未登录 分享 收藏
Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study Bissonnette, Robert; Dubois, Janet; Facheris, Paola; Del Duca, Ester; Kim, Madeline; Da Rosa, Joel Correa; Trujillo, Damian L.; Bose, Swaroop; Pagan, Angel D.; Wustrow, David; Brockstedt, Dirk G.; Wong, Brian; Kassner, Paul D.; Jankicevic, Jasmina; Ho, William; Cheng, Laurence E.; Guttman-Yassky, Emma 分享 收藏
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4 Marshall, Lisa A.; Marubayashi, Sachie; Jorapur, Aparna; Jacobson, Scott; Zibinsky, Mikhail; Robles, Omar; Hu, Dennis Xiaozhou; Jackson, Jeffrey J.; Pookot, Deepa; Sanchez, Jerick; Brovarney, Martin; Wadsworth, Angela; Chian, David; Wustrow, David; Kassner, Paul D.; Cutler, Gene; Wong, Brian; Brockstedt, Dirk G.; Talay, Oezcan 分享 收藏
Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7 与TRAF7种系变异相关的表型谱和转录组谱 Castilla-Vallmanya, Laura; Selmer, Kaja K.; Dimartino, Clemantine; Rabionet, Raquel; Blanco-Sanchez, Bernardo; Yang, Sandra; Reijnders, Margot R. F.; van Essen, Antonie J.; Oufadem, Myriam; Vigeland, Magnus D.; Stadheim, Barbro; Houge, Gunnar; Cox, Helen; Kingston, Helen; Clayton-Smith, Jill; Innis, Jeffrey W.; Iascone, Maria; Cereda, Anna; Gabbiadini, Sara; Chung, Wendy K.; Sanders, Victoria; Charrow, Joel; Bryant, Emily; Millichap, John; Vitobello, Antonio; Thauvin, Christel; Mau-Them, Frederic Tran; Faivre, Laurence; Lesca, Gaetan; Labalme, Audrey; Rougeot, Christelle; Chatron, Nicolas; Sanlaville, Damien; Christensen, Katherine M.; Kirby, Amelia; Lewandowski, Raymond; Gannaway, Rachel; Aly, Maha; Lehman, Anna; Clarke, Lorne; Graul-Neumann, Luitgard; Zweier, Christiane; Lessel, Davor; Lozic, Bernarda; Aukrust, Ingvild; Peretz, Ryan; Stratton, Robert; Smol, Thomas; Dieux-Coeslier, Anne; Meira, Joanna; Wohler, Elizabeth; Sobreira, Nara; Beaver, Erin M.; Heeley, Jennifer; Briere, Lauren C.; High, Frances A.; Sweetser, David A.; Walker, Melissa A.; Keegan, Catherine E.; Jayakar, Parul; Shinawi, Marwan; Kerstjens-Frederikse, Wilhelmina S.; Earl, Dawn L.; Siu, Victoria M.; Reesor, Emma; Yao, Tony; Hegele, Robert A.; Vaske, Olena M.; Rego, Shannon; Shapiro, Kevin A.; Wong, Brian; Gambello, Michael J.; McDonald, Marie; Karlowicz, Danielle; Colombo, Roberto; Serretti, Alessandro; Pais, Lynn; O'Donnell-Luria, Anne; Wray, Alison; Sadedin, Simon; Chong, Belinda; Tan, Tiong Y.; Christodoulou, John; White, Susan M.; Slavotinek, Anne; Barbouth, Deborah; Swols, Dayna Morel; Parisot, Melanie; Bole-Feysot, Christine; Nitschke, Patrick; Pingault, Veronique; Munnich, Arnold; Cho, Megan T.; Cormier-Daire, Valerie; Balcells, Susanna; Lyonnet, Stanislas; Grinberg, Daniel; Amiel, Jeanne; Urreizti, Roser; Gordon, Christopher T. 分享 收藏
分享 收藏
分享 收藏
Synthesis of Akt Inhibitor Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up Remarchuk, Travis; St-Jean, Frederic; Carrera, Diane; Savage, Scott; Yajima, Herbert; Wong, Brian; Babu, Srinivasan; Deese, Alan; Stults, Jeffrey; Dong, Michael W.; Askin, David; Lane, Jonathan W.; Spencer, Keith L. 分享 收藏
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome Zhang, Hongbing; Pao, Lily I.; Zhou, Aileen; Brace, Arthur D.; Halenbeck, Robert; Hsu, Amy W.; Bray, Thomas L.; Hestir, Kevin; Bosch, Elizabeth; Lee, Ernestine; Wang, Gang; Liu, Haixia; Wong, Brian R.; Kavanaugh, W. Michael; Williams, Lewis T. 分享 收藏
分享 收藏
分享 收藏
Discovery of 6-(2,4-Difluorophenoxy)-2[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, JoAnn; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; Pablo, Bong San; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim 分享 收藏
The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells interleukin-1受体相关激酶 (IRAK)-1和4的激酶活性在人细胞中炎性细胞因子表达的控制中是多余的 Song, Kyung W.; Talamas, Francisco X.; Suttmann, Rebecca T.; Olson, Pam S.; Barnett, Jim W.; Lee, Simon W.; Thompson, Kelly D.; Jin, Sue; Hekmat-Nejad, Mohammad; Cai, Terrence Z.; Manning, Anthony M.; Hill, Ronald J.; Wong, Brian R. 分享 收藏
Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity Hill, Ronald J.; Dabbagh, Karim; Phippard, Deborah; Li, Ching; Suttmann, Rebecca T.; Welch, Mary; Papp, Eva; Song, Kyung W.; Chang, Kung-Ching; Leaffer, David; Kim, Yong-Nam; Roberts, Richard T.; Zabka, Tanja S.; Aud, Dee; Dal Porto, Joseph; Manning, Anthony M.; Peng, Stanford L.; Goldstein, David M.; Wong, Brian R. 分享 收藏
分享 收藏
R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammation R406，一种口服脾酪氨酸激酶抑制剂阻断Fc受体信号传导并减少免疫复合物介导的炎症 Braselmann, Sylvia; Taylor, Vanessa; Zhao, Haoran; Wang, Su; Sylvain, Catherine; Baluom, Muhammad; Qu, Kunbin; Herlaar, Ellen; Lau, Angela; Young, Chi; Wong, Brian R.; Lovell, Scott; Sun, Thomas; Park, Gary; Argade, Ankush; Jurcevic, Stipo; Pine, Polly; Singh, Rajinder; Grossbard, Elliott B.; Payan, Donald G.; Masuda, Esteban S. 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
