未登录 MUFINS: multi-formalism interaction network simulator Wu, Huihai; von Kamp, Axel; Leoncikas, Vytautas; Mori, Wataru; Sahin, Nilgun; Gevorgyan, Albert; Linley, Catherine; Grabowski, Marek; Mannan, Ahmad A.; Stoy, Nicholas; Stewart, Graham R.; Ward, Lara T.; Lewis, David J. M.; Sroka, Jacek; Matsuno, Hiroshi; Klamt, Steffen; Westerhoff, Hans V.; McFadden, Johnjoe; Plant, Nicholas J.; Kierzek, Andrzej M. 分享 收藏
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxylethy]-1,3-dimethyl-piperazin-2-one (AZD5153) Bradbury, Robert H.; Callis, Rowena; Carr, Gregory R.; Chen, Huawei; Clark, Edwin; Feron, Lyman; Glossop, Steve; Graham, Mark A.; Hattersley, Maureen; Jones, Chris; Lamont, Scott G.; Ouvry, Gilles; Patel, Anil; Patel, Joe; Rabow, Alfred A.; Roberts, Craig A.; Stokes, Stephen; Stratton, Natalie; Walker, Graeme E.; Ward, Lara; Whalley, David; Whittaker, David; Wrigley, Gail; Waring, Michael J. 分享 收藏
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers Hudson, Kevin; Hancox, Urs J.; Trigwell, Cath; McEwen, Robert; Polanska, Urszula M.; Nikolaou, Myria; Gutierrez, Pablo Morentin; Avivar-Valderas, Alvaro; Delpuech, Oona; Dudley, Phillippa; Hanson, Lyndsey; Ellston, Rebecca; Jones, Alys; Cumberbatch, Marie; Cosulich, Sabina C.; Ward, Lara; Cruzalegui, Francisco; Green, Stephen 分享 收藏
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Combining AZD8186, an inhibitor of PI3Kbeta, with inhibitors of PI3Kalpha and mTORC1/2 gives comprehensive pathway suppression and enhanced antitumor activity in PTEN null tumors Hancox, Urs; Polanska, Urszula; Lynch, James T.; Lenagnan, Carol; Trigwell, Cath; Depuelch, Oona; Dudley, Phillippa; Maynard, Juliana; Ward, Lara; Hudson, Kevin; Curwen, Jon; Cruzalegui, Francisco; Green, Stephen; Teresa, Klinowska; Barry, Simon T. 分享 收藏
Discovery of AZD8835, a potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of PIK3CA-dependent cancers Barlaam, Bernard; Cosulich, Sabina; Delouvrie, Benedicte; Fitzek, Martina; Germain, Herve; Green, Stephen; Harris, Craig S.; Hudson, Kevin; Lambert-van der Brempt, Christine; Lamorlette, Maryannick; Antoine, Le Griffon; Morgentin, Remy; Ouvry, Gilles; Page, Ken; Pasquet, Georges; Ruston, Linette; Saleh, Twana; Vautier, Michel; Ward, Lara 分享 收藏
High dose intermittent scheduling of AZD8835, a novel potent and selective inhibitor of PI3Kα and PI3Kδ, identifies potential treatment strategies for PIK3CA-dependent cancers Hudson, Kevin; Hancox, Urs; Trigwell, Cath; Dudley, Phillippa; Hanson, Lyndsey; McEwen, Robert; Jones, Alys; Cumberbatch, Marie; Polanska, Urszula; Ellston, Rebecca; Delpuech, Oona; Gutierrez, Pablo Morentin; Ward, Lara; Cruzalegui, Francisco; Green, Stephen 分享 收藏
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Comprehensive PI3K pathway inhibition through combination of the PI3Kβ/δ inhibitor AZD8186 and the mTORC1/2 inhibitor AZD2014 drives tumor regression in vivo Hancox, Urs; Polanska, Urszula; Hanson, Lyndsay; Ellston, Rebecca; Maynard, Julia; Kraus, Manfred; Curwen, Jon; Klinowska, Teresa; Ward, Lara; Cruzalegui, Francisco; Green, Stephen; Symeonides, Stefan; Cronin, Kathryn; Barry, Simon 分享 收藏
Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel Hancox, Urs; Cosulich, Sabina; Hanson, Lyndsey; Trigwell, Cath; Lenaghan, Carol; Ellston, Rebecca; Dry, Hannah; Crafter, Claire; Barlaam, Bernard; Fitzek, Martina; Smith, Paul D.; Ogilvie, Donald; D'Cruz, Celina; Castriotta, Lillian; Wedge, Stephen R.; Ward, Lara; Powell, Steve; Lawson, Mandy; Davies, Barry R.; Harrington, Elizabeth A.; Foster, Emily; Cumberbatch, Marie; Green, Stephen; Barry, Simon T. 分享 收藏
Discovery of (R)-8-(1-(3,5-Difluorophenylamino)ethyl)-N,N-dimethy12-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and P13Kδ for the Treatment of PTEN-Deficient Cancers Barlaam, Bernard; Cosulich, Sabina; Degorce, Sebastien; Fitzek, Martina; Green, Stephen; Hancox, Urs; Lambert-van der Brempt, Christine; Lohmann, Jean-Jacques; Maudet, Mickael; Morgentin, Remy; Pasquet, Marie-Jeanne; Peru, Aurelien; Ple, Patrick; Saleh, Twana; Vautier, Michel; Walker, Mike; Ward, Lara; Warin, Nicolas 分享 收藏
The PI3Kbeta/delta inhibitor AZD8186 combines with the dual mTORC1/2 inhibitor AZD2014 to give comprehensive PI3K pathway inhibition and drive tumour regression in vivo Simon, B.; Hancox, U.; Polanska, U.; Hanson, L.; Dudley, P.; Ellston, R.; Maynard, J.; Kraus, M.; Curwen, J.; Klinowska, T.; Ward, L.; Cruzalegui, F.; Symeonides, S.; Cronin, K. 分享 收藏
8-(1-Anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxamides as PI3Kbeta/delta inhibitors: structure activity relationships and identification of AZD8186, a clinical candidate for the treatment of PTEN deficient tumours Barlaam, B.; Cosulich, S.; Degorce, S.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J. J.; Maudet, M.; Morgentin, R.; Pasquest, M. J.; Peru, A.; Ple, P.; Saleh, T.; Vautier, M.; Walker, M.; Ward, L.; Warin, N. 分享 收藏
The Pi3Kβ/δ inhibitor AZD8186 has potential to treat tumours in combination with key signalling pathway inhibitors Barry, Simon T.; Cronin, Kathryn; Cumberbatch, Marie; Ellston, Rebecca; Foster, Emily; Hancox, Urs; Hanson, Lyndsey; Harrington, Liz; Lenaghan, Carol; Symeonides, Stefan; Trigwell, Cath; Ward, Lara 分享 收藏
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