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Data- and knowledge-derived functional landscape of human solute carriers 基于数据和知识导出的溶质载体的人类功能景观 Goldmann, Ulrich; Wiedmer, Tabea; Garofoli, Andrea; Sedlyarov, Vitaly; Bichler, Manuel; Haladik, Ben; Wolf, Gernot; Christodoulaki, Eirini; Ingles-Prieto, Alvaro; Ferrada, Evandro; Frommelt, Fabian; Teoh, Shao Thing; Leippe, Philipp; Onea, Gabriel; Pfeifer, Martin; Kohlbrenner, Mariah; Chang, Lena; Selzer, Paul; Reinhardt, Juergen; Digles, Daniela; Ecker, Gerhard F.; Osthushenrich, Tanja; MacNamara, Aidan; Malarstig, Anders; Hepworth, David 分享 收藏
Cyclic Peptide C5aR1 Antagonist Design Using Solution Conformational Analysis Derived from Residual Dipolar Couplings Farley, Kathleen A.; Che, Ye; Lira, Ricardo; Jones, Peter; Papaioannou, Nikolaos; Hayward, Matthew; Flanagan, Mark E.; Langille, Jonathan; Liang, Sidney; Pierce, Betsy S.; Ciszewski, Gregory; Bonin, Paul; Vincent, Fabien; Ramsey, Simeon; Hepworth, David 分享 收藏
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Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1 一系列嘧啶甲酰胺类Vanin-1抑制剂的发现 Casimiro-Garcia, Agustin; Allais, Christophe; Brennan, Agnes; Choi, Chulho; Dower, Gabriela; Farley, Kathleen A.; Fleming, Margaret; Flick, Andrew; Frisbie, Richard K.; Hall, Justin; Hepworth, David; Jones, Hannah; Knafels, John D.; Kortum, Steve; Lovering, Frank E.; Mathias, John P.; Mohan, Sashi; Morgan, Paul M.; Parng, Chuenlei; Parris, Kevin; Pullen, Nick; Schlerman, Franklin; Stansfield, John; Strohbach, Joseph W.; Vajdos, Felix F.; Vincent, Fabien; Wang, Hong; Wang, Xiaolun; Webster, Robert; Wright, Stephen W. 分享 收藏
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Nanofibers Produced from Agro-Industrial Plant Waste Using Entirely Enzymatic Pretreatments Holland, Claire; Perzon, Alixander; Cassland, Pierre R. C.; Jensen, John P.; Langebeck, Birger; Sorensen, Ole Bandsholm; Whale, Eric; Hepworth, David; Plaice-Inglis, Robyn; Moestrup, Ojvind; Ulvskov, Peter; Jorgensen, Bodil 分享 收藏
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors Lovering, Frank; Morgan, Paul; Allais, Christophe; Aulabaugh, Ann; Brodfuehrer, Joanne; Chang, Jeanne; Coe, Jotham; Ding, WeiDong; Dowty, Heather; Fleming, Margaret; Frisbie, Richard; Guzova, Julia; Hepworth, David; Jasti, Jayasankar; Kortum, Steve; Kurumbail, Ravi; Mohan, Shashi; Papaioannou, Nikolaos; Strohbach, Joseph W.; Vincent, Fabien; Lee, Katherine; Zapf, Christoph W. 分享 收藏
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment -Based Drug Design Lee, Katherine L.; Ambler, Catherine M.; Anderson, David R.; Boscoe, Brian P.; Bree, Andrea G.; Brodfuehrer, Joanne I.; Chang, Jeanne S.; Choi, Chulho; Chung, Seungwon; Curran, Kevin J.; Day, Jacqueline E.; Dehnhardt, Christoph M.; Dower, Ken; Drozda, Susan E.; Frisbie, Richard K.; Gavrin, Lori K.; Goldberg, Joel A.; Han, Seungil; Hegen, Martin; Hepworth, David; Hope, Heidi R.; Kamtekar, Satwik; Kilty, Iain C.; Lee, Arthur; Ling, Lih-Ling; Lovering, Frank E.; Lowe, Michael D.; Mathias, John P.; Morgan, Heidi M.; Murphy, Elizabeth A.; Papaioannou, Nikolaos; Patny, Akshay; Pierce, Betsy S.; Rao, Vikram R.; Saiah, Eddine; Samardjiev, Ivan J.; Samas, Brian M.; Shen, Marina W. H.; Shin, Julia H.; Soutter, Holly H.; Strohbach, Joseph W.; Symanowicz, Peter T.; Thomason, Jennifer R.; Trzupek, John D.; Vargas, Richard; Vincent, Fabien; Yan, Jiangli; Zapf, Christoph W.; Wright, Stephen W. 分享 收藏
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation Petersen, Donna N.; Hawkins, Julie; Ruangsiriluk, Wanida; Stevens, Kimberly A.; Maguire, Bruce A.; O'Connell, Thomas N.; Rocke, Benjamin N.; Boehm, Markus; Ruggeri, Roger B.; Rolph, Tim; Hepworth, David; Loria, Paula M.; Carpino, Philip A. 分享 收藏
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation Primiano, Michael J.; Lefker, Bruce A.; Bowman, Michael R.; Bree, Andrea G.; Hubeau, Cedric; Bonin, Paul D.; Mangan, Matthew; Dower, Ken; Monks, Brian G.; Cushing, Leah; Wang, Stephen; Guzova, Julia; Jiao, Aiping; Lin, Lih-Ling; Latz, Eicke; Hepworth, David; Hall, J. Perry 分享 收藏
