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李丁 封面图

李丁 (Li Ding)

washington university in st louis教授，博士生导师
H指数:135
被引数:12.4万

个人简介

"简单介绍李丁，2009年由中山大学‘百人计划’引入中山大学药学院担任教授, 博士生导师。1989年北京大学化学系本科毕业，并于1995年在美国明尼苏达大学(University of Minnesota)化学系获博士学位。1995年到2000年在哈佛大学(Harvard University)化学系和德州农工大学(Texas A&M University)化学系担任研究助理和从事博士后研究工作。2000年到2009年在香港城市大学生物化学系先后担任助理教授和副教授。先后主持过十多项科研项目，其中包括3项国家自然科学基金项目、2项香港研究资助局科研项目、以及广东省和广州市科研项目。目前在高水平杂志上发表论文130多篇, 平均影响因子5.6。兼任教育部学位中心学位论文评议专家和广东省药学会药物化学专业委员会委员。曾获评优秀毕业论文指导教师。教授的课程包括化学生物学、药物化学，有机化学等。目前主要从事抗癌领域研究，包括小分子化合物通过调控基因启动子区域特殊DNA二级结构及其结合蛋白进而影响下游癌基因表达的分子机制、以小分子化合物为探针的端粒G-四链体及其结合蛋白Shelterin相互作用机制研究等。另外，还从事心血管疾病和老年痴呆症相关的一些分子机制研究。"

教育背景

  • 1990.08 – 1995.04

    美国明尼苏达大学 化学系 博士毕业 化学系

  • 1985.09 – 1989.08

    北京大学 化学系 本科毕业 化学系

工作经历

  • 2009.01 – 至今

    中山大学，药学院

    教授，博士生导师

  • 2002.01 – 2009.12

    香港城市大学，生物化学系

    副教授

  • 2000.01 – 2002.12

    香港城市大学，生物化学系

    助理教授

  • 1996.01 – 2000.12

    美国德州农工大学，化学系

    博士后

  • 1995.01 – 1996.12

    美国哈佛大学，化学系

    研究助理

  • 1990.01 – 1995.12

    美国明尼苏达大学，化学系

    研究和教学助理

荣誉奖项

  1. 优秀毕业论文指导教师
Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets

整合蛋白质组学和代谢组学分析急性髓系白血病以识别分子亚型及相关治疗靶点

Nature Cancer
IF28.5
2026-06-120
OA
Shih-Chun A. Chu; Yi Hsiao; Chenwei Wang; Jennifer E. Kyle; Raghav Jain; Yamei Deng; Marina A. Gritsenko; Leanne E. Henry; Jonathan T. Lei; Yongchao Dou; Bahar Tercan; Zhiao Shi; Mahnoor N. Gondal; Chia-Feng Tsai; John M. Elizarraras; Rosalie K. Chu; Fengchao Yu; Sunil K. Joshi; Xiaojun Jing; Daniel A. Polasky; Karl K. Weitz; Ginny Xiaohe Li; Vanessa L. Paurus; Chaevien S. Clendinen; Athena A. Schepmoes; Priscila M. Lalli; Josie G. Eder; Javier E. Flores; Kelly G. Stratton; James C. Pino; Camilo Posso; Vladislav A. Petyuk; Tyler J. Sagendorf; Yuanwei Xu; Omar M. Ibrahim; Ronald J. Moore; Rui Zhao; Jin Chen; Matthew E. Monroe; Mathangi Thiagarajan; Galen Hostetter; Chelsea Newton; Eunkyung An; Ana I. Robles; Xu Zhang; Nathan J. Edwards; Yin Lu; Hui Zhang; Haitham Abdelhakim; Paul D. Piehowski; Mehdi Mesri; Richard D. Smith; Chandan Kumar-Sinha; Cristina E. Tognon; Jennifer Dunlap; Elie Traer; Li Ding; Jeffrey W. Tyner; Arul M. Chinnaiyan; Gilbert S. Omenn; Karin D. Rodland; Saravana M. Dhanasekaran; Sara J. C. Gosline; Alexey I. Nesvizhiskii; Bing Zhang; Tao Liu; Marcin P. Cieslik
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial

palbociclib联合阿那曲唑治疗内分泌耐药雌激素受体阳性/HER2-negative乳腺癌新辅助治疗反应的生物标志物: 一项2期试验

Nature Communications
IF15.7
2026-01-270
OAAI
Tim Kong; Alex Mabry; Maureen Highkin; Anthony Z. Wang; Jeremy Hoog; Zhanfang Guo; Adrian Gonzales-Gonzales; Shana Thomas; Yingduo Song; Feng Gao; Mateusz Opyrchal; Lindsay Peterson; Foluso Ademuyiwa; Julie Margenthaler; Rebecca Aft; Katherine Glover-Collins; Leslie Nehring; Yu Tao; Souzan Sanati; Ian S. Hagemann; Fouad Boulos; Matthew Holt; Li Ding; Wenge Zhu; Stephen T. Oh; Jianxin Wang; Agnieszka K. Witkiewicz; Erik S. Knudsen; Ron Bose; Jason D. Weber; Matthew Goetz; Donald Northfelt; Jingqin Luo; Cynthia X. Ma
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

