Suvi T. M. Orr

Pfizer

H指数:16

被引数:1,021

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Discovery of a potent and orally bioavailable reversible TEAD inhibitor (R)-3-(5-(1-methyl-3-((4-(trifluoromethyl)phenyl) amino)-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)-3-vinylpyrrolidin-2-one

发现一种强效且口服生物利用度高的可逆TEAD抑制剂（R）-3-（5-（1-甲基-3-（（4-（三氟甲基）苯基）氨基）-1H-吡唑-4-基）-1,3,4-噁二唑-2-基）-3-乙烯基吡咯烷-2-酮

Results in Chemistry

IF4.2

2026-05-010

OAAI

Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-12-010

PRE

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

CDK4选择性抑制提高了临床前抗肿瘤疗效和安全性

CANCER CELL

IF44.5

2025-03-011

OAAI

Palmer, Cynthia L.; Boras, Britton; Pascual, Bernadette; Li, Na; Li, Danan; Garza, Scott; Huser, Nanni; Yuan, Jing Tang; Cianfrogna, Julie A.; Sung, Tae; Mcmillan, Elizabeth; Wei, Na; Carmody, Jason; Kang, Aubrey Nayeon; Darensburg, Seth; Dodd, Taran; Oakley, James, V; Solowiej, James; Nguyen, Lisa; Orr, Suvi T. M.; Chen, Ping; Johnson, Eric; Yu, Xiu; Diehl, Wade C.; Gallego, Gary M.; Jalaie, Mehran; Ferre, Rose Ann; Cho-Schultz, Sujin; Shen, Hong; Deal, Judith G.; Zhang, Qin; Baffi, Timothy R.; Xu, Meirong; Roh, Whijae; Lapira-Miller, Jennifer; Goudeau, Jerome; Yu, Yanke; Gupta, Rajat; Kim, Kimberly; Dann, Stephen G.; Kan, Zhengyan; Kath, John C.; Nair, Sajiv K.; Miller, Nichol; Murray, Brion W.; Nager, Andrew R.; Quinlan, Casey; Petroski, Matthew D.; Zhang, Cathy; Sacaan, Aida; Vanarsdale, Todd; Anders, Lars

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-12-2426

PREAI

Cheng, Hengmiao; Orr, Suvi T. M.; Bailey, Simon; Brooun, Alexei; Chen, Ping; Deal, Judith G.; Deng, Yali L.; Edwards, Martin P.; Gallego, Gary M.; Grodsky, Neil; Huang, Buwen; Jalaie, Mehran; Kaiser, Stephen; Kania, Robert S.; Kephart, Susan E.; Lafontaine, Jennifer; Ornelas, Martha A.; Pairish, Mason; Planken, Simon; Shen, Hong; Sutton, Scott; Zehnder, Luke; Almaden, Chau D.; Bagrodia, Shubha; Falk, Matthew D.; Gukasyan, Hovhannes J.; Ho, Caroline; Kang, Xiaolin; Kosa, Rachel E.; Liu, Ling; Spilker, Mary E.; Timofeevski, Sergei; Visswanathan, Ravi; Wang, Zhenxiong; Meng, Fanxiu; Ren, Shijian; Shao, Li; Xu, Feng; Kath, John C.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-2984

PREAI

Planken, Simon; Behenna, Douglas C.; Nair, Sajiv K.; Johnson, Theodore O.; Nagata, Asako; Almaden, Chau; Bailey, Simon; Ballard, T. Eric; Bernier, Louise; Cheng, Hengmiao; Cho-Schultz, Sujin; Dalvie, Deepak; Deal, Judith G.; Dinh, Dac M.; Edwards, Martin P.; Ferre, Rose Ann; Gajiwala, Ketan S.; Hemkens, Michelle; Kania, Robert S.; Kath, John C.; Matthews, Jean; Murray, Brion W.; Niessen, Sherry; Orr, Suvi T. M.; Pairish, Mason; Sach, Neal W.; Shen, Hong; Shi, Manli; Solowiej, James; Khanh Tran; Tseng, Elaine; Vicini, Paolo; Wang, Yuli; Weinrich, Scott L.; Zhou, Ru; Zientek, Michael; Liu, Longqing; Luo, Yiqin; Xin, Shuibo; Zhang, Chengyi; Lafontaine, Jennifer

Discovery of 1-{(3R,4R)-3[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-01-2896

PREAI

Cheng, Hengmiao; Nair, Sajiv K.; Murray, Brion W.; Almaden, Chau; Bailey, Simon; Baxi, Sangita; Behenna, Doug; Cho-Schultz, Sujin; Dalvie, Deepak; Dinh, Dac M.; Edwards, Martin P.; Feng, Jun Li; Ferre, Rose Ann; Gajiwala, Ketan S.; Hemkens, Michelle D.; Jackson-Fisher, Amy; Jalaie, Mehran; Johnson, Ted O.; Kania, Robert S.; Kephart, Susan; Lafontaine, Jennifer; Lunney, Beth; Liu, Kevin K-C.; Liu, Zhengyu; Matthews, Jean; Nagata, Asako; Niessen, Sherry; Ornelas, Martha A.; Orr, Suvi T. M.; Pairish, Mason; Planken, Simon; Ren, Shijian; Richter, Daniel; Ryan, Kevin; Sach, Neal; Shen, Hong; Smeal, Tod; Solowiej, Jim; Sutton, Scott; Tran, Khanh; Tseng, Elaine; Vemier, William; Walls, Marlena; Wang, Shuiwang; Weinrich, Scott L.; Xin, Shuibo; Xu, Haiwei; Yin, Min-Jean; Zientek, Michael; Zhou, Ru; Kath, John C.

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-10-2854

PREAI

Ruggeri, Roger B.; Buckbinder, Leonard; Bagley, Scott W.; Carpino, Philip A.; Conn, Edward L.; Dowling, Matthew S.; Fernando, Dilinie P.; Jiao, Wenhua; Kung, Daniel W.; Orr, Suvi T. M.; Qi, Yingmei; Rocke, Benjamin N.; Smith, Aaron; Warmus, Joseph S.; Zhang, Yan; Bowles, Daniel; Widlicka, Daniel W.; Eng, Heather; Ryder, Tim; Sharma, Raman; Wolford, Angela; Okerberg, Carlin; Walters, Karen; Maurer, Tristan S.; Zhang, Yanwei; Bonin, Paul D.; Spath, Samantha N.; Xing, Gang; Hepworth, David; Kay Ahn; Kalgutkar, Amit S.

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2015-10-0638

OAAI

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-09-1568

PREAI

Futatsugi, Kentaro; Kung, Daniel W.; Orr, Suvi T. M.; Cabral, Shawn; Hepworth, David; Aspnes, Gary; Bader, Scott; Bian, Jianwei; Boehm, Markus; Carpino, Philip A.; Coffey, Steven B.; Dowling, Matthew S.; Herr, Michael; Jiao, Wenhua; Lavergne, Sophie Y.; Li, Qifang; Clark, Ronald W.; Erion, Derek M.; Kou, Kou; Lee, Kyuha; Pabst, Brandon A.; Perez, Sylvie M.; Purkal, Julie; Jorgensen, Csilla C.; Goosen, Theunis C.; Gosset, James R.; Niosi, Mark; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Ahn, Kay; Goodwin, Bryan

Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-12-1916

OAAI

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-02-2463

OAAI

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

鉴定四氢吡啶并 [4，3-d] 嘧啶酰胺作为一类新的口服生物可利用的TGR5激动剂