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Arvind Mathur

Bristol Myers Squibb
H指数:32
被引数:3,506

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Discovery of BMS-159; an Orally Active Imidazotriazine Pan-CK2 Inhibitor for the Treatment of Cancer

BMS-159的发现；一种口服活性的咪唑三嗪泛CK2抑制剂用于癌症治疗

ACS Medicinal Chemistry Letters
IF4
2026-04-220
PRE
Christine M. Tarby; Amy Hart; Honghe Wan; Liqi He; John Tokarski; Brian Fink; Yufen Zhao; Tram Huynh; Ashvinikumar Gavai; Kurt Zimmermann; Gregory Vite; Dolatrai Vyas; Jennifer Inghrim; Mary Obermeier; Aberra Fura; Paul Elzinga; John Hunt; Urvashi Roongta; Benjamin Henley; Jonathan Lippy; Arvind Mathur; Dauh Rurng Wu; Peng Li; Nirmala Raghavan; Gerry Everlof; Brent Rupnow; Francis Lee; Joseph Fargnoli; Jeffrey Tredup; Susan E. Kiefer; Deepa Calambur; Anuradha Gupta; Muthalagu Vetrichelvan; Murugaiah A. M. Subbaiah; Ashok V. Purandare
From Flat to 3D: Replacing Phenyl Rings with Saturated Bridged Bicyclic Mimetics to Mitigate Bioactivation and Optimize ADME Properties and Oral Bioavailability in Reverse Amide Orientation

从平面到3D：用饱和桥环双环拟肽取代苯环以降低生物活化并优化反向酰胺取向的ADME性质和口服生物利用度

Journal of Medicinal Chemistry
IF6.8
2026-03-300
PRE
Murugaiah A. M. Subbaiah; Shruti Surendran; Gaurav Saini; Lavanya Billava Ramappa; Sivashankaran Raju; Joyson Nandha; Himangshu Bhowmik; Enugurthi Krishna; Sushmita Janrao; Vijay Kumar; Shruti Shikha Choubey; Joothipriya Subramanian; Bhuvaneshwaran Anandamoorthy; Sukanta Kumar Sahoo; Raghavendra Veerapuram; Korlepara Vamsi Krishna; Manohar Yelleswarapu; Yogesh Kumar Gupta; Muthalagu Vetrichelvan; Anuradha Gupta; Salil Desai; Thanga Mariappan; Arvind Mathur; Prakash Ramaseshan Vachaspati
Desymmetrization of meso-Anhydride Enabled Enantioselective Synthesis of (−)-7-(Bromomethylene)-3-amidobicyclo[2.2.1]heptane-2-carboxamide; a Scaffold for Divergent Drug Discovery Synthesis

meso-酐的不对称破坏实现 (−)-7-(溴亚甲基)-3-氨基硫杂双环[2.2.1]庚烷-2-甲酰胺的对映选择性合成；一种用于发散式药物发现合成的骨架

The Journal of Organic Chemistry
IF3.6
2025-12-030
PRE
Jianqing Li; Subramaniam Krishnananthan; Daniel Smith; Chetan Padmakar Darne; Ning Li; Lyndon Cornelius; Bei Wang; Rulin Zhao; Peng Li; Dauh-Rurng Wu; James Kempson; Sarah C. Traeger; Michael A. Galella; Amy Sarjeant; Shun Su; Roshan Y. Nimje; Yoganand Shanmugam; Dyamanna Doddalingappa; Rajesh Krishnan; Anuradha Gupta; Arvind Mathur
Beyond Bioisosteres: Impact of Replacing a Benzene Ring with sp3-Rich Three-Dimensional Saturated Bridged Bicyclic Match Pairs on Biotransformation; Metabolic Stability; and Other ADME Profiles

