James D. Winkler - Publications, H-index & Citations

James D. Winkler

university of colorado anschutz medical campus

39H指数

164论文数

9.1K被引数

收录论文 44

发表时间

OKI-219, a PI3KaH1047R-mutant-selective inhibitor demonstrates efficacy as a single agent and drives combination responses with standard of care therapies in preclinical PI3KaH1047R mutant breast cancer models

CANCER RESEARCH

IF16.6

2024-05-02

PREAI

Taylor, Molly A.; Zhao, Qian; Mareska, David; Hoh, Maria; Izrayelit, Yevgeniy; Litwiler, Kevin; Boys, Mark L.; Woessner, Rich; Walker, Duncan; Winkler, James D.; Diamond, Jennifer

OKI-219 is an inhibitor of PI3K α H1047R that has brain penetrance and anti-tumor activity in a preclinical intracranial model of metastatic breast cancer

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Strait, Alexander A.; Taylor, Molly A.; Litwiler, Kevin S.; Zhao, Qian; Mareska, David A.; Boys, Mark L.; Izrayelit, Yevgeniy; Woessner, Richard; Winkler, James D.

Discovery and characterization of OKI-219, an orally bioavailable H1047R-mutant-selective inhibitor of PI3Kα

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Taylor, Molly A.; Zhao, Qian; Mareska, David; Hoh, Maria; Izrayelit, Yevgeniy; Litwiler, Kevin; Boys, Mark L.; Woessner, Rich; Walker, Duncan; Diamond, Jennifer; Winkler, James D.

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

MOLECULAR CANCER THERAPEUTICS

IF5.5

2022-03-04

OAAI

Diamond, Jennifer R.; Pitts, Todd M.; Ungermannova, Dana; Nasveschuk, Christopher G.; Zhang, Gan; Phillips, Andrew J.; Bagby, Stacey M.; Pafford, Jessica; Yacob, Betelehem W.; Newton, Timothy P.; Tentler, John J.; Gittleman, Brian; Hartman, Sarah J.; DeMattei, John A.; Winkler, James D.; Wendt, Michael K.; Schiemann, William P.; Eckhardt, S. Gail; Liu, Xuedong; Piscopio, Anthony D.

OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-12-01

PREAI

Diamond, Jennifer R.; Kagihara, Jodi A.; Liu, Xuedong; Gordon, Gilad; Heim, Amy M.; Winkler, James; DeMattei, John A.; Piscopio, Anthony D.; Eckhardt, S. Gail

Multiplex navigation of global regulatory networks (MINR) in yeast for improved ethanol tolerance and production

METABOLIC ENGINEERING

IF6.8

2019-01-01

OAAI

Liu, Rongming; Liang, Liya; Choudhury, Alaksh; Garst, Andrew D.; Eckert, Carrie A.; Oh, Eun Joong; Winkler, James; Gill, Ryan T.

Refactoring the Genetic Code for Increased Evolvability 重构遗传密码以提高可进化性

MBIO

IF4.7

2017-12-29

OAAI

Pines, Gur; Winkler, James D.; Pines, Assaf; Gill, Ryan T.

The Tolerome: A Database of Transcriptome-Level Contributions to Diverse Escherichia coli Resistance and Tolerance Phenotypes

ACS SYNTHETIC BIOLOGY

IF3.9

2017-10-19

PREAI

Erickson, Keesha E.; Winkler, James D.; Nguyen, Danh T.; Gill, Ryan T.; Chatterjee, Anushree

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-07-10

213

PREAI

Crew, Andrew P.; Raina, Kanak; Dong, Hanqing; Qian, Yimin; Wang, Jing; Vigil, Dominico; Serebrenik, Yevgeniy V.; Hamman, Brian D.; Morgan, Alicia; Ferraro, Caterina; Siu, Kam; Neklesa, Taavi K.; Winkler, James D.; Coleman, Kevin G.; Crews, Craig M.

Targeted protein degradation by PROTACs PROTACs的靶向蛋白质降解

PHARMACOLOGY & THERAPEUTICS

IF12.5

2017-06-01

457

PREAI

Neklesa, Taavi K.; Winkler, James D.; Crews, Craig M.

Benefits of a Recombination-Proficient Escherichia coli System for Adaptive Laboratory Evolution

APPLIED AND ENVIRONMENTAL MICROBIOLOGY

IF3.7

2016-11-15

OAAI

Peabody, George; Winkler, James; Fountain, Weston; Castro, David A.; Leiva-Aravena, Enzo; Kao, Katy C.

The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes

ACS SYNTHETIC BIOLOGY

IF3.9

2016-08-02

PREAI

Winkler, James D.; Halweg-Edwards, Andrea L.; Erickson, Keesha E.; Choudhury, Alaksh; Pines, Gur; Gill, Ryan T.

BRD4 degradation by PROTACs represents a more effective therapeutic strategy than BRD4 inhibitors in ovarian cancer

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Raina, Kanak; Lu, Jing; Qian, Yimin; Altieri, Martha; Dong, Hanging; Wang, Jing; Chen, Xin; Crew, Andrew; Coleman, Kevin; Crews, Craig; Winkler, James

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer PROTAC诱导的BET蛋白降解治疗去势抵抗性前列腺癌

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-06-06

713

OAAI

Raina, Kanak; Lu, Jing; Qian, Yimin; Altieri, Martha; Gordon, Deborah; Rossi, Ann Marie K.; Wang, Jing; Chen, Xin; Dong, Hanqing; Siu, Kam; Winkler, James D.; Crew, Andrew P.; Crews, Craig M.; Coleman, Kevin G.

A Web Interface for Codon Compression

ACS SYNTHETIC BIOLOGY

IF3.9

2016-05-19

PREAI

Halweg-Edwards, Andrea L.; Pines, Gur; Winkler, James D.; Pines, Assaf; Gill, Ryan T.

Complex systems in metabolic engineering

CURRENT OPINION IN BIOTECHNOLOGY

IF7

2015-12-01

OAAI

Winkler, James D.; Erickson, Keesha; Choudhury, Alaksh; Halweg-Edwards, Andrea L.; Gill, Ryan T.

Genome-Wide Tuning of Protein Expression Levels to Rapidly Engineer Microbial Traits 蛋白质表达水平的全基因组调整，以快速设计微生物性状

ACS SYNTHETIC BIOLOGY

IF3.9

2015-11-05

OAAI

Freed, Emily F.; Winkler, James D.; Weiss, Sophie J.; Garst, Andrew D.; Mutalik, Vivek K.; Arkin, Adam P.; Knight, Rob; Gill, Ryan T.

The emergence of commodity-scale genetic manipulation

CURRENT OPINION IN CHEMICAL BIOLOGY

IF6.1

2015-10-01

PREAI

Halweg-Edwards, Andrea L.; Grau, William C.; Winkler, James D.; Garst, Andrew D.; Gill, Ryan T.

Targeted degradation of the androgen receptor in prostate cancer

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Jin, Meizhong; Winkler, James D.; Coleman, Kevin; Crew, Andrew P.; Rossi, AnnMarie K.; Willard, Ryan R.; Dong, Hanqing; Siu, Kam; Wang, Jing; Gordon, Deborah A.; Chen, Xin; Ferraro, Caterina; Crews, Craig M.; Neklesa, Taavi K.

Bacterial Recombineering: Genome Engineering via Phage-Based Homologous Recombination

ACS SYNTHETIC BIOLOGY

IF3.9

2015-04-27

PREAI

Pines, Gur; Freed, Emily F.; Winkler, James D.; Gill, Ryan T.

研究方向