未登录 RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia RSK1是骨髓增殖性肿瘤和继发性急性髓系白血病的一个可利用的依赖性。 Kong, Tim; Laranjeira, Angelo B. A.; Letson, Christopher T.; Yu, Layow; Lin, Shuyang; Fowles, Jared S.; Fisher, Daniel A. C.; Ng, Sherwin; Yang, Wei; He, Fan; Youn, Minyoung; Mark, Kailen; Jose, Ana San; Liu, Jingxian; Kim, Alexander B.; Cox, Maggie J.; Fulbright, Mary C.; Jayanthan, Aarthi; Los, Gerrit; Rentschler, Stacey L.; Ding, Li; Sakamoto, Kathleen M.; Dunn, Sandra E.; Challen, Grant A.; Oh, Stephen T. 分享 收藏
RSK1 dependency in FLT3-ITD acute myeloid leukemia Kong, Tim; Laranjeira, Angelo B. A.; Letson, Christopher T.; Yu, Layow; He, Fan; Jayanthan, Aarthi; Los, Gerrit; Dunn, Sandra E.; Challen, Grant A.; Oh, Stephen T. 分享 收藏
Patient selection for high RSK2 expression is key for achieving improved PFS in metastatic breast cancer in the PMD-026 Phase 1/ 1b study Dunn, Sandra; Wang, Judy; Han, Hyo; Wesolowski, Robert; Patnaik, Amita; Bahadur, Shakeela; Palaskas, Nicolaos; Huynh, My-My; Jayanthan, Aarthi; Los, Gerrit; Dorr, Andrew 分享 收藏
High levels of RSK2 in breast cancer patients is associated with longer PFS in patients treated with PMD-026, a first in class RSK inhibitor Wang, Judy S.; Beeram, Muralidhar; Chalasani, Pavani; Mina, Lida; Shatsky, Rebecca A.; Hurvitz, Sara; Trivedi, Meghna S.; Wesolowski, Robert; Han, Hyo S.; Patnaik, Amita; Bahadur, Shakeela; Huynh, My-My; Jayanthan, Aarthi; Los, Gerrit; Dunn, Sandra E.; Dorr, Andrew 分享 收藏
First-in-human expansion study of oral PMD-026 in metastatic triple negative breast cancer patients Beeram, Muralidhar; Wang, Judy S.; Mina, Lida A.; Chalasani, Pavani; Shatsky, Rebecca A.; Wesolowski, Robert; Hurvitz, Sara A.; Trivedi, Meghna S.; Han, Hyo S.; Patnaik, Amita; Huynh, My-my; Jayanthan, Aarthi; Pambid, Mary Rose; Yue, Lambert; Los, Gerrit; Dunn, Sandra E.; Dorr, Andrew 分享 收藏
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RETRACTION: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells (Retraction of Vol 300, Pg 30, 2011) Mehta, Pramod P.; Kung, Pei-Pei; Yamazaki, Shinji; Walls, Marlena; Shen, Andrea; Nguyen, Leslie; Gehring, Michael R.; Los, Gerrit; Smeal, Tod; Yin, Min-Jean 分享 收藏
Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621 Michaud, Neil R.; Jani, Jitesh P.; Hillerman, Stephen; Tsaparikos, Konstantinos E.; Barbacci-Tobin, Elsa G.; Knauth, Elisabeth; Putz, Henry, Jr.; Campbell, Mary; Karam, George A.; Chrunyk, Boris; Gebhard, David F.; Green, Larry L.; Xu, Jinghai J.; Dunn, Margaret C.; Coskran, Tim M.; Lapointe, Jean-Martin; Cohen, Bruce D.; Coleman, Kevin G.; Bedian, Vahe; Vincent, Patrick; Kajiji, Shama; Steyn, Stefan J.; Borzillo, Gary V.; Los, Gerrit 分享 收藏
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Preclinical efficacy of targeting FGF autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230 De Young, M. Phillip; Sherk, Christian; Bleam, Maureen; Barnette, Mary; Ganji, Gopi; Hoang, Bao; Tunstead, James; Bellovin, David; Los, Gerrit; Minthorn, Elisabeth; Kumar, Rakesh 分享 收藏
FP-1039/GSK3052230, an FGF ligand trap, enhances VEGF antagonist therapy in preclinical models of RCC and HCC Bellovin, David I.; Palencia, Servando; Hestir, Kevin; Lee, Ernestine; DeYoung, M. Phillip; Brennan, Thomas; Los, Gerrit; Baker, Kevin 分享 收藏
Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules Murray, J.; Thomas, H.; Berry, P.; Kyle, S.; Patterson, M.; Jones, C.; Los, G.; Hostomsky, Z.; Plummer, E. R.; Boddy, A. V.; Curtin, N. J. 分享 收藏
Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line Fang, Douglas D.; Cao, Joan; Jani, Jitesh P.; Tsaparikos, Konstantinos; Blasina, Alessandra; Kornmann, Jill; Lira, Maruja E.; Wang, Jianying; Jirout, Zuzana; Bingham, Justin; Zhu, Zhou; Gu, Yin; Los, Gerrit; Hostomsky, Zdenek; VanArsdale, Todd 分享 收藏
Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian Cancer Ihnen, Maike; Eulenburg, Christine Zu; Kolarova, Teodora; Qi, Jing Wei; Manivong, Kanthinh; Chalukya, Meenal; Dering, Judy; Anderson, Lee; Ginther, Charles; Meuter, Alexandra; Winterhoff, Boris; Jones, Sian; Velculescu, Victor E.; Venkatesan, Natarajan; Rong, Hong-Mei; Dandekar, Sugandha; Udar, Nitin; Jaenicke, Fritz; Los, Gerrit; Slamon, Dennis J.; Konecny, Gottfried E. 分享 收藏
A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo Kuruma, Hidetoshi; Matsumoto, Hiroaki; Shiota, Masaki; Bishop, Jennifer; Lamoureux, Francois; Thomas, Christian; Briere, David; Los, Gerrit; Gleave, Martin; Fanjul, Andrea; Zoubeidi, Amina 分享 收藏
Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor Zou, Helen Y.; Li, Qiuhua; Lee, Joseph H.; Arango, Maria E.; Burgess, Kristina; Qiu, Ming; Engstrom, Lars D.; Yamazaki, Shinji; Parker, Max; Timofeevski, Sergei; Cui, Jingrong Jean; McTigue, Michele; Los, Gerrit; Bender, Steven L.; Smeal, Tod; Christensen, James G. 分享 收藏
Inhibition of Notch signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells Wei, Ping; Qiu, Ming; Jiang, Ivy; Carroll, Christopher; Han, Guangzhou; Rymer, Isha; Kraynov, Eugenia; Wu, Aidong; Thibault, Stephane; Stone, Donna; Gao, Yijie; Sofia, Susan; Gallo, Jorge; White, Janet; Li, Gary; Yang, Jennifer; Los, Gerrit 分享 收藏
A NOVEL ANTIANDROGEN PF-05234848 SUPPRESSES CASTRATION-RESISTANT AND MDV-3100-RESISTANT PROSTATE CANCER GROWTH IN VITRO AND IN VIVO Kuruma, Hidetoshi; Matsumoto, Hiroaki; Shiota, Masaki; Fanjul, Andrea; Briere, David; Los, Gerrit; Lamoureux, Francois; Thomas, Christian; Gleave, Martin; Zoubeidi, Amina 分享 收藏
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