超越生物电子等排体：用sp3-富集的三维饱和桥环双环匹配对替换苯环对生物转化、代谢稳定性及其他ADME特性的影响

Journal of Medicinal Chemistry
IF6.8
2025-10-010
PRE
Shruti Surendran; Sivashankaran Raju; Naveen Kalyani; Gaurav Saini; Joyson Nandha; Himangshu Bhowmik; Anil Rathod; Shruti Shikha Choubey; Bhuvaneshwaran Anandamoorthy; Sukanta Kumar Sahoo; Yogesh Kumar Gupta; Muthalagu Vetrichelvan; Anuradha Gupta; Salil Desai; Thanga Mariappan; Arvind Mathur; Prakash Ramaseshan Vachaspati; Murugaiah A. M. Subbaiah
Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl) benzamides for the treatment of metabolic disorders

肝选择性葡萄糖激酶激活剂的发现，包括N-(4-烷基硫唑-2-基)苯甲酰胺和N-(3-烷基-1,2,4-噻二唑-5-基)苯甲酰胺，用于治疗代谢紊乱

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
2025-07-010
PRE
Yoon, David S.; Wu, Shung; Chen, Sean S.; Smirk, Rebecca A.; Brigance, Robert P.; Meng, Wei; Shi, Yan; Tao, Shiwei; Wang, Ying; Zhang, Hao; Mathur, Arvind; Catanio, Helen Grace; Kalinowski, Stephen; Zebo, Rachel; Zalaznick, Jacob; Taylor, Joseph; Zinker, Bradley; Kopcho, Lisa M.; Behnia, Kamelia; Xu, Carrie; Spronk, Steven A.; Yang, Yanou; Josephs, Jonathan; Janovitz, Evan B.; Marathe, Punit; Whaley, Jean; Barrish, Joel C.; Kirby, Mark; Cheng, Peter T. W.
The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists

C7-取代降冰片基双酰胺类化合物作为RXFP1小分子激动剂的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-280
PRE
Su, Shun; Myers, Michael C.; Bilder, Donna M.; Clarke, Adam; Friends, Todd; Petrone, Thomas V.; Ryan, Carol; Krause, Carol M.; Chen, Ruihua; Li, Yi-xin; Fronheiser, Matthew; Galella, Michael A.; Rose, Anne V.; Generaux, Claudia N.; Zhao, Lei; Bostwick, Jeff; Li, Jianqing; Mathur, Arvind; Duclos, Franck; Madsen, Cort S.; Wexler, Ruth R.; Lawrence, R. Michael
Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity

