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收藏分享 收藏 分享 收藏 Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl) carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor
Watanabe, Kazushi; Kakefuda, Akio; Yasuda, Minoru; Enjo, Kentaro; Kikuchi, Aya; Furutani, Takashi; Naritomi, Yoichi; Otsuka, Yukio; Okada, Minoru; Ohta, Mitsuaki 分享 收藏 Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543含2型糖尿病的选择性SGLT2抑制剂的合成和生物学评价: YM543的发现Ikegai, Kazuhiro; Imamura, Masakazu; Suzuki, Takayuki; Nakanishi, Keita; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki 分享 收藏 分享 收藏 分享 收藏 Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6, 7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase InhibitorAsano, Toni; Yamazaki, Hitoshi; Kasahara, Chiyoshi; Kubota, Hirokazu; Kontani, Toni; Harayama, Yu; Ohno, Kazuki; Mizuhara, Hidekazu; Yokomoto, Masaharu; Misumi, Keiji; Kinoshita, Tomohiko; Ohta, Mitsuaki; Takeuchi, Makoto 分享 收藏 Discovery of ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitusImamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki 分享 收藏 分享 收藏 Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitorsNagashima, Shinya; Hondo, Takeshi; Nagata, Hiroshi; Ogiyama, Takashi; Maeda, Jun; Hoshii, Hiroaki; Kontani, Toru; Kuromitsu, Sadao; Ohga, Keiko; Orita, Masaya; Ohno, Kazuki; Moritomo, Ayako; Shiozuka, Koichi; Furutani, Masako; Takeuchi, Makoto; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi 分享 收藏 分享 收藏 Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonistsSato, Ippei; Morihira, Koichiro; Inami, Hiroshi; Kubota, Hirokazu; Morokata, Tatsuaki; Suzuki, Keiko; Ohno, Kazuki; Iura, Yosuke; Nitta, Aiko; Imaoka, Takayuki; Takahashi, Toshiya; Takeuchi, Makoto; Ohta, Mitsuaki; Tsukamoto, Shin-ichi 分享 收藏 分享 收藏 Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective β3-adrenergic receptor agonistsMaruyama, Tatsuya; Onda, Kenichi; Hayakawa, Masahiko; Seki, Norio; Takahashi, Takumi; Moritomo, Hiroyuki; Suzuki, Takayuki; Matsui, Tetsuo; Takasu, Toshiyuki; Nagase, Itsuro; Ohta, Mitsuaki 分享 收藏 Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolinesYokoyama, Kazuhiro; Ishikawa, Noriko; Igarashi, Susumu; Kawano, Noriyuki; Masuda, Naoyuki; Hamaguchi, Wataru; Yamasaki, Shingo; Koganemaru, Yohei; Hattori, Kazuyuki; Miyazaki, Takahiro; Ogino, Shin-ichi; Matsumoto, Yuzo; Takeuchi, Makoto; Ohta, Mitsuaki 分享 收藏 Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitorsOnda, Kenichi; Shiraki, Ryota; Ogiyama, Takashi; Yokoyama, Kazuhiro; Momose, Kazuhiro; Katayama, Naoko; Orita, Masaya; Yamaguchi, Tomohiko; Furutani, Masako; Hamada, Noritaka; Takeuchi, Makoto; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi 分享 收藏 Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilidesYonetoku, Yasuhiro; Kubota, Hirokazu; Miyazaki, Yoji; Okamoto, Yoshinori; Funatsu, Masashi; Yoshimura-Ishikawa, Noriko; Ishikawa, Jun; Yoshino, Taiji; Takeuchi, Makoto; Ohta, Mitsuaki 分享 收藏 Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolinesYokoyama, Kazuhiro; Ishikawa, Noriko; Igarashi, Susumu; Kawano, Noriyuki; Masuda, Naoyuki; Hattori, Kazuyuki; Miyazaki, Takahiro; Ogino, Shin-ichi; Orita, Masaya; Matsumoto, Yuzo; Takeuchi, Makoto; Ohta, Mitsuaki 分享 收藏 Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibitionSato, Ippei; Morihira, Koichiro; Inami, Hiroshi; Kubota, Hirokazu; Morokata, Tatsuaki; Suzuki, Keiko; Iura, Yosuke; Nitta, Aiko; Imaoka, Takayuki; Takahashi, Toshiya; Takeuchi, Makoto; Ohta, Mitsuaki; Tsukamoto, Shin-ichi 分享 收藏 
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