未登录Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody
Al-Khami, Amir A.; Youssef, Sawsan; Abdiche, Yasmina; Nguyen, HoangKim; Chou, Joyce; Kimberlin, Christopher R.; Chin, Sherman M.; Kamperschroer, Cris; Jessen, Bart; Kern, Brent; Budimir, Natalija; Dillon, Christopher P.; Xu, Allison; Clark, Jerry D.; Chou, Jeffrey; Kraynov, Eugenia; Rajpal, Arvind; Lin, John C.; Salek-Ardakani, Shahram .png)
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收藏Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer (vol 9, 8420, 2019)Zhu, Guoyun; Foletti, Davide; Liu, Xiaohui; Ding, Sheng; Witt, Jody Melton; Hasa-Moreno, Adela; Rickert, Mathias; Holz, Charles; Aschenbrenner, Laura; Yang, Amy H.; Kraynov, Eugenia; Evering, Winston; Obert, Leslie; Lee, Chenyu; Sai, Tao; Mistry, Tina; Lindquist, Kevin C.; Van Blarcom, Thomas; Strop, Pavel; Chaparro-Riggers, Javier; Liu, Shu-Hui 分享 收藏 Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer通过CD3双特异性和ADC模式靶向CLDN18.2治疗胃癌和胰腺癌Zhu, Guoyun; Foletti, Davide; Liu, Xiaohui; Ding, Sheng; Witt, Jody Melton; Hasa-Moreno, Adela; Rickert, Mathias; Holz, Charles; Aschenbrenner, Laura; Yang, Amy H.; Kraynov, Eugenia; Evering, Winston; Obert, Leslie; Lee, Chenyu; Sai, Tao; Mistry, Tina; Lindquist, Kevin C.; Van Blarcom, Thomas; Strop, Pavel; Chaparro-Riggers, Javier; Liu, Shu-Hui 分享 收藏 Immunogenicity of immunomodulatory, antibody-based, oncology therapeuticsDavda, Jasmine; Declerck, Paul; Hu-Lieskovan, Siwen; Hickling, Timothy P.; Jacobs, Ira A.; Chou, Jeffrey; Salek-Ardakani, Shahram; Kraynov, Eugenia 分享 收藏 In vitro properties and pre-clinical activity of PF-06801591, a high-affinity engineered anti-human PD-1Youssef, Sawsan; Abdiche, Yasmina; Nguyen, HoangKim; Chou, Joyce; Chin, Sherman Michael; Kamperschroer, Cris; Schneider, Patricia A.; Kraynov, Eugenia; Krupka, Heike I.; Rajpal, Arvind; Lin, John 分享 收藏 RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor ModelsStrop, Pavel; Tran, Thomas-Toan; Dorywalska, Magdalena; Delaria, Kathy; Dushin, Russell; Wong, Oi Kwan; Ho, Wei-Hsien; Zhou, Dahui; Wu, Aidong; Kraynov, Eugenia; Aschenbrenner, Laura; Han, Bora; O'Donnell, Christopher J.; Pons, Jaume; Rajpal, Arvind; Shelton, Dave L.; Liu, Shu-Hui 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cellsQiu, Ming; Peng, Qinghai; Jiang, Ivy; Carroll, Christopher; Han, Guangzhou; Rymer, Isha; Lippincott, John; Zachwieja, Joseph; Gajiwala, Ketan; Kraynov, Eugenia; Thibault, Stephane; Stone, Donna; Gao, Yijie; Sofia, Susan; Gallo, Jorge; Li, Gang; Yang, Jennifer; Li, Kang; Wei, Ping 分享 收藏 分享 收藏 Discovery of Pyrroloaminopyrazoles as Novel PAK InhibitorsGuo, Chuangxing; McAlpine, Indrawan; Zhang, Junhu; Knighton, Daniel D.; Kephart, Susan; Johnson, M. Catherine; Li, Haitao; Bouzida, Djamal; Yang, Anle; Dong, Liming; Marakovits, Joseph; Tikhe, Jayashree; Richardson, Paul; Guo, Lisa C.; Kania, Robert; Edwards, Martin P.; Kraynov, Eugenia; Christensen, James; Piraino, Joseph; Lee, Joseph; Dagostino, Eleanor; Del-Carmen, Christine; Deng, Ya-Li; Smeal, Tod; Murray, Brion W. 