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Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Siegel, Dustin S.; Hui, Hon C.; Pitts, Jared; Vermillion, Meghan S.; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O.; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C.; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y.; Perry, Jason K.; Perron, Michel; Bilello, John P.; Kuehl, Philip J.; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L. 分享 收藏
Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV Mackman, Richard L.; Hui, Hon C.; Perron, Michel; Murakami, Eisuke; Palmiotti, Christopher; Lee, Gary; Stray, Kirsten; Zhang, Lijun; Goyal, Bindu; Chun, Kwon; Byun, Daniel; Siegel, Dustin; Simonovich, Scott; Du Pont, Venice; Pitts, Jared; Babusis, Darius; Vijjapurapu, Arya; Lu, Xianghan; Kim, Cynthia; Zhao, Xiaofeng; Chan, Julie; Ma, Bin; Lye, Diane; Vandersteen, Adelle; Wortman, Sarah; Barrett, Kimberly T.; Toteva, Maria; Jordan, Robert; Subramanian, Raju; Bilello, John P.; Cihlar, Tomas 分享 收藏
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer Gross, Matt I.; Demo, Susan D.; Dennison, Jennifer B.; Chen, Lijing; Chernov-Rogan, Tania; Goyal, Bindu; Janes, Julie R.; Laidig, Guy J.; Lewis, Evan R.; Li, Jim; MacKinnon, Andrew L.; Parlati, Francesco; Rodriguez, Mirna L. M.; Shwonek, Peter J.; Sjogren, Eric B.; Stanton, Timothy F.; Wang, Taotao; Yang, Jinfu; Zhao, Frances; Bennett, Mark K. 分享 收藏
Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition Safina, Brian S.; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M.; Chan, Bryan K.; Chen, Yung-Hsiang; Cartwright, Matthew W.; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J.; Goldsmith, Paul; Goldstein, David M.; Goyal, Bindu; Hancox, Timothy; Handa, Raj K.; Lyer, Pravin S.; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R.; Krintel, Sussie L.; Li, Jun; Lesnick, John; Lucas, Matthew C.; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J.; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S.; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A.; Seward, Eileen M.; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K.; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P. 分享 收藏
Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases Gavai, Ashvinikumar V.; Fink, Brian E.; Fairfax, David J.; Martin, Gregory S.; Rossiter, Lana M.; Holst, Christian L.; Kim, Soong-Hoon; Leavitt, Kenneth J.; Mastalerz, Harold; Han, Wen-Ching; Norris, Derek; Goyal, Bindu; Swaminathan, Shankar; Patel, Bharat; Mathur, Arvind; Vyas, Dolatrai M.; Tokarski, John S.; Yu, Chiang; Oppenheimer, Simone; Zhang, Hongjian; Marathe, Punit; Fargnoli, Joseph; Lee, Francis Y.; Wong, Tai W.; Vite, Gregory D. 分享 收藏
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