单细胞图谱表征与多发性骨髓瘤结局相关的骨髓免疫微环境失调

Nature Cancer
IF28.5
2026-01-090
OAAI
William C. Pilcher; Lijun Yao; Edgar Gonzalez-Kozlova; Yered Pita-Juarez; Dimitra Karagkouni; Chaitanya R. Acharya; Marina E. Michaud; Mark Hamilton; Shivani Nanda; Yizhe Song; Kazuhito Sato; Julia T. Wang; Sarthak Satpathy; Yuling Ma; Jessica Schulman; Darwin D’Souza; Reyka G. Jayasinghe; Denis Ohlstrom; Katherine E. Ferguson; Giulia Cheloni; Mojtaba Bakhtiari; Nick Pabustan; Kai Nie; Jennifer A. Foltz; Isabella Saldarriaga; Rania Alaaeldin; Eva Lepisto; Rachel Chen; Mark A. Fiala; Beena E. Thomas; April Cook; Junia Vieira Dos Santos; Chiang I-ling; Igor Figueiredo; Julie Fortier; Michael Slade; Stephen T. Oh; Michael P. Rettig; Emilie Anderson; Ying Li; Surendra Dasari; Michael A. Strausbauch; Vernadette A. Simon; Emir Radkevich; Adeeb H. Rahman; Zhihong Chen; Alessandro Lagana; John F. DiPersio; Jacalyn Rosenblatt; Seunghee Kim-Schulze; Sagar Lonial; Shaji Kumar; Swati S. Bhasin; Taxiarchis Kourelis; Madhav V. Dhodapkar; Ravi Vij; David Avigan; Hearn J. Cho; George Mulligan; Li Ding; Sacha Gnjatic; Ioannis S. Vlachos; Manoj Bhasin
Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis

新诊断多发性骨髓瘤中lncRNA表达的研究揭示了一个LINC01432-CELF2轴作为凋亡抑制剂

Oncogenesis
IF6.4
2025-10-060
OA
Richa Mishra; Prasanth Thunuguntla; Dhanusha Duraiyan; Alani Perkin; Katelyn Bagwill; Savannah Gonzales; Catheryn Sizemore; Vanessa Brizuela; Jaiyana King; Stephen Daly; Yoon Jae Chang; Mahdote Abebe; Yash Rajana; Kelly Wichmann; Christ Enyan; Shruthi Rangineni; Mark Fiala; Julie Fortier; Reyka Jayasinghe; Mark Schroeder; Li Ding; Ravi Vij; John DiPersio; Jessica Silva-Fisher
Advancing biological understanding of cellular senescence with computational multiomics

通过计算多组学推进对细胞衰老的生物学理解

Nature Genetics
IF0
2025-09-150
PRE
Sheng Li; Paula A. Agudelo Garcia; Constantin Aliferis; Michael J. Becich; Jazmin Calyeca; Benjamin D. Cosgrove; Jennifer Elisseeff; Negin Farzad; Elana J. Fertig; Carolyn Glass; Liangcai Gu; Qianjiang Hu; Zhicheng Ji; Melanie Königshoff; Nathan K. LeBrasseur; Dongmei Li; Anjun Ma; Qin Ma; Vilas Menon; Jacob T. Mitchell; Ana L. Mora; Sushma Nagaraj; Andrew C. Nelson; Laura J. Niedernhofer; Mauricio Rojas; Hash Brown Taha; Jinhua Wang; Siyuan Wang; Pei-Hsun Wu; Jichun Xie; Ming Xu; Miao Yu; Xu Zhang; Yue Zhao; Peter D. Adams; Cristina Aguayo-Mazzucato; Darren J. Baker; Christopher Benz; David A. Bernlohr; Marta Bueno; Jin Chen; Bennett G. Childs; Jeffrey H. Chuang; Dongjun Chung; Mythili Dileepan; Li Ding; Mingze Dong; Francesca Duncan; Archibald Enninful; William F. Flynn; Ana Catarina Franco; David Furman; Vesna Garovic; Stephanie Halene; Allison B. Herman; Ann V. Hertzel; Kanako Iwasaki; Hyeongseon Jeon; Jeon Woong Kang; Shilpita Karmakar; James L. Kirkland; Ron Korstanje; Erich Kummerfeld; Jun Hee Lee; Yang Liu; Yao Lu; Jose Lugo-Martinez; Helene Martini; Simon Melov; Nicolas Musi; João F. Passos; Samuel T. Peters; Irfan Rahman; Ramalakshmi Ramasamy; Alexandra N. Rindone; Paul D. Robbins; Paul Robson; Jhonny Rodriguez-Lopez; Lorena Rosas; Nadia Rosenthal; Marissa J. Schafer; Birgit Schilling; Elizabeth L. Schmidt; Kevin Schneider; Kaustav Sengupta; Jian Shu; Peter T. C. So; Li Sun; Tamar Tchkonia; Marcos G. Teneche; Natalia Vanegas; Julia Wang; Juan Xie; Shanshan Yin; Ke Zhang; Quan Zhu; Rong Fan
Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures

