未登录S227928: A Novel Anti-CD74 ADC with MCL-1 Inhibitor Payload for the Treatment of Acute Myeloid Leukemia (AML) and Other Hematologic MalignanciesS227928：一种新型的抗CD74抗体药物偶联物（ADC），其载药为MCL-1抑制剂，用于治疗急性髓系白血病（AML）及其他血液系统恶性肿瘤
Maragno, Ana-Leticia; Seiss, Katherine; Newcombe, Rick; Mistry, Prakash; Schnell, Christian R.; Von Arx, Fabian; Koenig, Julie; Malamas, Anthony S.; Le Toumelin-Braizat, Gaetane; Bresson, Laura; Rocchetti, Francesca; Demarles, Didier; Kurth, Esther; Renteria, Lorena; Hainzl, Dominik; Engelhardt, Volker; Liot, Caroline; Madelain, Vincent; Kostova, Vesela; Starck, Jerome-Benoit; Valour, Damien; Franzetti, Georges-Alain; Colland, Frederic; Vostiarova, Helena; Tschantz, William R.; Bachmann, Nicholas; Palacio-Ramirez, Sebastian; Burger, Matthew; Campbell, Jennifer M.; Chen, Zhuoliang; Koenig, Robert; Mcneill, Eric; Mo, Ruowei; Nakajima, Katsumasa; Palermo, Mark; Shen, Yiping; Yu, Bing; Zambrowski, Mark; Zhang, Alan; Zecri, Frederic; Broniscer, Alberto; Geneste, Olivier; Horton, Kristin; D'Alessio, Joseph A. .png)
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收藏Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced MalignanciesHuang, Ying; Sendzik, Martin; Zhang, Jeff; Gao, Zhenting; Sun, Yongfeng; Wang, Long; Gu, Justin; Zhao, Kehao; Yu, Zhengtian; Zhang, Lijun; Zhang, Qiong; Blanz, Joachim; Chen, Zijun; Dubost, Valerie; Fang, Douglas; Feng, Lijian; Fu, Xingnian; Kiffe, Michael; Li, Ling; Luo, Fangjun; Luo, Xiao; Mi, Yuan; Mistry, Prakash; Pearson, David; Piaia, Alessandro; Scheufler, Clemens; Terranova, Remi; Weiss, Andreas; Zeng, Jue; Zhang, Hailong; Zhang, Jiangwei; Zhao, Mengxi; Dillon, Michael P.; Jeay, Sebastien; Qi, Wei; Moggs, Jonathan; Pissot-Soldermann, Carole; Li, En; Atadja, Peter; Lingel, Andreas; Oyang, Counde 分享 收藏 Targeting AML through apoptosis activation using Bcl-2/Mcl-1 or Bcl-2/Hdm2 inhibitor combination therapiesWang, Youzhen; Qui, Shumei; Sanghavi, Sneha; Mulford, Lain; Lysiak, Gaelle; Chanrion, Maia; Mistry, Prakash; Pfaar, Ulrike; Schoumacher, Marie; Claperon, Audrey; Kraus-Berthier, Laurence; Banquet, Sebastien; Derreal, Alix; Fabre, Claire; Maacke, Heiko; Colland, Frederic; Geneste, Olivier; Morris, Erick; Halilovic, Ensar 分享 收藏 S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor modelsMaragno, Ana Leticia; Mistry, Prakash; Kotschy, Andras; Szlavik, Zoltan; Murray, James; Davidson, James; Le Toumelin-Braizat, Gaetane; Chanrion, Maia; Bruno, Alain; Claperon, Audrey; Maacke, Heiko; Morris, Erick; Wang, Youzhen; Derreal, Alix; Csekei, Marton; Paczal, Attila; Szabo, Zoltan; Sipos, Szabolcs; Proszenyak, Agnes; Balint, Balazs; Surgenor, Allan; Dokurno, Pawel; Matassova, Natalia; Chen, Ijen; Lysiak-Auvity, Gaelle; Girard, Anne-Marie; Grave, Fabienne; Colland, Frederic; Halilovic, Ensar; Geneste, Olivier 分享 收藏 MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignanciesHalilovic, Ensar; Chanrion, Maia; Mistry, Prakash; Wartmann, Markus; Qiu, Shumei; Sanghavi, Sneha; Chen, Yan; Lysiak, Gaelle; Maragno, Ana Leticia; Pfaar, Ulrike; Huth, Felix; Schoumacher, Marie; Claperon, Audrey; Kraus-Berthier, Laurence; Banquet, Sebastien; Derreal, Alix; Maacke, Heiko; Colland, Frederic; Geneste, Olivier; Morris, Erick; Wang, Youzhen 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1-5 of a 3-weekly cycle in patients with advanced solid tumoursde Jonge, MJA; Kaye, S; Verweij, J; Brock, C; Reade, S; Scurr, M; van Doorn, L; Verheij, C; Loos, W; Brindley, C; Mistry, P; Cooper, M; Judson, I 分享 收藏 分享 收藏 Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance吡咯并嘧啶作为多药耐药相关蛋白选择性抑制剂的研究Wang, SM; Folkes, A; Chuckowree, I; Cockcroft, X; Sohal, S; Miller, W; Milton, J; Wren, SP; Vicker, N; Depledge, P; Scott, J; Smith, L; Jones, H; Mistry, P; Faint, R; Thompson, D; Cocks, S 分享 收藏 Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistanceWang, SM; Wan, NC; Harrison, J; Miller, W; Chuckowree, I; Sohal, S; Hancox, TC; Baker, S; Folkes, A; Wilson, F; Thompson, D; Cocks, S; Farmer, H; Boyce, A; Freathy, C; Broadbridge, J; Scott, J; Depledge, P; Faint, R; Mistry, P; Charlton, P 分享 收藏 Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agentsVicker, N; Burgess, L; Chuckowree, IS; Dodd, R; Folkes, AJ; Hardick, DJ; Hancox, TC; Miller, W; Milton, J; Sohal, S; Wang, SM; Wren, SP; Charlton, PA; Dangerfield, W; Liddle, C; Mistry, P; Stewart, AJ; Denny, WA 分享 收藏 Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agentsGamage, SA; Spicer, JA; Rewcastle, GW; Milton, J; Sohal, S; Dangerfield, W; Mistry, P; Vicker, N; Charlton, PA; Denny, WA 分享 收藏 分享 收藏 In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistanceMistry, P; Plumb, J; Eccles, S; Watson, S; Dale, I; Ryder, H; Box, G; Charlton, P; Templeton, D; Bevan, PB 分享 收藏 Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivativeDale, IL; Tuffley, W; Callaghan, R; Holmes, JA; Martin, K; Luscombe, M; Mistry, P; Ryder, H; Stewart, AJ; Charlton, P; Twentyman, PR; Bevan, P 分享 收藏 
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