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收藏Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma
Visser, Michael; Papillon, Julien P. N.; Luzzio, Michael; Lamarche, Matthew J.; Fan, Jianmei; Michael, Walter; Wang, David; Zhang, Alan; Straub, Christopher; Mathieu, Simon; Kato, Mitsunori; Palermo, Mark; Chen, Christine; Ramsey, Timothy; Joud, Carol; Barrett, Rosemary; Vattay, Anthony; Guo, Ribo; Bric, Anka; Chung, Franklin; Liang, Guiqing; Romanowski, Michael J.; Lam, Joni; Thohan, Sanjeev; Atassi, Faraj; Wylie, Andrew; Cooke, Vesselina G. 分享 收藏 Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of CancerLaMarche, Matthew J.; Acker, Michael; Argintaru, Andreea; Bauer, Daniel; Boisclair, Julie; Chan, Homan; Chen, Christine Hiu-Tung; Chen, Ying-Nan; Chen, Zhouliang; Deng, Zhan; Dore, Michael; Dunstan, David; Fan, Jianmei; Fekkes, Peter; Firestone, Brant; Fodor, Michelle; Garcia-Fortanet, Jorge; Fortin, Pascal D.; Fridrich, Cary; Giraldes, John; Glick, Meir; Grunenfelder, Denise; Hao, Huia-Xiang; Hentemann, Martin; Ho, Samuel; Jouk, Andriana; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; Koenig, Robert; LaBonte, Laura R.; Larrow, Jay; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Mathieu, Simon; Meyer, Matthew J.; Mohseni, Morvarid; Ntaganda, Rukundo; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Reilly, John; Sarver, Patrick; Sellers, William R.; Sendzik, Martin; Shultz, Michael D.; Slisz, Joanna; Slocum, Kelly; Smith, Troy; Spence, Stanley; Stams, Travis; Straub, Christopher; Tamez, Victoriano, Jr.; Toure, Bakary-Barry; Towler, Christopher; Wang, Ping; Wang, Hongyun; Williams, Sarah L.; Yang, Fan; Yu, Bing; Zhang, Ji-Hu; Zhu, Suzanne 分享 收藏 Addition and Subtraction: Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase InhibitorsChen, Xin; Giraldes, John; Sprague, Elizabeth R.; Shakya, Subarna; Chen, Zhuoliang; Wang, Yaping; Joud, Carol; Mathieu, Simon; Chen, Christine Hiu-Tung; Straub, Christopher; Duca, Jose; Hurov, Kristen; Yuan, Yanqiu; Shao, Wenlin; Toure, B. Barry 分享 收藏 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology InsightToure, B. Barry; Giraldes, John; Smith, Troy; Sprague, Elizabeth R.; Wang, Yaping; Mathieu, Simon; Chen, Zhuoliang; Mishina, Yuji; Feng, Yun; Yan-Neale, Yan; Shakya, Subarna; Chen, Dongshu; Meyer, Matthew; Puleo, David; Brazell, J. Tres; Straub, Christopher; Sage, David; Wright, Kirk; Yuan, Yanqiu; Chen, Xin; Duca, Jose; Kim, Sean; Tian, Li; Martin, Eric; Hurov, Kristen; Shao, Wenlin 分享 收藏 IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolismGrassian, Alexandra R.; Parker, Seth; Davidson, Shawn; Divakaruni, Ajit; Green, Courtney; Zhang, Xiamei; Slocum, Kelly; Pu, Minying; Lin, Fallon; Vickers, Chad; Joud-Caldwell, Carol; Chung, Franklin; Yin, Hong; Handly, Erika; Straub, Christopher; Growney, Joseph D.; Heiden, Matt Vander; Murphy, Anne; Pagliarini, Raymond; Metallo, Christian 分享 收藏 IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial MetabolismGrassian, Alexandra R.; Parker, Seth J.; Davidson, Shawn M.; Divakaruni, Ajit S.; Green, Courtney R.; Zhang, Xiamei; Slocum, Kelly L.; Pu, Minying; Lin, Fallon; Vickers, Chad; Joud-Caldwell, Carol; Chung, Franklin; Yin, Hong; Handly, Erika D.; Straub, Christopher; Growney, Joseph D.; Vander Heiden, Matthew G.; Murphy, Anne N.; Pagliarini, Raymond; Metallo, Christian M. 分享 收藏 分享 收藏 Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation.Grassiani, Alexandra R.; Parker, Seth; Davidson, Shawn; Green, Courtney; Lin, Fallon; Joud-Caldwelli, Carol; Yin, Hong; Chung, Franklin; Straub, Christopher; Vander Heiden, Matthew; Pagliarini, Raymond; Metallo, Christian 分享 收藏 分享 收藏 Therapeutic targeting of inhibitor of apoptosis proteinsZawel, Leigh S.; Straub, Christopher; Firestone, Brant; Sullivan, John; Levine, Kymberly; Porter, Dale; Conway, Colleen; Yang, Guizhi; Gao, Hui; He, Dan; Slisz, Joanna; Morrissey, Michael; Monahan, John; Mosher, Rebecca; Stegmeier, Frank; He, Feng; Pham, Ly; Yang, Fan; Chen, Julian; Ramsey, Tim; Yao, Megan; Fawell, Stephen 分享 收藏 Correlation between TNFα and LCL161 anti-tumor activity in patient derived xenograft models of human cancerFirestone, Brant; Conway, Colleen; Yang, Guizhi; Gao, Hui; Porter, Dale; Slisz, Joanna; He, Dan; Mosher, Rebecca; Monahan, John; Straub, Christopher; Morrissey, Michael; Yao, Yung-mae; Zawel, Leigh 分享 收藏 A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signalingGaither, Alex; Porter, Dale; Yao, Yao; Borawski, Jason; Yang, Guang; Donovan, Jerry; Sage, David; Slisz, Joanna; Tran, Mary; Straub, Christopher; Ramsey, Tim; Iourgenko, Vadim; Huang, Alan; Chen, Yan; Schlegel, Robert; Labow, Mark; Fawell, Stephen; Sellers, William R.; Zawel, Leigh 分享 收藏 A facile preparation of an octahydropyrrolo[2,3-c]pyridine enantiomerShieh, Wen-Chung; Chen, Guang-Pei; Xue, Song; McKenna, Joseph; Jiang, Xinglong; Prasad, Kapa; Repic, Oljan; Straub, Christopher; Sharma, Sushil K. 分享 收藏 分享 收藏 
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