不同种族和暴露因素下肺腺癌的整合分析

Cancer Cell
IF44.5
2025-07-310
OAAI
Shankha Satpathy; Natalie M. Clark; Yi-Ju Chen; Noshad Hosseini; Ya-Hsuan Chang; Yi Hsiao; Jonathan T. Lei; Francesca Petralia; Jin-Shing Chen; Yifat Geffen; David I. Heiman; Indranil Paul; Hanbyul Cho; Michelle Hollenberg; Giacomo B. Marino; Kuen-Tyng Lin; Rahul Mannan; C. Jackson White; Joe Allen; Shayan C. Avanessian; M. Harry Kane; Ashley Wolfe; Miloni Kinarivala; Wenke Liu; Shankara Anand; Mong-Wei Lin; Moe Haines; Erik J. Bergstrom; Grant Hussey; Ginny Xiaohe Li; Deepak C. Mani; Hao Fang; Eric J. Jaehnig; Hasmik Keshishian; Brecca Miller; Kang-Yi Su; Yi-Jing Hsiao; Hsao-Hsun Hsu; Min-Shu Hsieh; Kuo-Hsuan Hsu; Alexi Monovoukas; Simone Gohsman; John R. Thorup; Yamei Deng; Yo Akiyama; Eden Deng; Eric Sheng-Wen Chen; Azra Krek; Rodrigo Espinoza; Weiping Ma; Daniel Charytonowicz; Robert Sebra; Jyun-Hong Lin; Yan-Si Chen; Yin-Chen Hsu; Ze-Shiang Lin; Kun-Chieh Chen; Chang-Wei Yeh; Yu-Tai Wang; Alexander J. Lazar; Mehdi Mesri; Eunkyung An; Xu Zhang; Karl R. Clauser; David Fenyö; Arul M. Chinnaiyan; Bing Zhang; Li Ding; Kelly Ruggles; Chelsea Newton; Hui Zhang; Pei Wang; Galen Hostetter; Gilbert S. Omenn; Chandan Kumar-Sinha; Mathangi Thiagarajan; Ramaswamy Govindan; Paul Paik; Abhijit Parolia; Qing K. Li; Avi Ma’ayan; Gad A. Getz; Saravana M. Dhanasekaran; Ana I. Robles; Gee-Chen Chang; Pan-Chyr Yang; Sung-Liang Yu; Hsuan-Yu Chen; Alexey I. Nesvizhskii; Steven A. Carr; D.R. Mani; Marcin P. Cieslik; Yu-Ju Chen; Michael A. Gillette
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy

种系遗传变异影响克隆造血景观和发展为恶性肿瘤

Nature Genetics
IF0
2025-07-150
OAAI
Jie Liu; Duc Tran; Liying Xue; Brian J. Wiley; Caitlyn Vlasschaert; Caroline J. Watson; Hamish A. J. MacGregor; Xiaoyu Zong; Irenaeus C. C. Chan; Indraniel Das; Md Mesbah Uddin; Abhishek Niroula; Gabriel Griffin; Benjamin L. Ebert; Taralynn Mack; Yash Pershad; Brian Sharber; Michael Berger; Ahmet Zehir; Ryan Ptashkin; Ross L. Levine; Elli Papaemmanuil; Vijai Joseph; Teng Gao; Yelena Kemel; Diana Mandelker; Konrad H. Stopsack; Paul D. P. Pharoah; Semanti Mukherjee; Li Ding; Yin Cao; Matthew J. Walter; Jamie R. Blundell; Nilanjan Chatterjee; Kenneth Offit; Lucy A. Godley; Daniel C. Link; Zsofia K. Stadler; Alexander G. Bick; Pradeep Natarajan; Kelly L. Bolton

研究方向

办公电话： 020-39943058联系邮箱： liding@mail.sysu.edu.cn
E
Elaine R. Mardis
H 指数:197论文数:1,691被引数:34.1万
R
Richard K. Wilson
H 指数:189论文数:682被引数:24.5万
M
Michael C. Wendl
H 指数:74论文数:269被引数:8.5万
M
Michael D. McLellan
H 指数:102论文数:235被引数:11.4万
R
Reyka G. Jayasinghe
H 指数:46论文数:233被引数:2.0万
M
Matthew A. Wyczalkowski
H 指数:43论文数:151被引数:1.6万
R
Robert S. Fulton
H 指数:154论文数:584被引数:21.6万
Ken Chen 封面图
Ken Chen
H 指数:102论文数:1,066被引数:9.9万
J
John F. DiPersio
H 指数:126论文数:1,370被引数:9.6万
R
Ryan C. Fields
H 指数:75论文数:878被引数:2.1万