未登录 Preliminary Safety and Pharmacokinetics of the MET-TKI DO-2 in Patients with Advanced Solid Tumors Harboring MET Aberrations: A Phase I Study Perera, T.; Sikkema, B.; Dekeyser, B.; de Bruijn, P.; Zammit, F.; Galot, R.; Machielsjean-pascal, J. P.; Delafontaine, B.; Rottey, S.; Swalduz, A.; Ghiringhelli, F.; Piet, B.; van Herpen, C.; Cortot, A.; Wastelin, F.; Verweij, J.; Mathijssen, R.; Robbrecht, D.; Prenen, H. 分享 收藏
Empowering effective biomarker-driven precision oncology: A call to action * Lawler, Mark; Keeling, Peter; Kholmanskikh, Olga; Minnaard, Warnyta; Moehlig-Zuttermeister, Heike; Normanno, Nicola; Philip, Reena; Popp, Claudia; Salgado, Roberto; Santiago-Walker, Ademi E.; Trullas, Ana; van Waalwijk van Doorn-Khosrovani, Sahar B.; Vart, Richard; Vermeulen, Jessica; Vitaloni, Marianna; Verweij, Jaap 分享 收藏
Preclinical and emerging Phase 1 study data indicates that novel deuterated MET kinase inhibitor DO-2 mitigates the side effects seen with current approved MET kinase inhibitors: Preventing deleterious ′de-hinging′ to improve tolerability Perera, Timothy P. S.; Mevellec, Laurence; Prenen, Hans; Dekeyser, Bernd; Robbrecht, Debbie; Bins, Sander; Sikkema, Barend; de Bruijn, Peter; Machiels, Jean-Pascal; Galot, Rachel; Briol, Damien; Knight, Richard; Loryan, Irena; Hu, Yang; Wastelin, Florence; Verweij, Jaap 分享 收藏
A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation (vol 27, pg 6366, 2021) Atrafi, Florence; Boix, Oliver; Subbiah, Vivek; Diamond, Jennifer R.; Chawla, Sant P.; Tolcher, Anthony W.; LoRusso, Patricia M.; Eder, Joseph P.; Gutierrez, Martin; Sankhala, Kumar; Rajagopalan, Prabhu; Genvresse, Isabelle; Langer, Simon; Mathijssen, Ron H. J.; Verweij, Jaap; Bruns, Ingmar; Lolkema, Martijn P. 分享 收藏
Ektacytometry Analysis of Post-splenectomy Red Blood Cell Properties Identifies Cell Membrane Stability Test as a Novel Biomarker of Membrane Health in Hereditary Spherocytosis Berrevoets, M. C.; Bos, J.; Huisjes, R.; Merkx, T. H.; van Oirschot, B. A.; van Solinge, W. W.; Verweij, J. W.; Lindeboom, M. Y. A.; van Beers, E. J.; Bartels, M.; van Wijk, R.; Rab, M. A. E. 分享 收藏
Iniparib administered weekly or twice-weekly in combination with gemcitabine/carboplatin in patients with metastatic triple-negative breast cancer: a phase II randomized open-label study with pharmacokinetics 在转移性三阴性乳腺癌患者中，每周或每周两次使用Iniparib联合吉西他滨/卡铂: 一项具有药代动力学的II期随机开放标签研究 Dieras, Veronique; Bonnefoi, Herve; Alba, Emilio; Awada, Ahmad; Coudert, Bruno; Pivot, Xavier; Gligorov, Joseph; Jager, Agnes; Zambelli, Stefania; Lindeman, Geoffrey J.; Charpentier, Eric; Emmons, Gary T.; Garcia-Ribas, Ignacio; Paridaens, Robert; Verweij, Jaap 分享 收藏
Innovation in oncology clinical trial design Verweij, J.; Hendriks, H. R.; Zwierzina, H.; Hanauske; Wacheck, V.; Collignon, O.; Bruzzi, P.; Gross, J.; Riehl, T.; Bretz, F.; Dollins; Radtke, I. 分享 收藏
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miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway miR-634通过靶向ras-mapk通路恢复耐药卵巢癌细胞的药物敏感性 van Jaarsveld, Marijn T. M.; van Kuijk, Patricia F.; Boersma, Antonius W. M.; Helleman, Jozien; van IJcken, Wilfred F.; Mathijssen, Ron H. J.; Pothof, Joris; Berns, Els M. J. J.; Verweij, Jaap; Wiemer, Erik A. C. 分享 收藏
Hypertension (HTN) as a potential biomarker of efficacy in pazopanib-treated patients with advanced non-adipocytic soft tissue sarcoma. A retrospective study based on European Organisation for Research and Treatment of Cancer (EORTC) 62043 and 62072 trials Duffaud, F.; Sleijfer, S.; Litiere, S.; Ray-Coquard, I.; Le Cesne, A.; Papai, Z.; Judson, I.; Schoeffski, P.; Chawla, S. P.; Dewji, R.; Marreaud, S.; Verweij, J.; van der Graaf, W. T. 分享 收藏
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Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib Lee, Chee Khoon; Goldstein, David; Gibbs, Emma; Joensuu, Heikki; Zalcberg, John; Verweij, Jaap; Casali, Paolo G.; Maki, Robert G.; Cioffi, Angela; Mcarthur, Grant; Lord, Sarah J.; Yip, Desmond; Kanjanapan, Yada; Rutkowski, Piotr 分享 收藏
Recurrence of Melanoma Following T Cell Treatment: Continued Antigen Expression in a Tumor That Evades T Cell Recruitment Straetemans, Trudy; Berrevoets, Cor; Coccoris, Miriam; Treffers-Westerlaken, Elike; Wijers, Rebecca; Cole, David K.; Dardalhon, Valerie; Sewell, Andrew K.; Taylor, Naomi; Verweij, Jaap; Debets, Reno 分享 收藏
Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials Le Cesne, A.; Ouali, M.; Leahy, M. G.; Santoro, A.; Hoekstra, H. J.; Hohenberger, P.; Van Coevorden, F.; Rutkowski, P.; Van Hoesel, R.; Verweij, J.; Bonvalot, S.; Steward, W. P.; Gronchi, A.; Hogendoorn, P. C. W.; Litiere, S.; Marreaud, S.; Blay, J. Y.; Van der Graaf, W. T. A. 分享 收藏
Dose-Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study Garcia, Victor Moreno; Olmos, David; Gomez-Roca, Carlos; Cassier, Philippe A.; Morales-Barrera, Rafael; Del Conte, Gianluca; Gallerani, Elisa; Brunetto, Andre T.; Schoeffski, Patrick; Marsoni, Silvia; Schellens, Jan H. M.; Penel, Nicolas; Voest, Emile; Evans, Jeffrey; Plummer, Ruth; Wilson, Richard H.; Soria, Jean Charles; Tabernero, Josep; Verweij, Jaap; Kaye, Stan B. 分享 收藏
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Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps Burger, H; van Tol, H; Brok, M; Wiemer, EAC; de Bruijn, EA; Guetens, G; de Boeck, G; Sparreboom, A; Verweij, J; Nooter, K 分享 收藏
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