未登录 分享 收藏
Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator Golder, Francis J.; Dax, Scott; Baby, Santhosh M.; Gruber, Ryan; Hoshi, Toshinori; Ideo, Courtney; Kennedy, Andrew; Peng, Sean; Puskovic, Veljko; Ritchie, David; Woodward, Richard; Wardle, Robert L.; Van Scott, Michael R.; Mannion, James C.; MacIntyre, D. Euan 分享 收藏
Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker Abbadie, Catherine; McManus, Owen B.; Sun, Shu-Yu; Bugianesi, Randal M.; Dai, Ge; Haedo, Rodolfo J.; Herrington, James B.; Kaczorowski, Gregory J.; Smith, McHardy M.; Swensen, Andrew M.; Warren, Vivien A.; Williams, Brande; Arneric, Stephen P.; Eduljee, Cyrus; Snutch, Terrance P.; Tringham, Elizabeth W.; Jochnowitz, Nina; Liang, Annie; MacIntyre, D. Euan; McGowan, Erin; Mistry, Shruti; White, Valerie V.; Hoyt, Scott B.; London, Clare; Lyons, Kathryn A.; Bunting, Patricia B.; Volksdorf, Sylvia; Duffy, Joseph L. 分享 收藏
分享 收藏
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents Shearman, Lauren P.; Stribling, D. Sloan; Camacho, Ramon E.; Rosko, Kimberly M.; Wang, Junying; Tong, Sharon; Feng, Yue; Marsh, Donald J.; Yu, Hong; Guan, Xiaoming; Spann, Stephanie K.; MacNeil, Douglas J.; Fong, Tung M.; Metzger, Joseph M.; Goulet, Mark T.; Hagmann, William K.; Plummer, Christopher W.; Finke, Paul E.; Mills, Sander G.; Shah, Shrenik K.; Truong, Quang; Van der Ploeg, L. H. T.; Maclntyre, D. Euan; Strack, Alison M. 分享 收藏
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in rodents Fong, Tung M.; Guan, Xiao-Ming; Marsh, Donald J.; Shen, Chun-Pyn; Sloan Stribling, D.; Rosko, Kim M.; Lao, Julie; Yu, Hong; Feng, Yue; Xiao, Jing C.; Van der Ploeg, Lex H. T.; Goulet, Mark T.; Hagmann, Williams K.; Lin, Linus S.; Lanza, Thomas J., Jr.; Jewell, James P.; Liu, Ping; Shah, Shrenik K.; Qi, Hongbo; Tong, Xinchun; Wang, Junying; Xu, Suoyu S.; Francis, Barbara; Strack, Alison M.; MacIntyre, D. Euan; Shearman, Lauren P. 分享 收藏
Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice Shearman, LP; Wang, SP; Helmling, S; Stribling, DS; Mazur, P; Ge, L; Wang, LY; Klussmann, S; Macintyre, DE; Howard, AD; Strack, AM 分享 收藏
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav1.9 to sensory transmission and nociceptive behavior Priest, BT; Murphy, BA; Lindia, JA; Diaz, C; Abbadie, C; Ritter, AM; Liberator, P; Iyer, LM; Kash, SF; Kohler, MG; Kaczorowski, GJ; MacIntyre, DE; Martin, WJ 分享 收藏
The target of ezetimibe is Niemann-Pick Cl-Like 1 (NPC1L1) Garcia-Calvo, M; Lisnock, JM; Bull, HG; Hawes, BE; Burnett, DA; Braun, MP; Crona, JH; Davis, HR; Dean, DC; Detmers, PA; Graziano, MP; Hughes, M; MacIntyre, DE; Ogawa, A; O'Neill, KA; Iyer, SPN; Shevell, DE; Smith, MM; Tang, YS; Makarewicz, AM; Ujjainwalla, F; Altmann, SW; Chapman, KT; Thornberry, NA 分享 收藏
Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats 慢性MCH-1受体调节会改变大鼠的食欲，体重和肥胖 Shearman, LP; Camacho, RE; Stribling, DS; Zhou, D; Bednarek, MA; Hreniuk, DL; Feighner, SD; Tan, CP; Howard, AD; Van der Ploeg, LHT; MacIntyre, DE; Hickey, GJ; Strack, AM 分享 收藏
Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula Martin, WJ; McGowan, E; Cashen, DE; Gantert, LT; Drisko, JE; Hom, GJ; Nargund, R; Sebhat, I; Howard, AD; Van der Ploeg, LHT; MacIntyre, DE 分享 收藏
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist Sebhat, IK; Martin, WJ; Ye, ZX; Barakat, K; Mosley, RT; Johnston, DBR; Bakshi, R; Palucki, B; Weinberg, DH; MacNeil, T; Kalyani, RN; Tang, R; Stearns, RA; Miller, RR; Tamvakopoulos, C; Strack, AM; McGowan, E; Cashen, DE; Drisko, JE; Hom, GJ; Howard, AD; MacIntyre, DE; van der Ploeg, LHT; Patchett, AA; Nargund, RP 分享 收藏
A role for the melanocortin 4 receptor in sexual function Van der Ploeg, LHT; Martin, WJ; Howard, AD; Nargund, RP; Austin, CP; Guan, XM; Drisko, J; Cashen, D; Sebhat, I; Patchett, AA; Figueroa, DJ; DiLella, AG; Connolly, BM; Weinberg, DH; Tan, CP; Palyha, OC; Pong, SS; MacNeil, T; Rosenblum, C; Vongs, A; Tang, R; Yu, H; Sailer, AW; Fong, TM; Huang, C; Tota, MR; Chang, RS; Stearns, R; Tamvakopoulos, C; Christ, G; Drazen, DL; Spar, BD; Nelson, RJ; MacIntyre, DE 分享 收藏
IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANE HUMAN NK1 ANTAGONISTS SWAIN, CJ; SEWARD, EM; CASCIERI, MA; FONG, TM; HERBERT, R; MACINTYRE, DE; MERCHANT, KJ; OWEN, SN; OWENS, AP; SABIN, V; TEALL, M; VANNIEL, MB; WILLIAMS, BJ; SADOWSKI, S; STRADER, C; BALL, RG; BAKER, R 分享 收藏
SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN MACLEOD, AM; CASCIERI, MA; MERCHANT, KJ; SADOWSKI, S; HARDWICKE, S; LEWIS, RT; MACINTYRE, DE; METZGER, JM; FONG, TM; SHEPHEARD, S; TATTERSALL, FD; HARGREAVES, R; BAKER, R 分享 收藏
Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism Marsh, DJ; Weingarth, DT; Novi, DE; Chen, HY; Trumbauer, ME; Chen, AS; Guan, XM; Jiang, MM; Feng, Y; Camacho, RE; Shen, Z; Frazier, EG; Yu, H; Metzger, JM; Kuca, SJ; Shearman, LP; Gopal-Truter, S; MacNeil, DJ; Strack, AM; MacIntyre, DE; Van der Ploeg, LHT; Qian, S 分享 收藏
A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor DeVita, RJ; Walsh, TF; Young, JR; Jiang, JL; Ujjainwalla, F; Toupence, RB; Parikh, M; Huang, SX; Fair, JA; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Cui, JS; Mount, G; Rohrer, SP; Schaeffer, JM; Rhodes, L; Drisko, JE; McGowan, E; MacIntyre, DE; Vincent, S; Carlin, JR; Cameron, J; Smith, RG 分享 收藏
Discovery of a potent, orally bioavailable β3 adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE 分享 收藏
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs Hale, JJ; Mills, SG; MacCoss, M; Dorn, CP; Finke, PE; Budhu, RJ; Reamer, RA; Huskey, SEW; Luffer-Atlas, D; Dean, BJ; McGowan, EM; Feeney, WP; Chiu, SHL; Cascieri, MA; Chicchi, GG; Kurtz, MM; Sadowski, S; Ber, E; Tattersall, FD; Rupniak, NMJ; Williams, AR; Rycroft, W; Hargreaves, R; Metzger, JM; MacIntyre, DE 分享 收藏
4,4-disubstituted piperidine high-affinity NK1 antagonists:: Structure-activity relationships and in vivo activity Stevenson, GI; Huscroft, I; MacLeod, AM; Swain, CJ; Cascieri, MA; Chicchi, GG; Graham, MI; Harrison, T; Kelleher, FJ; Kurtz, M; Ladduwahetty, T; Merchant, KJ; Metzger, JM; MacIntyre, DE; Sadowski, S; Sohal, B; Owens, AP 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}