分享 收藏 Inhibition of Notch signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cellsWei, Ping; Qiu, Ming; Jiang, Ivy; Carroll, Christopher; Han, Guangzhou; Rymer, Isha; Kraynov, Eugenia; Wu, Aidong; Thibault, Stephane; Stone, Donna; Gao, Yijie; Sofia, Susan; Gallo, Jorge; White, Janet; Li, Gary; Yang, Jennifer; Los, Gerrit 分享 收藏 Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancerShojaei, Farbod; Scott, Nathan; Kang, Xiaolin; Lappin, Patrick B.; Fitzgerald, Amanda A.; Karlicek, Shannon; Simmons, Brett H.; Wu, Aidong; Lee, Joseph H.; Bergqvist, Simon; Kraynov, Eugenia 分享 收藏 Inhibition of Notch signaling by a Notchl monoclonal antibody induces robust anti-tumor efficacy in T-cell acute lymphoblastic leukemia and breast cancerWei, Ping; Qiu, Ming; Peng, Qinghai; Lippincott, John; Zachwieja, Joseph; Kraynov, Eugenia; Wu, Aidong; Han, Bora; Stone, Donna; Zhai, Wenwu; Rymer, Isha; Yang, Jennifer; Gajiwala, Ketan; Yu, Xiu; Gao, Yijie; Tchistiakov, Lioudmila; Ma, Wenxue; Jamieson, Catriona H. M.; Los, Gerrit; Greenberg, Norman; Li, Kang 分享 收藏 PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic ActivityZhang, Cathy C.; Yan, Zhengming; Zhang, Qin; Kuszpit, Kyle; Zasadny, Kenneth; Qiu, Ming; Painter, Cory L.; Wong, Anthony; Kraynov, Eugenia; Arango, Maria E.; Mehta, Pramod P.; Popoff, Ian; Casperson, Gerald F.; Los, Gerrit; Bender, Steve; Anderes, Kenna; Christensen, James G.; VanArsdale, Todd 分享 收藏 Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growthMurray, Brion W.; Guo, Chuangxing; Piraino, Joseph; Westwick, John K.; Zhang, Cathy; Lamerdin, Jane; Dagostino, Eleanor; Knighton, Daniel; Loi, Cho-Ming; Zager, Michael; Kraynov, Eugenia; Popoff, Ian; Christensen, James G.; Martinez, Ricardo; Kephart, Susan E.; Marakovits, Joseph; Karlicek, Shannon; Bergqvist, Simon; Smeal, Tod 分享 收藏 Effect of PF-03475952, a potent and neutralizing CD44 antibody, on cancer cell apoptosis in vitro and metastasis in two orthotopic modelsWang, Yuli; Wang, Jean; Li, Gary; Jackson-Fisher, Amy; Brett, Simmons; Kraynov, Eugenia; Li, Baiyong; Pocalyko, David 分享 收藏 Discovery of p21-activated kinase inhibitor PF-03758309Guo, Chuangxing; Zhang, Junhu; McAlpine, Indrawan; Johnson, Catherine; Marakovits, Joseph; Dong, Liming; Kephart, Susan; Yang, Anle; Tikhe, Jayashree; Li, Haitao; Guo, Lisa; Bouzida, Djamal; Deng, Ya-Li; Knighton, Dan; Piraino, Joseph; Lee, Joseph; Smeal, Tod; Christensen, Jamie; Kraynov, Eugenia; Loi, Cho-Ming; Younis, Hasam; Dagostino, Eleanor; Murray, Brion W. 分享 收藏 Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1Blasina, Alessandra; Hallin, Jill; Chen, Enhong; Arango, Maria Elena; Kraynov, Eugenia; Register, James; Grant, Stephan; Ninkovic, Sacha; Chen, Ping; Nichols, Tim; O'Connor, Patrick; Anderes, Kenna 分享 收藏 
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