发现并表征了一种具有强效髓系细胞激活和抗肿瘤活性的首创LIV1-TLR7/8免疫调节偶联物

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-240
OA
Yamazoe, Sayumi; Poudel, Yam; Sega, Emanuela; Mukhopadhyay, Anandaroop; Ramakrishnan, Radha; Ukairo, Okechukwu; Liu, Scot; Akter, Rahima; Sadanala, Keerthi; Que, Kathryn; Cheng, Qinqin; Kotapati, Srikanth; Deshpande, Madhura; Cox, Matthew; Chourey, Shishir; Gupta, Anuradha; Kempson, James; Pabbisetty, Kumar; Kaspady, Mahammed; Bhattasali, Debabrata; Yip, Shiuhang; Wu, Dauh-Rurng; Pookot, Deepa; Li, Yvonne; Kozhich, Alexander; Drexler, Dieter; Carl, Stephen; Deyanova, Ekaterina; Smith, Michael; Chan, Henry; West, Sean; Diong, S. J.; Chang, Aram; Florin, Lore; Mathur, Arvind; Strop, Pavel; Zapf, Christoph W.; Law, Deborah; Wilson, Nicholas; Broz, Miranda; Chekler, Eugene P.
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-12-190
PRE
Poudel, Yam B.; Lo, Julian C.; Norris, Derek J.; Cox, Matthew; He, Liqi; Johnson, Walter L.; Subbaiah, Murugaiah A. M.; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R.; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V.; Mathur, Arvind; Zapf, Christoph W.; Chekler, Eugene P.
Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-050
PRE
Yoon, David S.; Liu, Chunjian; Jalagam, Prasada Rao; Feng, Jianxin; Wang, Wei; Swidorski, Jacob J.; Xu, Li; Hartz, Richard A.; Nair, Satheesh K.; Beno, Brett R.; Panda, Manoranjan; Ghosh, Kaushik; Kumar, Amit; Sale, Harinath; Shah, Devang; Mathur, Arvind; Ellsworth, Bruce A.; Cheng, Dong; Regueiro-Ren, Alicia
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-05-292
PRE
Richter, Jeremy M.; Gunaga, Prashantha; Yadav, Navnath; Bora, Rajesh Onkardas; Bhide, Rajeev; Rajugowda, Nagendra; Govindrajulu, Kavitha; Godesi, Sreenivasulu; Akuthota, Nagarjuna; Rao, Prasanna; Sivaraman, Aneesh; Panda, Manoranjan; Kaspady, Mahammed; Gupta, Anuradha; Mathur, Arvind; Levesque, Paul C.; Gulia, Jyoti; Dokania, Manoj; Ramarao, Manjunath; Kole, Prashant; Chacko, Silvi; Lentz, Kimberley A.; Sivaprasad Lvj, Sankara; Thatipamula, Rajendra Prasad; Sridhar, Srikanth; Kamble, Shyam; Govindrajan, Arun; Soleman, Sharif I.; Gordon, David A.; Wexler, Ruth R.; Priestley, E. Scott
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)
JOURNAL OF ORGANIC CHEMISTRY
IF3.6
2024-04-234
PRE
Kempson, James; Zhao, Rulin; Pawluczyk, Joseph; Wang, Bei; Zhang, Huiping; Hou, Xiaoping; Allen, Martin P.; Wu, Dauh-Rurng; Li, Peng; Yip, Shiuhang; Smith, Aaron; Traeger, Sarah C.; Huang, Stella; Cutrone, Jingfang; Mukherjee, Subha; Sfouggatakis, Chris; Poss, Michael; Scola, Paul M.; Meanwell, Nicholas A.; Carter, Percy H.; Mathur, Arvind
Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S⋅⋅⋅O binding interaction for drug design
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2024-03-011
PRE
Liu, Chunjian; Wang, Wei; Feng, Jianxin; Beno, Brett; Raja, Thiruvenkadam; Swidorski, Jacob; Manepalli, Raju K. V. L. P.; Vetrichelvan, Muthalagu; Jalagam, Prasada Rao; Nair, Satheesh K.; Gupta, Anuradha; Panda, Manoranjan; Ghosh, Kaushik; Shukla, Jinal Kaushikkumar; Sale, Harinath; Shah, Devang; Gautam, Shashyendra Singh; Patel, Dipal; Mathur, Arvind; Ellsworth, Bruce A.; Cheng, Dong; Regueiro-Ren, Alicia
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-01-092
PRE
He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F.; Zhang, Yong; Tarby, Christine; Gill, Patrice; Subbaiah, Murugaiah A. M.; Ramar, Thangeswaran; Reddy, Maheswara; Puttapaka, Vijaya; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Murtaza, Anwar; Oderinde, Martins S.; Schieven, Gary L.; Mathur, Arvind; Gavai, Ashvinikumar V.; Vite, Gregory; Gangwar, Sanjeev; Poudel, Yam B.
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-01-083
PRE
Poudel, Yam B.; He, Liqi; Cox, Matthew; Zhang, Qian; Johnson, Walter L.; Cong, Qiang; Cheng, Heng; Chowdari, Naidu S.; Tarby, Christine; Donnell, Andrew F.; Broekema, Matthais; O'Malley, Daniel P.; Zhang, Yong; Subbaiah, Murugaiah A. M.; Kumar, Boda Vijay; Subramani, Lakshumanan; Wang, Bei; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Sandhu, Bhupindar; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Oderinde, Martins S.; Murtaza, Anwar; Schieven, Gary L.; Mathur, Arvind; Gavai, Ashvinikumar V.; Vite, Gregory; Gangwar, Sanjeev

研究方向

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Dauh‐Rurng Wu
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Anuradha Gupta
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James Kempson
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Richard Rampulla
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Jianqing Li
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Dawn Sun
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P
Percy H. Carter
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M
Mary Ellen Cvijic
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T. G. Murali Dhar
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