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy 发现和临床前表征6-氯-5-[4-(1-羟基环丁基) 苯基]-1h-吲哚-3-羧酸 (PF-06409577)，一磷酸腺苷激活的蛋白激酶 (AMPK) 的直接激活剂，用于糖尿病肾病的潜在治疗 Cameron, Kimberly O.; Kung, Daniel W.; Kalgutkar, Amit S.; Kurumbail, Ravi G.; Miller, Russell; Salatto, Christopher T.; Ward, Jessica; Withka, Jane M.; Bhattacharya, Samit K.; Boehm, Markus; Borzilleri, Kris A.; Brown, Janice A.; Calabrese, Matthew; Caspers, Nicole L.; Cokorinos, Emily; Conn, Edward L.; Dowling, Matthew S.; Edmonds, David J.; Eng, Heather; Fernando, Dilinie P.; Frisbie, Richard; Hepworth, David; Landro, James; Mao, Yuxia; Rajamohan, Francis; Reyes, Allan R.; Rose, Colin R.; Ryder, Tim; Shavnya, Andre; Smith, Aaron C.; Tu, Meihua; Wolford, Angela C.; Xiao, Jun 分享 收藏
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) Huard, Kim; Brown, Janice; Jones, Jessica C.; Cabral, Shawn; Futatsugi, Kentaro; Gorgoglione, Matthew; Lanba, Adhiraj; Vera, Nicholas B.; Zhu, Yimin; Yan, Qingyun; Zhou, Yingjiang; Vernochet, Cecile; Riccardi, Keith; Wolford, Angela; Pirman, David; Niosi, Mark; Aspnes, Gary; Herr, Michael; Genung, Nathan E.; Magee, Thomas V.; Uccello, Daniel P.; Loria, Paula; Di, Li; Gosset, James R.; Hepworth, David; Rolph, Timothy; Pfefferkorn, Jeffrey A.; Erion, Derek M. 分享 收藏
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases Ruggeri, Roger B.; Buckbinder, Leonard; Bagley, Scott W.; Carpino, Philip A.; Conn, Edward L.; Dowling, Matthew S.; Fernando, Dilinie P.; Jiao, Wenhua; Kung, Daniel W.; Orr, Suvi T. M.; Qi, Yingmei; Rocke, Benjamin N.; Smith, Aaron; Warmus, Joseph S.; Zhang, Yan; Bowles, Daniel; Widlicka, Daniel W.; Eng, Heather; Ryder, Tim; Sharma, Raman; Wolford, Angela; Okerberg, Carlin; Walters, Karen; Maurer, Tristan S.; Zhang, Yanwei; Bonin, Paul D.; Spath, Samantha N.; Xing, Gang; Hepworth, David; Kay Ahn; Kalgutkar, Amit S. 分享 收藏
The promise and peril of chemical probes (vol 11, pg 536, 2015) Arrowsmith, Cheryl H.; Audia, James E.; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E.; Buser-Doepner, Carolyn; Campbell, Robert M.; Carter, Adrian J.; Cohen, Philip; Copeland, Robert A.; Cravatt, Ben; Dahlin, Jayme L.; Dhanak, Dashyant; Edwards, Aled M.; Frederiksen, Mathias; Frye, Stephen V.; Gray, Nathanael; Grimshaw, Charles E.; Hepworth, David; Howe, Trevor; Huber, Kilian V. M.; Jin, Jian; Knapp, Stefan; Kotz, Joanne D.; Kruger, Ryan G.; Lowe, Derek; Mader, Mary M.; Marsden, Brian; Mueller-Fahrnow, Anke; Mueller, Susanne; O'Hagan, Ronan C.; Overington, John P.; Owen, Dafydd R.; Rosenberg, Saul H.; Ross, Ruth; Roth, Bryan; Schapira, Matthieu; Schreiber, Stuart L.; Shoichet, Brian; Sundstroem, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A.; Willson, Timothy M.; Workman, Paul; Young, Robert N.; Zuercher, William J. 分享 收藏
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment Ammirati, Mark; Bagley, Scott W.; Bhattacharya, Samit K.; Buckbinder, Leonard; Carlo, Anthony A.; Conrad, Rebecca; Cortes, Christian; Dow, Robert L.; Dowling, Matthew S.; El-Kattan, Ayman; Ford, Kristen; Guimaraes, Cristiano R. W.; Hepworth, David; Jiao, Wenhua; LaPerle, Jennifer; Liu, Shenping; Londregan, Allyn; Loria, Paula M.; Mathiowetz, Alan M.; Munchhoft, Michael; Orr, Suvi T. M.; Petersen, Donna N.; Price, David A.; Skoura, Athanasia; Smith, Aaron C.; Wang, Jian 分享 收藏
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) Futatsugi, Kentaro; Kung, Daniel W.; Orr, Suvi T. M.; Cabral, Shawn; Hepworth, David; Aspnes, Gary; Bader, Scott; Bian, Jianwei; Boehm, Markus; Carpino, Philip A.; Coffey, Steven B.; Dowling, Matthew S.; Herr, Michael; Jiao, Wenhua; Lavergne, Sophie Y.; Li, Qifang; Clark, Ronald W.; Erion, Derek M.; Kou, Kou; Lee, Kyuha; Pabst, Brandon A.; Perez, Sylvie M.; Purkal, Julie; Jorgensen, Csilla C.; Goosen, Theunis C.; Gosset, James R.; Niosi, Mark; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Ahn, Kay; Goodwin, Bryan 分享 收藏
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