, Mary; Foster, William; Marathe, Punit; Dell-John, Janet; Dito, Gennaro; Masters, Gregg; Rizzo, Cheryl; Schweizer, Liang; Jure-Kunkel, Maria; Attar, Ricardo; Gottardis, Marco; Vite, Gregory

Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

IF16.6

2009-08-1252

OAAI